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Changes in clinicopathological characteristics of renal cell carcinoma in the past 25 years: a single-center experience.

Choi JB, Yoon BI, Kim SJ, Cho HJ, Hong SH, Choi YJ, Kim SW, Hwang TK, Lee JY - Korean J Urol (2011)

Bottom Line: The tumor size at diagnosis gradually decreased and the proportion of small tumors less than 4 cm increased remarkably.Concerning tumor spread, organ-confined tumors (T(1-2)N(0)M(0)) increased and distant metastasis decreased.Tumor size decreased in accordance with the progress in imaging modalities.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, The Catholic University of Korea, School of Medicine, Seoul, Korea.

ABSTRACT

Purpose: We examined changes in the clinicopathologic characteristics of renal cell carcinoma (RCC) in the past 25 years and aimed to obtain indicators for its diagnosis and treatment.

Materials and methods: The medical records of 563 patients with confirmed primary RCC after surgical treatment from 1985 to 2010 at Seoul St. Mary's Hospital were retrospectively reviewed. Patient and tumor characteristics were compared over 3 time periods (period 1: 1985-1994, period 2: 1995-2004, period 3: 2005-2010).

Results: Period 1 included 65 patients, period 2 included 183 patients, and period 3 included 315 patients, showing an exponential growth in the number of patients. Frequency was highest in the late 50s age group. The review of clinical symptoms showed that incidental diagnosis increased significantly. The tumor size at diagnosis gradually decreased and the proportion of small tumors less than 4 cm increased remarkably. Concerning tumor spread, organ-confined tumors (T(1-2)N(0)M(0)) increased and distant metastasis decreased. Histologically, the clear cell type made up the greatest proportion, about 90% in each period, but subtypes besides the clear cell type increased over the study period. The rate of nephron-sparing surgery increased, and exophytic masses were the most common.

Conclusions: Our review of the recent 25 year's worth of data on RCC from Seoul St. Mary's Hospital showed that the incidental diagnosis of RCC increased over the study period in accordance with the development of screening tests. Tumor size decreased in accordance with the progress in imaging modalities. In the future, multicenter research will be needed to analyze the characteristics of whole renal cancer in Korea.

No MeSH data available.


Related in: MedlinePlus

Age distribution of the entire group of patients studied.
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Figure 1: Age distribution of the entire group of patients studied.

Mentions: The mean age of all patients was 55.6 years (range, 25-86 years), and the frequency of RCC was highest in the late 50s age group (Fig. 1). The mean age at diagnosis did not change over the time period (54.2±10.5 years, 55.2±12.2 years, and 56.1±11.8 years in the three periods, respectively, p=0.428). Also, the proportion of young (≤40 years old) patients was not statistically different among the groups (p=0.527). Reviewing the male to female ratio of all patients, disease occurrence was about two times greater in male than in female patients. There were 374 male patients and 189 female patients.


Changes in clinicopathological characteristics of renal cell carcinoma in the past 25 years: a single-center experience.

Choi JB, Yoon BI, Kim SJ, Cho HJ, Hong SH, Choi YJ, Kim SW, Hwang TK, Lee JY - Korean J Urol (2011)

Age distribution of the entire group of patients studied.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3045715&req=5

Figure 1: Age distribution of the entire group of patients studied.
Mentions: The mean age of all patients was 55.6 years (range, 25-86 years), and the frequency of RCC was highest in the late 50s age group (Fig. 1). The mean age at diagnosis did not change over the time period (54.2±10.5 years, 55.2±12.2 years, and 56.1±11.8 years in the three periods, respectively, p=0.428). Also, the proportion of young (≤40 years old) patients was not statistically different among the groups (p=0.527). Reviewing the male to female ratio of all patients, disease occurrence was about two times greater in male than in female patients. There were 374 male patients and 189 female patients.

Bottom Line: The tumor size at diagnosis gradually decreased and the proportion of small tumors less than 4 cm increased remarkably.Concerning tumor spread, organ-confined tumors (T(1-2)N(0)M(0)) increased and distant metastasis decreased.Tumor size decreased in accordance with the progress in imaging modalities.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, The Catholic University of Korea, School of Medicine, Seoul, Korea.

ABSTRACT

Purpose: We examined changes in the clinicopathologic characteristics of renal cell carcinoma (RCC) in the past 25 years and aimed to obtain indicators for its diagnosis and treatment.

Materials and methods: The medical records of 563 patients with confirmed primary RCC after surgical treatment from 1985 to 2010 at Seoul St. Mary's Hospital were retrospectively reviewed. Patient and tumor characteristics were compared over 3 time periods (period 1: 1985-1994, period 2: 1995-2004, period 3: 2005-2010).

Results: Period 1 included 65 patients, period 2 included 183 patients, and period 3 included 315 patients, showing an exponential growth in the number of patients. Frequency was highest in the late 50s age group. The review of clinical symptoms showed that incidental diagnosis increased significantly. The tumor size at diagnosis gradually decreased and the proportion of small tumors less than 4 cm increased remarkably. Concerning tumor spread, organ-confined tumors (T(1-2)N(0)M(0)) increased and distant metastasis decreased. Histologically, the clear cell type made up the greatest proportion, about 90% in each period, but subtypes besides the clear cell type increased over the study period. The rate of nephron-sparing surgery increased, and exophytic masses were the most common.

Conclusions: Our review of the recent 25 year's worth of data on RCC from Seoul St. Mary's Hospital showed that the incidental diagnosis of RCC increased over the study period in accordance with the development of screening tests. Tumor size decreased in accordance with the progress in imaging modalities. In the future, multicenter research will be needed to analyze the characteristics of whole renal cancer in Korea.

No MeSH data available.


Related in: MedlinePlus