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Aleutian mink disease virus and humans.

Jepsen JR, d'Amore F, Baandrup U, Clausen MR, Gottschalck E, Aasted B - Emerging Infect. Dis. (2009)

Bottom Line: Reports of a possible relationship between Aleutian mink disease parvovirus (AMDV) and human infection are rare.However, 2 mink farmers with vascular disease and microangiopathy similar to that in mink with Aleutian disease were found to have AMDV-specific antibodies and AMDV DNA.These findings raise the suspicion that AMDV may play a role in human disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Occupational Medicine, Hospital of South-Western Jutland, Østergade 81-83, DK-6700 Esbjerg, Denmark. joergen.riis.jepsen@svs.regionsyddanmark.dk

ABSTRACT
Reports of a possible relationship between Aleutian mink disease parvovirus (AMDV) and human infection are rare. However, 2 mink farmers with vascular disease and microangiopathy similar to that in mink with Aleutian disease were found to have AMDV-specific antibodies and AMDV DNA. These findings raise the suspicion that AMDV may play a role in human disease.

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Histopathologic appearance of renal biopsy sample from 54-year-old mink farmer in Denmark who had been exposed to Aleutian mink disease parvovirus−infected mink for 34 years (patient 2). A) Glomeruli with hypercellularity and crescents. Original magnification ×20. B) Electron microscopy showing distinct extracellular deposits of coarse 20-nm fibrils (microtubular structures) characterized as immunotactoid glomerulopathy. Original magnification ×100,000.
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Figure 2: Histopathologic appearance of renal biopsy sample from 54-year-old mink farmer in Denmark who had been exposed to Aleutian mink disease parvovirus−infected mink for 34 years (patient 2). A) Glomeruli with hypercellularity and crescents. Original magnification ×20. B) Electron microscopy showing distinct extracellular deposits of coarse 20-nm fibrils (microtubular structures) characterized as immunotactoid glomerulopathy. Original magnification ×100,000.

Mentions: Patient 2 was also a mink farmer. He had been exposed to AMDV since the age of 20. At 54 years of age, 2 years after an extensive outbreak of AMDV among his mink, he was hospitalized for chronic glomerulonephritis. A renal biopsy sample showed endocapillary and mesangial proliferative glomerulonephritis with abundant focal semilunes (Figure 2, panel A). Immunofluorescence showed anti-immunoglobulin M and anti-C3 antibodies localized to the renal capillaries. Electron microscopy showed organized fibrillar deposits of stacked microtubules of ≈20 nm (Figure 2, panel B), consistent with fibrillary glomerulonephritis (14), an idiopathic condition characterized by polyclonal immune deposits with restricted gamma isotypes. No seroimmunologic information was available for the patient at this time. Immunosuppression improved his renal function, and he remained stable while receiving continuous immunosuppressive medication.


Aleutian mink disease virus and humans.

Jepsen JR, d'Amore F, Baandrup U, Clausen MR, Gottschalck E, Aasted B - Emerging Infect. Dis. (2009)

Histopathologic appearance of renal biopsy sample from 54-year-old mink farmer in Denmark who had been exposed to Aleutian mink disease parvovirus−infected mink for 34 years (patient 2). A) Glomeruli with hypercellularity and crescents. Original magnification ×20. B) Electron microscopy showing distinct extracellular deposits of coarse 20-nm fibrils (microtubular structures) characterized as immunotactoid glomerulopathy. Original magnification ×100,000.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3044528&req=5

Figure 2: Histopathologic appearance of renal biopsy sample from 54-year-old mink farmer in Denmark who had been exposed to Aleutian mink disease parvovirus−infected mink for 34 years (patient 2). A) Glomeruli with hypercellularity and crescents. Original magnification ×20. B) Electron microscopy showing distinct extracellular deposits of coarse 20-nm fibrils (microtubular structures) characterized as immunotactoid glomerulopathy. Original magnification ×100,000.
Mentions: Patient 2 was also a mink farmer. He had been exposed to AMDV since the age of 20. At 54 years of age, 2 years after an extensive outbreak of AMDV among his mink, he was hospitalized for chronic glomerulonephritis. A renal biopsy sample showed endocapillary and mesangial proliferative glomerulonephritis with abundant focal semilunes (Figure 2, panel A). Immunofluorescence showed anti-immunoglobulin M and anti-C3 antibodies localized to the renal capillaries. Electron microscopy showed organized fibrillar deposits of stacked microtubules of ≈20 nm (Figure 2, panel B), consistent with fibrillary glomerulonephritis (14), an idiopathic condition characterized by polyclonal immune deposits with restricted gamma isotypes. No seroimmunologic information was available for the patient at this time. Immunosuppression improved his renal function, and he remained stable while receiving continuous immunosuppressive medication.

Bottom Line: Reports of a possible relationship between Aleutian mink disease parvovirus (AMDV) and human infection are rare.However, 2 mink farmers with vascular disease and microangiopathy similar to that in mink with Aleutian disease were found to have AMDV-specific antibodies and AMDV DNA.These findings raise the suspicion that AMDV may play a role in human disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Occupational Medicine, Hospital of South-Western Jutland, Østergade 81-83, DK-6700 Esbjerg, Denmark. joergen.riis.jepsen@svs.regionsyddanmark.dk

ABSTRACT
Reports of a possible relationship between Aleutian mink disease parvovirus (AMDV) and human infection are rare. However, 2 mink farmers with vascular disease and microangiopathy similar to that in mink with Aleutian disease were found to have AMDV-specific antibodies and AMDV DNA. These findings raise the suspicion that AMDV may play a role in human disease.

Show MeSH
Related in: MedlinePlus