Limits...
Design and evaluation of fast dissolving tablets of clonazepam.

Shirsand SB, Suresh S, Swamy PV, Kumar DN, Rampure MV - Indian J Pharm Sci (2008)

Bottom Line: Based on in vitro dispersion time (approximately 13 s), three formulations were tested for the in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40°/75% relative humidity for 6 mo) and drug-excipient interaction (IR spectroscopy).Among the three promising formulations, the formulation prepared by using 10% w/w of crospovidone and 35% w/w of microcrystalline cellulose emerged as the overall best formulation (t(50%) 1.8 min) based on the in vitro drug release characteristics compared to conventional commercial tablet formulation (t(50%) 16.4 min).Short-term stability studies on the formulations indicated that there were no significant changes in drug content and in vitro dispersion time (P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, H. K. E. Society's College of Pharmacy, Sedam Road, Gulbarga-585 105, India.

ABSTRACT
In the present work, fast dissolving tablets of clonazepam were prepared by direct compression method with a view to enhance patient compliance. Three super-disintegrants, viz., crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios with microcrystalline cellulose (Avicel PH-102) along with directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time (approximately 13 s), three formulations were tested for the in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40°/75% relative humidity for 6 mo) and drug-excipient interaction (IR spectroscopy). Among the three promising formulations, the formulation prepared by using 10% w/w of crospovidone and 35% w/w of microcrystalline cellulose emerged as the overall best formulation (t(50%) 1.8 min) based on the in vitro drug release characteristics compared to conventional commercial tablet formulation (t(50%) 16.4 min). Short-term stability studies on the formulations indicated that there were no significant changes in drug content and in vitro dispersion time (P<0.05).

No MeSH data available.


In vitro cumulative percent drug release from promising clonazepam formulationsIn vitro cumulative percent drug release Vs time profiles of promising clonazepam  formulations  DC0 (–●–),  DCP5 (–■–), DCCS5 (–▲–), DSSG5 (–●–) and CCF (–*–) in pH 6.8 phosphate buffer
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3040877&req=5

Figure 0001: In vitro cumulative percent drug release from promising clonazepam formulationsIn vitro cumulative percent drug release Vs time profiles of promising clonazepam formulations DC0 (–●–), DCP5 (–■–), DCCS5 (–▲–), DSSG5 (–●–) and CCF (–*–) in pH 6.8 phosphate buffer

Mentions: In vitro dissolution studies on the promising formulations (DCP5, DCCS5 and DSSG5), the control (DC0) and commercial conventional formulations (CCF) were carried out in pH 6.8 phosphate buffer, and the various dissolution parameter values viz., percent drug dissolved in 5 min, 10 min and 15 min (D5, D10 and D15), dissolution efficiency at 10 min (DE10 min)12, t50%, t70% and t90% are shown in Table 3 and the dissolution profiles depicted in fig. 1. This data reveals that overall, the formulation DCP5 has shown ten-fold faster drug release (t50% 1.8 min) when compared to the commercial conventional tablet formulation of CZ (t50% 16.4 min) and released 5-times more drug than the control formulation in 10 min.


Design and evaluation of fast dissolving tablets of clonazepam.

Shirsand SB, Suresh S, Swamy PV, Kumar DN, Rampure MV - Indian J Pharm Sci (2008)

In vitro cumulative percent drug release from promising clonazepam formulationsIn vitro cumulative percent drug release Vs time profiles of promising clonazepam  formulations  DC0 (–●–),  DCP5 (–■–), DCCS5 (–▲–), DSSG5 (–●–) and CCF (–*–) in pH 6.8 phosphate buffer
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3040877&req=5

Figure 0001: In vitro cumulative percent drug release from promising clonazepam formulationsIn vitro cumulative percent drug release Vs time profiles of promising clonazepam formulations DC0 (–●–), DCP5 (–■–), DCCS5 (–▲–), DSSG5 (–●–) and CCF (–*–) in pH 6.8 phosphate buffer
Mentions: In vitro dissolution studies on the promising formulations (DCP5, DCCS5 and DSSG5), the control (DC0) and commercial conventional formulations (CCF) were carried out in pH 6.8 phosphate buffer, and the various dissolution parameter values viz., percent drug dissolved in 5 min, 10 min and 15 min (D5, D10 and D15), dissolution efficiency at 10 min (DE10 min)12, t50%, t70% and t90% are shown in Table 3 and the dissolution profiles depicted in fig. 1. This data reveals that overall, the formulation DCP5 has shown ten-fold faster drug release (t50% 1.8 min) when compared to the commercial conventional tablet formulation of CZ (t50% 16.4 min) and released 5-times more drug than the control formulation in 10 min.

Bottom Line: Based on in vitro dispersion time (approximately 13 s), three formulations were tested for the in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40°/75% relative humidity for 6 mo) and drug-excipient interaction (IR spectroscopy).Among the three promising formulations, the formulation prepared by using 10% w/w of crospovidone and 35% w/w of microcrystalline cellulose emerged as the overall best formulation (t(50%) 1.8 min) based on the in vitro drug release characteristics compared to conventional commercial tablet formulation (t(50%) 16.4 min).Short-term stability studies on the formulations indicated that there were no significant changes in drug content and in vitro dispersion time (P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, H. K. E. Society's College of Pharmacy, Sedam Road, Gulbarga-585 105, India.

ABSTRACT
In the present work, fast dissolving tablets of clonazepam were prepared by direct compression method with a view to enhance patient compliance. Three super-disintegrants, viz., crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios with microcrystalline cellulose (Avicel PH-102) along with directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time (approximately 13 s), three formulations were tested for the in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40°/75% relative humidity for 6 mo) and drug-excipient interaction (IR spectroscopy). Among the three promising formulations, the formulation prepared by using 10% w/w of crospovidone and 35% w/w of microcrystalline cellulose emerged as the overall best formulation (t(50%) 1.8 min) based on the in vitro drug release characteristics compared to conventional commercial tablet formulation (t(50%) 16.4 min). Short-term stability studies on the formulations indicated that there were no significant changes in drug content and in vitro dispersion time (P<0.05).

No MeSH data available.