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Impaired resting-state functional integrations within default mode network of generalized tonic-clonic seizures epilepsy.

Song M, Du H, Wu N, Hou B, Wu G, Wang J, Feng H, Jiang T - PLoS ONE (2011)

Bottom Line: Many recent studies have found that the ictal alterations in brain activity of the GTCS epilepsy patients are focally involved in some brain regions, including thalamus, upper brainstem, medial prefrontal cortex, posterior midbrain regions, and lateral parietal cortex.Thirteen brain areas in the DMN were extracted, and a complete undirected weighted graph was used to model the DMN for each participant.As for the nodes of the graph, we found that the degree of some brain areas within the DMN was significantly reduced in the GTCS epilepsy patients, including the anterior medial prefrontal cortex, the bilateral superior frontal cortex, and the posterior cingulate cortex.

View Article: PubMed Central - PubMed

Affiliation: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

ABSTRACT
Generalized tonic-clonic seizures (GTCS) are characterized by unresponsiveness and convulsions, which cause complete loss of consciousness. Many recent studies have found that the ictal alterations in brain activity of the GTCS epilepsy patients are focally involved in some brain regions, including thalamus, upper brainstem, medial prefrontal cortex, posterior midbrain regions, and lateral parietal cortex. Notably, many of these affected brain regions are the same and overlap considerably with the components of the so-called default mode network (DMN). Here, we hypothesize that the brain activity of the DMN of the GTCS epilepsy patients are different from normal controls, even in the resting state. To test this hypothesis, we compared the DMN of the GTCS epilepsy patients and the controls using the resting state functional magnetic resonance imaging. Thirteen brain areas in the DMN were extracted, and a complete undirected weighted graph was used to model the DMN for each participant. When directly comparing the edges of the graph, we found significant decreased functional connectivities within the DMN of the GTCS epilepsy patients comparing to the controls. As for the nodes of the graph, we found that the degree of some brain areas within the DMN was significantly reduced in the GTCS epilepsy patients, including the anterior medial prefrontal cortex, the bilateral superior frontal cortex, and the posterior cingulate cortex. Then we investigated into possible mechanisms of how GTCS epilepsy could cause the reduction of the functional integrations of DMN. We suggested the damaged functional integrations of the DMN in the GTCS epilepsy patients even during the resting state, which could help to understand the neural correlations of the impaired consciousness of GTCS epilepsy patients.

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Related in: MedlinePlus

The mean functional connectivity graph of the DMN in a pseudoanatomical organization separately for the controls group (A) and the GTCS epilepsy patients group (B).Line width is proportional to the mean connection strength between any pair of brain regions within the DMN, and node size is proportional to the mean degree of the node.
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pone-0017294-g001: The mean functional connectivity graph of the DMN in a pseudoanatomical organization separately for the controls group (A) and the GTCS epilepsy patients group (B).Line width is proportional to the mean connection strength between any pair of brain regions within the DMN, and node size is proportional to the mean degree of the node.

Mentions: In functional connectivity analysis, we found that all functional connectivities within the DMN were significantly greater than 0 in the control group (P<0.05, corrected). The mean DMN graphs respectively for the two groups were shown in Figure 1. As shown in Figure 1, the homologous bilateral brain regions showed strong functional connectivity, and the PCC showed the high degree.


Impaired resting-state functional integrations within default mode network of generalized tonic-clonic seizures epilepsy.

Song M, Du H, Wu N, Hou B, Wu G, Wang J, Feng H, Jiang T - PLoS ONE (2011)

The mean functional connectivity graph of the DMN in a pseudoanatomical organization separately for the controls group (A) and the GTCS epilepsy patients group (B).Line width is proportional to the mean connection strength between any pair of brain regions within the DMN, and node size is proportional to the mean degree of the node.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3045438&req=5

pone-0017294-g001: The mean functional connectivity graph of the DMN in a pseudoanatomical organization separately for the controls group (A) and the GTCS epilepsy patients group (B).Line width is proportional to the mean connection strength between any pair of brain regions within the DMN, and node size is proportional to the mean degree of the node.
Mentions: In functional connectivity analysis, we found that all functional connectivities within the DMN were significantly greater than 0 in the control group (P<0.05, corrected). The mean DMN graphs respectively for the two groups were shown in Figure 1. As shown in Figure 1, the homologous bilateral brain regions showed strong functional connectivity, and the PCC showed the high degree.

Bottom Line: Many recent studies have found that the ictal alterations in brain activity of the GTCS epilepsy patients are focally involved in some brain regions, including thalamus, upper brainstem, medial prefrontal cortex, posterior midbrain regions, and lateral parietal cortex.Thirteen brain areas in the DMN were extracted, and a complete undirected weighted graph was used to model the DMN for each participant.As for the nodes of the graph, we found that the degree of some brain areas within the DMN was significantly reduced in the GTCS epilepsy patients, including the anterior medial prefrontal cortex, the bilateral superior frontal cortex, and the posterior cingulate cortex.

View Article: PubMed Central - PubMed

Affiliation: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

ABSTRACT
Generalized tonic-clonic seizures (GTCS) are characterized by unresponsiveness and convulsions, which cause complete loss of consciousness. Many recent studies have found that the ictal alterations in brain activity of the GTCS epilepsy patients are focally involved in some brain regions, including thalamus, upper brainstem, medial prefrontal cortex, posterior midbrain regions, and lateral parietal cortex. Notably, many of these affected brain regions are the same and overlap considerably with the components of the so-called default mode network (DMN). Here, we hypothesize that the brain activity of the DMN of the GTCS epilepsy patients are different from normal controls, even in the resting state. To test this hypothesis, we compared the DMN of the GTCS epilepsy patients and the controls using the resting state functional magnetic resonance imaging. Thirteen brain areas in the DMN were extracted, and a complete undirected weighted graph was used to model the DMN for each participant. When directly comparing the edges of the graph, we found significant decreased functional connectivities within the DMN of the GTCS epilepsy patients comparing to the controls. As for the nodes of the graph, we found that the degree of some brain areas within the DMN was significantly reduced in the GTCS epilepsy patients, including the anterior medial prefrontal cortex, the bilateral superior frontal cortex, and the posterior cingulate cortex. Then we investigated into possible mechanisms of how GTCS epilepsy could cause the reduction of the functional integrations of DMN. We suggested the damaged functional integrations of the DMN in the GTCS epilepsy patients even during the resting state, which could help to understand the neural correlations of the impaired consciousness of GTCS epilepsy patients.

Show MeSH
Related in: MedlinePlus