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Diagnostic Utility of Caveolin-1 and MOC-31 in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma.

Lee HW, Lee EH, Lee CH, Chang HK, Rha SH - Korean J Urol (2011)

Bottom Line: Renal tumors consist of heterogeneous groups that frequently show complex and overlapping morphology, thus making it difficult to make a correct diagnosis.These should be distinguished by differences in their behavior and clinical outcome.In addition, clear cell RCC was also significantly different from oncocytoma in the expression of caveolin-1 (p<0.001) and was significantly different from chromophobe RCC in the expression of MOC-31 (p<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

ABSTRACT

Purpose: Renal tumors consist of heterogeneous groups that frequently show complex and overlapping morphology, thus making it difficult to make a correct diagnosis. One of the most problematic differential diagnoses is to distinguish chromophobe renal cell carcinoma (RCC) from oncocytoma. These should be distinguished by differences in their behavior and clinical outcome. Our study was performed to identify whether caveolin-1 and MOC-31 are useful immunohistochemical markers for differentiating chromophobe RCC from oncocytoma.

Materials and methods: We selected 23 chromophobe RCCs, 8 oncocytomas, and 25 clear cell RCCs and performed immunohistochemical staining for caveolin-1 and MOC-31.

Results: Caveolin-1 was positive in 20 (87%) of 23 chromophobe RCCs, 0 of 8 oncocytomas, and 21 (84%) of 25 clear cell RCCs. MOC-31 was positive in 22 (96%) of 23 chromophobe RCCs, 2 (25%) of 8 oncocytomas, and 14 (56%) of 25 clear cell RCCs. There was a statistically significant difference in the expression of caveolin-1 and MOC-31 between chromophobe RCC and oncocytoma (p<0.001). In addition, clear cell RCC was also significantly different from oncocytoma in the expression of caveolin-1 (p<0.001) and was significantly different from chromophobe RCC in the expression of MOC-31 (p<0.001).

Conclusions: Caveolin-1 and MOC-31 can be useful markers in the differential diagnosis of chromophobe RCC, oncocytoma, and clear cell RCC.

No MeSH data available.


Related in: MedlinePlus

Expression of caveolin-1 in chromophobe renal cell carcinoma and oncocytoma. (A) Chromophobe renal cell carcinoma is diffuse, moderate to strong positive for caveolin-1, showing granular and cytoplasmic staining with membranous condensation. (B) Oncocytoma is negative for caveolin-1.
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Figure 2: Expression of caveolin-1 in chromophobe renal cell carcinoma and oncocytoma. (A) Chromophobe renal cell carcinoma is diffuse, moderate to strong positive for caveolin-1, showing granular and cytoplasmic staining with membranous condensation. (B) Oncocytoma is negative for caveolin-1.

Mentions: In chromophobe RCCs, 20 (87%) of 23 cases showed diffuse positivity for caveolin-1. All positive cases showed expression of caveolin-1 in 90% or more of the tumor cells and moderate to strong intensity except for one case that had relatively weak intensity. The pattern of immunohistochemical staining was diffusely cytoplasmic and granular. In most of the cases, the cell membrane was also stained and the staining intensity was stronger in the membrane than in the cytoplasm (Fig. 2A). In the three negative cases, none of the tumor cells expressed caveolin-1.


Diagnostic Utility of Caveolin-1 and MOC-31 in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma.

Lee HW, Lee EH, Lee CH, Chang HK, Rha SH - Korean J Urol (2011)

Expression of caveolin-1 in chromophobe renal cell carcinoma and oncocytoma. (A) Chromophobe renal cell carcinoma is diffuse, moderate to strong positive for caveolin-1, showing granular and cytoplasmic staining with membranous condensation. (B) Oncocytoma is negative for caveolin-1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3045726&req=5

Figure 2: Expression of caveolin-1 in chromophobe renal cell carcinoma and oncocytoma. (A) Chromophobe renal cell carcinoma is diffuse, moderate to strong positive for caveolin-1, showing granular and cytoplasmic staining with membranous condensation. (B) Oncocytoma is negative for caveolin-1.
Mentions: In chromophobe RCCs, 20 (87%) of 23 cases showed diffuse positivity for caveolin-1. All positive cases showed expression of caveolin-1 in 90% or more of the tumor cells and moderate to strong intensity except for one case that had relatively weak intensity. The pattern of immunohistochemical staining was diffusely cytoplasmic and granular. In most of the cases, the cell membrane was also stained and the staining intensity was stronger in the membrane than in the cytoplasm (Fig. 2A). In the three negative cases, none of the tumor cells expressed caveolin-1.

Bottom Line: Renal tumors consist of heterogeneous groups that frequently show complex and overlapping morphology, thus making it difficult to make a correct diagnosis.These should be distinguished by differences in their behavior and clinical outcome.In addition, clear cell RCC was also significantly different from oncocytoma in the expression of caveolin-1 (p<0.001) and was significantly different from chromophobe RCC in the expression of MOC-31 (p<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

ABSTRACT

Purpose: Renal tumors consist of heterogeneous groups that frequently show complex and overlapping morphology, thus making it difficult to make a correct diagnosis. One of the most problematic differential diagnoses is to distinguish chromophobe renal cell carcinoma (RCC) from oncocytoma. These should be distinguished by differences in their behavior and clinical outcome. Our study was performed to identify whether caveolin-1 and MOC-31 are useful immunohistochemical markers for differentiating chromophobe RCC from oncocytoma.

Materials and methods: We selected 23 chromophobe RCCs, 8 oncocytomas, and 25 clear cell RCCs and performed immunohistochemical staining for caveolin-1 and MOC-31.

Results: Caveolin-1 was positive in 20 (87%) of 23 chromophobe RCCs, 0 of 8 oncocytomas, and 21 (84%) of 25 clear cell RCCs. MOC-31 was positive in 22 (96%) of 23 chromophobe RCCs, 2 (25%) of 8 oncocytomas, and 14 (56%) of 25 clear cell RCCs. There was a statistically significant difference in the expression of caveolin-1 and MOC-31 between chromophobe RCC and oncocytoma (p<0.001). In addition, clear cell RCC was also significantly different from oncocytoma in the expression of caveolin-1 (p<0.001) and was significantly different from chromophobe RCC in the expression of MOC-31 (p<0.001).

Conclusions: Caveolin-1 and MOC-31 can be useful markers in the differential diagnosis of chromophobe RCC, oncocytoma, and clear cell RCC.

No MeSH data available.


Related in: MedlinePlus