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Research options for controlling zoonotic disease in India, 2010-2015.

Sekar N, Shah NK, Abbas SS, Kakkar M, Roadmap to Combat Zoonoses in India Initiati - PLoS ONE (2011)

Bottom Line: Zoonotic infections pose a significant public health challenge for low- and middle-income countries and have traditionally been a neglected area of research.Priority setting methods developed by the Child Health and Nutrition Research Initiative were adapted for the diversity of sectors, disciplines, diseases and populations relevant for zoonoses in India.The scores were weighted using relative ranks among the criteria based upon the feedback of a larger reference group.

View Article: PubMed Central - PubMed

Affiliation: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America.

ABSTRACT

Background: Zoonotic infections pose a significant public health challenge for low- and middle-income countries and have traditionally been a neglected area of research. The Roadmap to Combat Zoonoses in India (RCZI) initiative conducted an exercise to systematically identify and prioritize research options needed to control zoonoses in India.

Methods and findings: Priority setting methods developed by the Child Health and Nutrition Research Initiative were adapted for the diversity of sectors, disciplines, diseases and populations relevant for zoonoses in India. A multidisciplinary group of experts identified priority zoonotic diseases and knowledge gaps and proposed research options to address key knowledge gaps within the next five years. Each option was scored using predefined criteria by another group of experts. The scores were weighted using relative ranks among the criteria based upon the feedback of a larger reference group. We categorized each research option by type of research, disease targeted, factorials, and level of collaboration required. We analysed the research options by tabulating them along these categories. Seventeen experts generated four universal research themes and 103 specific research options, the majority of which required a high to medium level of collaboration across sectors. Research options designated as pertaining to 'social, political and economic' factorials predominated and scored higher than options focussing on ecological, genetic and biological, or environmental factors. Research options related to 'health policy and systems' scored highest while those related to 'research for development of new interventions' scored the lowest.

Conclusions: We methodically identified research themes and specific research options incorporating perspectives of a diverse group of stakeholders. These outputs reflect the diverse nature of challenges posed by zoonoses and should be acceptable across diseases, disciplines, and sectors. The identified research options capture the need for 'actionable research' for advancing the prevention and control of zoonoses in India.

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Schematic of different steps used in identification of strategic research options.Adapted from: Igor Rudan, Shams El Arifeen, Robert E. Black. A Systematic Methodology for Setting Priorities in Child Health Research Investments (In A New Approach for Systematic Priority Setting In Child Health Research Investment). Child Health and Nutrition Research Initiative (CHNRI). Bangladesh 2006.
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pone-0017120-g001: Schematic of different steps used in identification of strategic research options.Adapted from: Igor Rudan, Shams El Arifeen, Robert E. Black. A Systematic Methodology for Setting Priorities in Child Health Research Investments (In A New Approach for Systematic Priority Setting In Child Health Research Investment). Child Health and Nutrition Research Initiative (CHNRI). Bangladesh 2006.

Mentions: Two groups of experts (interviewees and scorers) were selected from partner institutions of RCZI with the goal of providing inputs from different academic, policy, and sector perspectives (File S1). In order to ensure focused interviews, we asked each interviewee to identify the top five zoonotic diseases of concern in India. An exhaustive list of research options was systematically generated through interviews using an adapted version of a framework developed by CHNRI that outlines different health research areas; viz.basic epidemiological research, health policy and systems research, research to improve existing interventions, research for development of new interventions (File S2). The process was iterative, asking the interviewee to first identify key gaps in knowledge on zoonoses, and then asking for research options that could help address those gaps. Broader research options that were repeatedly identified for all diseases by many interviewees were classified as research themes (Figure 1).


Research options for controlling zoonotic disease in India, 2010-2015.

Sekar N, Shah NK, Abbas SS, Kakkar M, Roadmap to Combat Zoonoses in India Initiati - PLoS ONE (2011)

Schematic of different steps used in identification of strategic research options.Adapted from: Igor Rudan, Shams El Arifeen, Robert E. Black. A Systematic Methodology for Setting Priorities in Child Health Research Investments (In A New Approach for Systematic Priority Setting In Child Health Research Investment). Child Health and Nutrition Research Initiative (CHNRI). Bangladesh 2006.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3045424&req=5

pone-0017120-g001: Schematic of different steps used in identification of strategic research options.Adapted from: Igor Rudan, Shams El Arifeen, Robert E. Black. A Systematic Methodology for Setting Priorities in Child Health Research Investments (In A New Approach for Systematic Priority Setting In Child Health Research Investment). Child Health and Nutrition Research Initiative (CHNRI). Bangladesh 2006.
Mentions: Two groups of experts (interviewees and scorers) were selected from partner institutions of RCZI with the goal of providing inputs from different academic, policy, and sector perspectives (File S1). In order to ensure focused interviews, we asked each interviewee to identify the top five zoonotic diseases of concern in India. An exhaustive list of research options was systematically generated through interviews using an adapted version of a framework developed by CHNRI that outlines different health research areas; viz.basic epidemiological research, health policy and systems research, research to improve existing interventions, research for development of new interventions (File S2). The process was iterative, asking the interviewee to first identify key gaps in knowledge on zoonoses, and then asking for research options that could help address those gaps. Broader research options that were repeatedly identified for all diseases by many interviewees were classified as research themes (Figure 1).

Bottom Line: Zoonotic infections pose a significant public health challenge for low- and middle-income countries and have traditionally been a neglected area of research.Priority setting methods developed by the Child Health and Nutrition Research Initiative were adapted for the diversity of sectors, disciplines, diseases and populations relevant for zoonoses in India.The scores were weighted using relative ranks among the criteria based upon the feedback of a larger reference group.

View Article: PubMed Central - PubMed

Affiliation: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America.

ABSTRACT

Background: Zoonotic infections pose a significant public health challenge for low- and middle-income countries and have traditionally been a neglected area of research. The Roadmap to Combat Zoonoses in India (RCZI) initiative conducted an exercise to systematically identify and prioritize research options needed to control zoonoses in India.

Methods and findings: Priority setting methods developed by the Child Health and Nutrition Research Initiative were adapted for the diversity of sectors, disciplines, diseases and populations relevant for zoonoses in India. A multidisciplinary group of experts identified priority zoonotic diseases and knowledge gaps and proposed research options to address key knowledge gaps within the next five years. Each option was scored using predefined criteria by another group of experts. The scores were weighted using relative ranks among the criteria based upon the feedback of a larger reference group. We categorized each research option by type of research, disease targeted, factorials, and level of collaboration required. We analysed the research options by tabulating them along these categories. Seventeen experts generated four universal research themes and 103 specific research options, the majority of which required a high to medium level of collaboration across sectors. Research options designated as pertaining to 'social, political and economic' factorials predominated and scored higher than options focussing on ecological, genetic and biological, or environmental factors. Research options related to 'health policy and systems' scored highest while those related to 'research for development of new interventions' scored the lowest.

Conclusions: We methodically identified research themes and specific research options incorporating perspectives of a diverse group of stakeholders. These outputs reflect the diverse nature of challenges posed by zoonoses and should be acceptable across diseases, disciplines, and sectors. The identified research options capture the need for 'actionable research' for advancing the prevention and control of zoonoses in India.

Show MeSH
Related in: MedlinePlus