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Sex differences in social interaction behavior following social defeat stress in the monogamous California mouse (Peromyscus californicus).

Trainor BC, Pride MC, Villalon Landeros R, Knoblauch NW, Takahashi EY, Silva AL, Crean KK - PLoS ONE (2011)

Bottom Line: Social defeat reduced social interaction responses in females but not males.This effect of defeat was not observed in males.The effects of defeat in females were limited to social contexts, as there were no differences in exploratory behavior in the open field or light-dark box test.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of California Davis, Davis, California, United States of America. bctrainor@ucdavis.edu

ABSTRACT
Stressful life experiences are known to be a precipitating factor for many mental disorders. The social defeat model induces behavioral responses in rodents (e.g. reduced social interaction) that are similar to behavioral patterns associated with mood disorders. The model has contributed to the discovery of novel mechanisms regulating behavioral responses to stress, but its utility has been largely limited to males. This is disadvantageous because most mood disorders have a higher incidence in women versus men. Male and female California mice (Peromyscus californicus) aggressively defend territories, which allowed us to observe the effects of social defeat in both sexes. In two experiments, mice were exposed to three social defeat or control episodes. Mice were then behaviorally phenotyped, and indirect markers of brain activity and corticosterone responses to a novel social stimulus were assessed. Sex differences in behavioral responses to social stress were long lasting (4 wks). Social defeat reduced social interaction responses in females but not males. In females, social defeat induced an increase in the number of phosphorylated CREB positive cells in the nucleus accumbens shell after exposure to a novel social stimulus. This effect of defeat was not observed in males. The effects of defeat in females were limited to social contexts, as there were no differences in exploratory behavior in the open field or light-dark box test. These data suggest that California mice could be a useful model for studying sex differences in behavioral responses to stress, particularly in neurobiological mechanisms that are involved with the regulation of social behavior.

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Effects of social defeat on corticosterone.Social defeat increased baseline corticosterone in males but not females during both the inactive (A) and active (B) phases. *, ** Mann-Whitney effect of stress p<0.05, p<0.01 respectively. † Mann-Whitney sex difference in controls p<0.05. All data are mean±s.e.
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pone-0017405-g009: Effects of social defeat on corticosterone.Social defeat increased baseline corticosterone in males but not females during both the inactive (A) and active (B) phases. *, ** Mann-Whitney effect of stress p<0.05, p<0.01 respectively. † Mann-Whitney sex difference in controls p<0.05. All data are mean±s.e.

Mentions: During the light (inactive, nadir) phase, stressed males had higher baseline corticosterone levels than control males (Fig. 9a, Mann-Whitney U, p<0.05) but there was no effect of stress on females. Control females also had higher corticosterone than control males (Mann-Whitney U, p<0.05) in the light phase. In the dark (active, apex) phase stressed males had higher corticosterone levels than control males (Fig. 9b, Mann-Whitney U, p<0.05) and there was no effect of stress in females. There was no significant difference in corticosterone between control males and females during the dark phase.


Sex differences in social interaction behavior following social defeat stress in the monogamous California mouse (Peromyscus californicus).

Trainor BC, Pride MC, Villalon Landeros R, Knoblauch NW, Takahashi EY, Silva AL, Crean KK - PLoS ONE (2011)

Effects of social defeat on corticosterone.Social defeat increased baseline corticosterone in males but not females during both the inactive (A) and active (B) phases. *, ** Mann-Whitney effect of stress p<0.05, p<0.01 respectively. † Mann-Whitney sex difference in controls p<0.05. All data are mean±s.e.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3045459&req=5

pone-0017405-g009: Effects of social defeat on corticosterone.Social defeat increased baseline corticosterone in males but not females during both the inactive (A) and active (B) phases. *, ** Mann-Whitney effect of stress p<0.05, p<0.01 respectively. † Mann-Whitney sex difference in controls p<0.05. All data are mean±s.e.
Mentions: During the light (inactive, nadir) phase, stressed males had higher baseline corticosterone levels than control males (Fig. 9a, Mann-Whitney U, p<0.05) but there was no effect of stress on females. Control females also had higher corticosterone than control males (Mann-Whitney U, p<0.05) in the light phase. In the dark (active, apex) phase stressed males had higher corticosterone levels than control males (Fig. 9b, Mann-Whitney U, p<0.05) and there was no effect of stress in females. There was no significant difference in corticosterone between control males and females during the dark phase.

Bottom Line: Social defeat reduced social interaction responses in females but not males.This effect of defeat was not observed in males.The effects of defeat in females were limited to social contexts, as there were no differences in exploratory behavior in the open field or light-dark box test.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of California Davis, Davis, California, United States of America. bctrainor@ucdavis.edu

ABSTRACT
Stressful life experiences are known to be a precipitating factor for many mental disorders. The social defeat model induces behavioral responses in rodents (e.g. reduced social interaction) that are similar to behavioral patterns associated with mood disorders. The model has contributed to the discovery of novel mechanisms regulating behavioral responses to stress, but its utility has been largely limited to males. This is disadvantageous because most mood disorders have a higher incidence in women versus men. Male and female California mice (Peromyscus californicus) aggressively defend territories, which allowed us to observe the effects of social defeat in both sexes. In two experiments, mice were exposed to three social defeat or control episodes. Mice were then behaviorally phenotyped, and indirect markers of brain activity and corticosterone responses to a novel social stimulus were assessed. Sex differences in behavioral responses to social stress were long lasting (4 wks). Social defeat reduced social interaction responses in females but not males. In females, social defeat induced an increase in the number of phosphorylated CREB positive cells in the nucleus accumbens shell after exposure to a novel social stimulus. This effect of defeat was not observed in males. The effects of defeat in females were limited to social contexts, as there were no differences in exploratory behavior in the open field or light-dark box test. These data suggest that California mice could be a useful model for studying sex differences in behavioral responses to stress, particularly in neurobiological mechanisms that are involved with the regulation of social behavior.

Show MeSH
Related in: MedlinePlus