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Research options for controlling zoonotic disease in India, 2010-2015.

Sekar N, Shah NK, Abbas SS, Kakkar M, Roadmap to Combat Zoonoses in India Initiati - PLoS ONE (2011)

Bottom Line: Zoonotic infections pose a significant public health challenge for low- and middle-income countries and have traditionally been a neglected area of research.Priority setting methods developed by the Child Health and Nutrition Research Initiative were adapted for the diversity of sectors, disciplines, diseases and populations relevant for zoonoses in India.The scores were weighted using relative ranks among the criteria based upon the feedback of a larger reference group.

View Article: PubMed Central - PubMed

Affiliation: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America.

ABSTRACT

Background: Zoonotic infections pose a significant public health challenge for low- and middle-income countries and have traditionally been a neglected area of research. The Roadmap to Combat Zoonoses in India (RCZI) initiative conducted an exercise to systematically identify and prioritize research options needed to control zoonoses in India.

Methods and findings: Priority setting methods developed by the Child Health and Nutrition Research Initiative were adapted for the diversity of sectors, disciplines, diseases and populations relevant for zoonoses in India. A multidisciplinary group of experts identified priority zoonotic diseases and knowledge gaps and proposed research options to address key knowledge gaps within the next five years. Each option was scored using predefined criteria by another group of experts. The scores were weighted using relative ranks among the criteria based upon the feedback of a larger reference group. We categorized each research option by type of research, disease targeted, factorials, and level of collaboration required. We analysed the research options by tabulating them along these categories. Seventeen experts generated four universal research themes and 103 specific research options, the majority of which required a high to medium level of collaboration across sectors. Research options designated as pertaining to 'social, political and economic' factorials predominated and scored higher than options focussing on ecological, genetic and biological, or environmental factors. Research options related to 'health policy and systems' scored highest while those related to 'research for development of new interventions' scored the lowest.

Conclusions: We methodically identified research themes and specific research options incorporating perspectives of a diverse group of stakeholders. These outputs reflect the diverse nature of challenges posed by zoonoses and should be acceptable across diseases, disciplines, and sectors. The identified research options capture the need for 'actionable research' for advancing the prevention and control of zoonoses in India.

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Average Score and Frequency of Research Options by (A) Instrument of Health Research (IHR); and (B) Factorial.Y Axis represents the average weighted score and the size of bubble represents frequency for each category of research option.
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pone-0017120-g003: Average Score and Frequency of Research Options by (A) Instrument of Health Research (IHR); and (B) Factorial.Y Axis represents the average weighted score and the size of bubble represents frequency for each category of research option.

Mentions: The research options were scored by five independent experts. The average raw score, on a scale of zero to one, was 0.78, with 0.35 as the lowest and 0.96 as the highest score. The research options scored lower on average in the categories of “maximum potential for disease reduction” and in “equity in achieved disease burden reduction” than in the other three criteria. The top fifteen research options covered a wide range of diseases, populations, commodities, types of research, and levels of collaboration (Table 3). Options related to health policy & systems research and research to improve existing interventions received higher scores on average (0.81 & 0.80, respectively) than the options focusing on epidemiologic research and research related to development of new interventions (0.78 & 0.76, respectively) (Table 2, Figure 3).


Research options for controlling zoonotic disease in India, 2010-2015.

Sekar N, Shah NK, Abbas SS, Kakkar M, Roadmap to Combat Zoonoses in India Initiati - PLoS ONE (2011)

Average Score and Frequency of Research Options by (A) Instrument of Health Research (IHR); and (B) Factorial.Y Axis represents the average weighted score and the size of bubble represents frequency for each category of research option.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3045424&req=5

pone-0017120-g003: Average Score and Frequency of Research Options by (A) Instrument of Health Research (IHR); and (B) Factorial.Y Axis represents the average weighted score and the size of bubble represents frequency for each category of research option.
Mentions: The research options were scored by five independent experts. The average raw score, on a scale of zero to one, was 0.78, with 0.35 as the lowest and 0.96 as the highest score. The research options scored lower on average in the categories of “maximum potential for disease reduction” and in “equity in achieved disease burden reduction” than in the other three criteria. The top fifteen research options covered a wide range of diseases, populations, commodities, types of research, and levels of collaboration (Table 3). Options related to health policy & systems research and research to improve existing interventions received higher scores on average (0.81 & 0.80, respectively) than the options focusing on epidemiologic research and research related to development of new interventions (0.78 & 0.76, respectively) (Table 2, Figure 3).

Bottom Line: Zoonotic infections pose a significant public health challenge for low- and middle-income countries and have traditionally been a neglected area of research.Priority setting methods developed by the Child Health and Nutrition Research Initiative were adapted for the diversity of sectors, disciplines, diseases and populations relevant for zoonoses in India.The scores were weighted using relative ranks among the criteria based upon the feedback of a larger reference group.

View Article: PubMed Central - PubMed

Affiliation: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America.

ABSTRACT

Background: Zoonotic infections pose a significant public health challenge for low- and middle-income countries and have traditionally been a neglected area of research. The Roadmap to Combat Zoonoses in India (RCZI) initiative conducted an exercise to systematically identify and prioritize research options needed to control zoonoses in India.

Methods and findings: Priority setting methods developed by the Child Health and Nutrition Research Initiative were adapted for the diversity of sectors, disciplines, diseases and populations relevant for zoonoses in India. A multidisciplinary group of experts identified priority zoonotic diseases and knowledge gaps and proposed research options to address key knowledge gaps within the next five years. Each option was scored using predefined criteria by another group of experts. The scores were weighted using relative ranks among the criteria based upon the feedback of a larger reference group. We categorized each research option by type of research, disease targeted, factorials, and level of collaboration required. We analysed the research options by tabulating them along these categories. Seventeen experts generated four universal research themes and 103 specific research options, the majority of which required a high to medium level of collaboration across sectors. Research options designated as pertaining to 'social, political and economic' factorials predominated and scored higher than options focussing on ecological, genetic and biological, or environmental factors. Research options related to 'health policy and systems' scored highest while those related to 'research for development of new interventions' scored the lowest.

Conclusions: We methodically identified research themes and specific research options incorporating perspectives of a diverse group of stakeholders. These outputs reflect the diverse nature of challenges posed by zoonoses and should be acceptable across diseases, disciplines, and sectors. The identified research options capture the need for 'actionable research' for advancing the prevention and control of zoonoses in India.

Show MeSH
Related in: MedlinePlus