Limits...
pH-Induced In Situ Gel for Periodontal Anesthesia.

Gupta H, Singh RM, Singh GN, Kaushik D, Sharma A - Indian J Pharm Sci (2008)

Bottom Line: A pH mediated in situ gelling system was developed using prilocaine hydrochloride for periodontal anesthesia using combination of chitosan and hydroxypropylmethylcellulose.The gel so developed can be used as anaesthetic in lengthy dental surgery.Gel with chitosan (0.25% w/v) and hydroxypropylmethylcellulose (0.25% w/v) was found to have good gelation near pH 7.4 (pH of mucous) with prolonged action.

View Article: PubMed Central - PubMed

Affiliation: Central Indian Pharmacopoeia Laboratory, Raj Nagar, Ghaziabad-201 002, India.

ABSTRACT
A pH mediated in situ gelling system was developed using prilocaine hydrochloride for periodontal anesthesia using combination of chitosan and hydroxypropylmethylcellulose. The gel so developed can be used as anaesthetic in lengthy dental surgery. The gel was evaluated for many parameters like gelation pH, viscosity, physicochemical properties, in vitro release, sterility and stability. Gel with chitosan (0.25% w/v) and hydroxypropylmethylcellulose (0.25% w/v) was found to have good gelation near pH 7.4 (pH of mucous) with prolonged action.

No MeSH data available.


Related in: MedlinePlus

In vitro drug release from various developed formulation. Chitosan formulation F1 (–♦–), chitosan and HPMC F4 (–■–) and HPMC formulation F7 (–▲–)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3040872&req=5

Figure 0001: In vitro drug release from various developed formulation. Chitosan formulation F1 (–♦–), chitosan and HPMC F4 (–■–) and HPMC formulation F7 (–▲–)

Mentions: In vitro drug release profile of the formulation was determined in simulated fluid (pH 7.4) and the formulation displayed a slow release profile (fig. 1). Chitosan/HPMC based formulation (F4) displayed a 28.43% cumulative drug release after 2 h, 42.44% after 6 h and 96.27% after 24 h. More or less similar pattern was observed with pure chitosan based formulation (F1). Pure HPMC based formulation (F7) exhibited faster release as compared to chitosan based formulations. A cumulative 98.03% release was observed in 10 h from the pure HPMC based formulation (F7).


pH-Induced In Situ Gel for Periodontal Anesthesia.

Gupta H, Singh RM, Singh GN, Kaushik D, Sharma A - Indian J Pharm Sci (2008)

In vitro drug release from various developed formulation. Chitosan formulation F1 (–♦–), chitosan and HPMC F4 (–■–) and HPMC formulation F7 (–▲–)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3040872&req=5

Figure 0001: In vitro drug release from various developed formulation. Chitosan formulation F1 (–♦–), chitosan and HPMC F4 (–■–) and HPMC formulation F7 (–▲–)
Mentions: In vitro drug release profile of the formulation was determined in simulated fluid (pH 7.4) and the formulation displayed a slow release profile (fig. 1). Chitosan/HPMC based formulation (F4) displayed a 28.43% cumulative drug release after 2 h, 42.44% after 6 h and 96.27% after 24 h. More or less similar pattern was observed with pure chitosan based formulation (F1). Pure HPMC based formulation (F7) exhibited faster release as compared to chitosan based formulations. A cumulative 98.03% release was observed in 10 h from the pure HPMC based formulation (F7).

Bottom Line: A pH mediated in situ gelling system was developed using prilocaine hydrochloride for periodontal anesthesia using combination of chitosan and hydroxypropylmethylcellulose.The gel so developed can be used as anaesthetic in lengthy dental surgery.Gel with chitosan (0.25% w/v) and hydroxypropylmethylcellulose (0.25% w/v) was found to have good gelation near pH 7.4 (pH of mucous) with prolonged action.

View Article: PubMed Central - PubMed

Affiliation: Central Indian Pharmacopoeia Laboratory, Raj Nagar, Ghaziabad-201 002, India.

ABSTRACT
A pH mediated in situ gelling system was developed using prilocaine hydrochloride for periodontal anesthesia using combination of chitosan and hydroxypropylmethylcellulose. The gel so developed can be used as anaesthetic in lengthy dental surgery. The gel was evaluated for many parameters like gelation pH, viscosity, physicochemical properties, in vitro release, sterility and stability. Gel with chitosan (0.25% w/v) and hydroxypropylmethylcellulose (0.25% w/v) was found to have good gelation near pH 7.4 (pH of mucous) with prolonged action.

No MeSH data available.


Related in: MedlinePlus