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Diagnostic Utility of Caveolin-1 and MOC-31 in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma.

Lee HW, Lee EH, Lee CH, Chang HK, Rha SH - Korean J Urol (2011)

Bottom Line: Renal tumors consist of heterogeneous groups that frequently show complex and overlapping morphology, thus making it difficult to make a correct diagnosis.These should be distinguished by differences in their behavior and clinical outcome.In addition, clear cell RCC was also significantly different from oncocytoma in the expression of caveolin-1 (p<0.001) and was significantly different from chromophobe RCC in the expression of MOC-31 (p<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

ABSTRACT

Purpose: Renal tumors consist of heterogeneous groups that frequently show complex and overlapping morphology, thus making it difficult to make a correct diagnosis. One of the most problematic differential diagnoses is to distinguish chromophobe renal cell carcinoma (RCC) from oncocytoma. These should be distinguished by differences in their behavior and clinical outcome. Our study was performed to identify whether caveolin-1 and MOC-31 are useful immunohistochemical markers for differentiating chromophobe RCC from oncocytoma.

Materials and methods: We selected 23 chromophobe RCCs, 8 oncocytomas, and 25 clear cell RCCs and performed immunohistochemical staining for caveolin-1 and MOC-31.

Results: Caveolin-1 was positive in 20 (87%) of 23 chromophobe RCCs, 0 of 8 oncocytomas, and 21 (84%) of 25 clear cell RCCs. MOC-31 was positive in 22 (96%) of 23 chromophobe RCCs, 2 (25%) of 8 oncocytomas, and 14 (56%) of 25 clear cell RCCs. There was a statistically significant difference in the expression of caveolin-1 and MOC-31 between chromophobe RCC and oncocytoma (p<0.001). In addition, clear cell RCC was also significantly different from oncocytoma in the expression of caveolin-1 (p<0.001) and was significantly different from chromophobe RCC in the expression of MOC-31 (p<0.001).

Conclusions: Caveolin-1 and MOC-31 can be useful markers in the differential diagnosis of chromophobe RCC, oncocytoma, and clear cell RCC.

No MeSH data available.


Related in: MedlinePlus

Expression of caveolin-1 in clear cell renal cell carcinoma. (A) Clear cell type shows membranous staining of caveolin-1. (B) Granular cell type shows diffuse cytoplasmic staining with membranous condensation similar to chromophobe renal cell carcinoma.
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Figure 3: Expression of caveolin-1 in clear cell renal cell carcinoma. (A) Clear cell type shows membranous staining of caveolin-1. (B) Granular cell type shows diffuse cytoplasmic staining with membranous condensation similar to chromophobe renal cell carcinoma.

Mentions: Clear cell RCCs were diffuse positive in 19, focal positive in 2, and negative in 4. The total number of positive cases was 21 (84%) of 25 clear cell RCCs. All 10 cases of the clear cell type were diffuse positive, whereas 9 (60%) of 15 cases of the granular cell type were diffuse positive. There was a slight difference in the pattern of immunohistochemical staining between the clear and granular cell types. All cases of the clear cell type showed dominantly membranous staining without cytoplasmic staining (Fig. 3A), whereas most cases of the granular cell type exhibited a similar staining pattern to that of chromophobe RCC, namely, a diffusely cytoplasmic and granular pattern with focal membranous condensation (Fig. 3B).


Diagnostic Utility of Caveolin-1 and MOC-31 in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma.

Lee HW, Lee EH, Lee CH, Chang HK, Rha SH - Korean J Urol (2011)

Expression of caveolin-1 in clear cell renal cell carcinoma. (A) Clear cell type shows membranous staining of caveolin-1. (B) Granular cell type shows diffuse cytoplasmic staining with membranous condensation similar to chromophobe renal cell carcinoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3045726&req=5

Figure 3: Expression of caveolin-1 in clear cell renal cell carcinoma. (A) Clear cell type shows membranous staining of caveolin-1. (B) Granular cell type shows diffuse cytoplasmic staining with membranous condensation similar to chromophobe renal cell carcinoma.
Mentions: Clear cell RCCs were diffuse positive in 19, focal positive in 2, and negative in 4. The total number of positive cases was 21 (84%) of 25 clear cell RCCs. All 10 cases of the clear cell type were diffuse positive, whereas 9 (60%) of 15 cases of the granular cell type were diffuse positive. There was a slight difference in the pattern of immunohistochemical staining between the clear and granular cell types. All cases of the clear cell type showed dominantly membranous staining without cytoplasmic staining (Fig. 3A), whereas most cases of the granular cell type exhibited a similar staining pattern to that of chromophobe RCC, namely, a diffusely cytoplasmic and granular pattern with focal membranous condensation (Fig. 3B).

Bottom Line: Renal tumors consist of heterogeneous groups that frequently show complex and overlapping morphology, thus making it difficult to make a correct diagnosis.These should be distinguished by differences in their behavior and clinical outcome.In addition, clear cell RCC was also significantly different from oncocytoma in the expression of caveolin-1 (p<0.001) and was significantly different from chromophobe RCC in the expression of MOC-31 (p<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

ABSTRACT

Purpose: Renal tumors consist of heterogeneous groups that frequently show complex and overlapping morphology, thus making it difficult to make a correct diagnosis. One of the most problematic differential diagnoses is to distinguish chromophobe renal cell carcinoma (RCC) from oncocytoma. These should be distinguished by differences in their behavior and clinical outcome. Our study was performed to identify whether caveolin-1 and MOC-31 are useful immunohistochemical markers for differentiating chromophobe RCC from oncocytoma.

Materials and methods: We selected 23 chromophobe RCCs, 8 oncocytomas, and 25 clear cell RCCs and performed immunohistochemical staining for caveolin-1 and MOC-31.

Results: Caveolin-1 was positive in 20 (87%) of 23 chromophobe RCCs, 0 of 8 oncocytomas, and 21 (84%) of 25 clear cell RCCs. MOC-31 was positive in 22 (96%) of 23 chromophobe RCCs, 2 (25%) of 8 oncocytomas, and 14 (56%) of 25 clear cell RCCs. There was a statistically significant difference in the expression of caveolin-1 and MOC-31 between chromophobe RCC and oncocytoma (p<0.001). In addition, clear cell RCC was also significantly different from oncocytoma in the expression of caveolin-1 (p<0.001) and was significantly different from chromophobe RCC in the expression of MOC-31 (p<0.001).

Conclusions: Caveolin-1 and MOC-31 can be useful markers in the differential diagnosis of chromophobe RCC, oncocytoma, and clear cell RCC.

No MeSH data available.


Related in: MedlinePlus