Limits...
The developmental impact of prenatal stress, prenatal dexamethasone and postnatal social stress on physiology, behaviour and neuroanatomy of primate offspring: studies in rhesus macaque and common marmoset.

Pryce CR, Aubert Y, Maier C, Pearce PC, Fuchs E - Psychopharmacology (Berl.) (2010)

Bottom Line: Prenatal DEX was without effect on HPA activity and reduced social play and skilled motor behaviour in marmoset.Perinatal stress-related environmental events exert short- and long-term effects on HPA function, behaviour and brain status in rhesus macaque and common marmoset.The mechanisms mediating the enduring effects remain to be elucidated, with candidates including increased basal HPA function and epigenetic programming.

View Article: PubMed Central - PubMed

Affiliation: Behavioural Neurobiology Laboratory, Swiss Federal Institute of Technology Zürich, Schwerzenbach, Switzerland.

ABSTRACT

Rationale: Exposure of the immature mammalian brain to stress factors, including stress levels of glucocorticoids, either prenatally or postnatally, is regarded as a major regulatory factor in short- and long-term brain function and, in human, as a major aetiological factor in neuropsychiatric disorders. Experimental human studies are not feasible and animal studies are required to demonstrate causality and elucidate mechanisms. A number of studies have been conducted and reviewed in rodents but there are relatively few studies in primates.

Objectives: Here we present an overview of our published studies and some original data on the effects of: (1) prenatal stress on hypothalamic-pituitary-adrenal (HPA) re/activity and hippocampus neuroanatomy in juvenile-adolescent rhesus macaques; (2) prenatal dexamethasone (DEX) on HPA activity, behaviour and prefrontal cortex neuroanatomy in infant-adolescent common marmosets; (3) postnatal daily parental separation stress on HPA re/activity, behaviour, sleep and hippocampus and prefrontal cortex neuroanatomy in infant-adolescent common marmoset.

Results: Prenatal stress increased basal cortisol levels and reduced neurogenesis in macaque. Prenatal DEX was without effect on HPA activity and reduced social play and skilled motor behaviour in marmoset. Postnatal social stress increased basal cortisol levels, reduced social play, increased awakening and reduced hippocampal glucocorticoid and mineralocorticoid receptor expression in marmoset.

Conclusions: Perinatal stress-related environmental events exert short- and long-term effects on HPA function, behaviour and brain status in rhesus macaque and common marmoset. The mechanisms mediating the enduring effects remain to be elucidated, with candidates including increased basal HPA function and epigenetic programming.

Show MeSH

Related in: MedlinePlus

Nocturnal electrocorticographic (upper trace) and electromyographic (lower trace) signals characteristic of two different sleep stages as measured in freely moving juvenile common marmosets. a ECoG and EMG traces interpreted as typical for slow-wave sleep (stage 4) b ECoG and EMG traces interpreted as typical for rapid eye movement sleep
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3045510&req=5

Fig9: Nocturnal electrocorticographic (upper trace) and electromyographic (lower trace) signals characteristic of two different sleep stages as measured in freely moving juvenile common marmosets. a ECoG and EMG traces interpreted as typical for slow-wave sleep (stage 4) b ECoG and EMG traces interpreted as typical for rapid eye movement sleep

Mentions: Subjects’ behaviour, e.g. time spent mobile and time spent in social play, had recovered to pre-surgery levels by the 2nd–3rd week after surgery. Examples of the EcoG signals that defined specific sleep stages are given in Fig. 9. Sleep was scored according to the rules developed by Rechtschaffen and Kales (Rechtschaffen and Kales 1968) for the scoring of sleep in humans, with minor modifications. The ECoG stages identified were awake, rapid eye movement (REM) sleep, light sleep (stages 1 and 2), and slow-wave sleep (SWS) (stages 3 and 4).Fig. 9


The developmental impact of prenatal stress, prenatal dexamethasone and postnatal social stress on physiology, behaviour and neuroanatomy of primate offspring: studies in rhesus macaque and common marmoset.

Pryce CR, Aubert Y, Maier C, Pearce PC, Fuchs E - Psychopharmacology (Berl.) (2010)

Nocturnal electrocorticographic (upper trace) and electromyographic (lower trace) signals characteristic of two different sleep stages as measured in freely moving juvenile common marmosets. a ECoG and EMG traces interpreted as typical for slow-wave sleep (stage 4) b ECoG and EMG traces interpreted as typical for rapid eye movement sleep
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3045510&req=5

Fig9: Nocturnal electrocorticographic (upper trace) and electromyographic (lower trace) signals characteristic of two different sleep stages as measured in freely moving juvenile common marmosets. a ECoG and EMG traces interpreted as typical for slow-wave sleep (stage 4) b ECoG and EMG traces interpreted as typical for rapid eye movement sleep
Mentions: Subjects’ behaviour, e.g. time spent mobile and time spent in social play, had recovered to pre-surgery levels by the 2nd–3rd week after surgery. Examples of the EcoG signals that defined specific sleep stages are given in Fig. 9. Sleep was scored according to the rules developed by Rechtschaffen and Kales (Rechtschaffen and Kales 1968) for the scoring of sleep in humans, with minor modifications. The ECoG stages identified were awake, rapid eye movement (REM) sleep, light sleep (stages 1 and 2), and slow-wave sleep (SWS) (stages 3 and 4).Fig. 9

Bottom Line: Prenatal DEX was without effect on HPA activity and reduced social play and skilled motor behaviour in marmoset.Perinatal stress-related environmental events exert short- and long-term effects on HPA function, behaviour and brain status in rhesus macaque and common marmoset.The mechanisms mediating the enduring effects remain to be elucidated, with candidates including increased basal HPA function and epigenetic programming.

View Article: PubMed Central - PubMed

Affiliation: Behavioural Neurobiology Laboratory, Swiss Federal Institute of Technology Zürich, Schwerzenbach, Switzerland.

ABSTRACT

Rationale: Exposure of the immature mammalian brain to stress factors, including stress levels of glucocorticoids, either prenatally or postnatally, is regarded as a major regulatory factor in short- and long-term brain function and, in human, as a major aetiological factor in neuropsychiatric disorders. Experimental human studies are not feasible and animal studies are required to demonstrate causality and elucidate mechanisms. A number of studies have been conducted and reviewed in rodents but there are relatively few studies in primates.

Objectives: Here we present an overview of our published studies and some original data on the effects of: (1) prenatal stress on hypothalamic-pituitary-adrenal (HPA) re/activity and hippocampus neuroanatomy in juvenile-adolescent rhesus macaques; (2) prenatal dexamethasone (DEX) on HPA activity, behaviour and prefrontal cortex neuroanatomy in infant-adolescent common marmosets; (3) postnatal daily parental separation stress on HPA re/activity, behaviour, sleep and hippocampus and prefrontal cortex neuroanatomy in infant-adolescent common marmoset.

Results: Prenatal stress increased basal cortisol levels and reduced neurogenesis in macaque. Prenatal DEX was without effect on HPA activity and reduced social play and skilled motor behaviour in marmoset. Postnatal social stress increased basal cortisol levels, reduced social play, increased awakening and reduced hippocampal glucocorticoid and mineralocorticoid receptor expression in marmoset.

Conclusions: Perinatal stress-related environmental events exert short- and long-term effects on HPA function, behaviour and brain status in rhesus macaque and common marmoset. The mechanisms mediating the enduring effects remain to be elucidated, with candidates including increased basal HPA function and epigenetic programming.

Show MeSH
Related in: MedlinePlus