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Fallopian tube origin of supposed ovarian high-grade serous carcinomas.

Diniz PM, Carvalho JP, Baracat EC, Carvalho FM - Clinics (Sao Paulo) (2011)

Bottom Line: Fallopian tube involvement was observed in 24/34 (70.6%) cases.In 4 (11.8%) of these cases, an intraepithelial neoplasia was present, and therefore these cases were hypothesized to be primary from fallopian tubes.For an additional 7/34 (20.6%) cases, a fallopian tube origin was considered a possible primary.

View Article: PubMed Central - PubMed

Affiliation: Faculdade de Medicina, Universidade de São Paulo.

ABSTRACT

Introduction: Serous carcinomas are the most frequent histologic type of ovarian and peritoneal cancers, and can also be detected in the endometrium and fallopian tubes. Serous carcinomas are usually high-grade neoplasms when diagnosed, yet the identification of an associated precursor lesion remains challenging. Pathological examination of specimens obtained from prophylactic bilateral salpingo-oophorectomies that were performed for patients harboring BRCA1/2 mutations suggests that high-grade serous carcinomas may arise in the fallopian tubes rather than in the ovaries.

Objective: To investigate the presence and extent of fallopian tube involvement in cases of serous pelvic carcinomas.

Methods: Thirty-four cases of serous pelvic carcinoma with clinical presentations suggesting an ovarian origin were analyzed retrospectively. Histologic samples of fallopian tube tissues were available for these cases and were analyzed. Probable primary site, type of tubal involvement, tissues involved in the neoplasia and vascular involvement were evaluated.

Results: Fallopian tube involvement was observed in 24/34 (70.6%) cases. In 4 (11.8%) of these cases, an intraepithelial neoplasia was present, and therefore these cases were hypothesized to be primary from fallopian tubes. For an additional 7/34 (20.6%) cases, a fallopian tube origin was considered a possible primary.

Conclusions: Fallopian tubes can be the primary site for a subset of pelvic high-grade serous carcinomas.

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Related in: MedlinePlus

Fimbria region of the fallopian tube showing abrupt transition between mesothelial lining and intraepithelial neoplasia. Hematoxylin‐eosin. Original magnification 100×.
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f1-cln_66p73: Fimbria region of the fallopian tube showing abrupt transition between mesothelial lining and intraepithelial neoplasia. Hematoxylin‐eosin. Original magnification 100×.

Mentions: The distribution of cases according to primary tumor site and tubal involvement is presented in Table 2. Fallopian tube involvement was identified in 24/34 (70.6%) cases, and tubal serosa was involved in 23/24 cases. Furthermore, in 4/24 (16.7%) cases, the intraepithelial serous carcinoma could be identified (Figure 1). For the other 20 cases, serous neoplasia was associated with infiltration of the fallopian tube wall (n = 17), exclusive serous involvement (n = 2) and intraluminal neoplasia without an observable connection to the tubal wall (n = 1). In addition, there were 2 cases where the origin of the neoplasia was clearly localized to the fimbriae and, in 4 cases, the intraepithelial neoplasia characterized the origin in the fallopian tube. Seven other cases had tubal involvement associated with either the peritoneum (n = 5) or the ovary plus the peritoneum (n = 2). However, these cases were classified as indeterminate, although there was a high probability that these neoplasias were associated with a primary tubal tumor. Furthermore, in 2 of these cases, involvement of the fimbriae region was evident.


Fallopian tube origin of supposed ovarian high-grade serous carcinomas.

Diniz PM, Carvalho JP, Baracat EC, Carvalho FM - Clinics (Sao Paulo) (2011)

Fimbria region of the fallopian tube showing abrupt transition between mesothelial lining and intraepithelial neoplasia. Hematoxylin‐eosin. Original magnification 100×.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3044587&req=5

f1-cln_66p73: Fimbria region of the fallopian tube showing abrupt transition between mesothelial lining and intraepithelial neoplasia. Hematoxylin‐eosin. Original magnification 100×.
Mentions: The distribution of cases according to primary tumor site and tubal involvement is presented in Table 2. Fallopian tube involvement was identified in 24/34 (70.6%) cases, and tubal serosa was involved in 23/24 cases. Furthermore, in 4/24 (16.7%) cases, the intraepithelial serous carcinoma could be identified (Figure 1). For the other 20 cases, serous neoplasia was associated with infiltration of the fallopian tube wall (n = 17), exclusive serous involvement (n = 2) and intraluminal neoplasia without an observable connection to the tubal wall (n = 1). In addition, there were 2 cases where the origin of the neoplasia was clearly localized to the fimbriae and, in 4 cases, the intraepithelial neoplasia characterized the origin in the fallopian tube. Seven other cases had tubal involvement associated with either the peritoneum (n = 5) or the ovary plus the peritoneum (n = 2). However, these cases were classified as indeterminate, although there was a high probability that these neoplasias were associated with a primary tubal tumor. Furthermore, in 2 of these cases, involvement of the fimbriae region was evident.

Bottom Line: Fallopian tube involvement was observed in 24/34 (70.6%) cases.In 4 (11.8%) of these cases, an intraepithelial neoplasia was present, and therefore these cases were hypothesized to be primary from fallopian tubes.For an additional 7/34 (20.6%) cases, a fallopian tube origin was considered a possible primary.

View Article: PubMed Central - PubMed

Affiliation: Faculdade de Medicina, Universidade de São Paulo.

ABSTRACT

Introduction: Serous carcinomas are the most frequent histologic type of ovarian and peritoneal cancers, and can also be detected in the endometrium and fallopian tubes. Serous carcinomas are usually high-grade neoplasms when diagnosed, yet the identification of an associated precursor lesion remains challenging. Pathological examination of specimens obtained from prophylactic bilateral salpingo-oophorectomies that were performed for patients harboring BRCA1/2 mutations suggests that high-grade serous carcinomas may arise in the fallopian tubes rather than in the ovaries.

Objective: To investigate the presence and extent of fallopian tube involvement in cases of serous pelvic carcinomas.

Methods: Thirty-four cases of serous pelvic carcinoma with clinical presentations suggesting an ovarian origin were analyzed retrospectively. Histologic samples of fallopian tube tissues were available for these cases and were analyzed. Probable primary site, type of tubal involvement, tissues involved in the neoplasia and vascular involvement were evaluated.

Results: Fallopian tube involvement was observed in 24/34 (70.6%) cases. In 4 (11.8%) of these cases, an intraepithelial neoplasia was present, and therefore these cases were hypothesized to be primary from fallopian tubes. For an additional 7/34 (20.6%) cases, a fallopian tube origin was considered a possible primary.

Conclusions: Fallopian tubes can be the primary site for a subset of pelvic high-grade serous carcinomas.

Show MeSH
Related in: MedlinePlus