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In situ formed phase transited drug delivery system of ketoprofen for achieving osmotic, controlled and level a in vitro in vivo correlation.

Philip AK, Pathak K - Indian J Pharm Sci (2008)

Bottom Line: In vitro release studies and statistical test for all the prepared and marketed formulation were done at P >0.05.The drug release was found to be independent of the pH, but dependent on the osmotic pressure of the dissolution medium.In vivo pharmacokinetic studies showed a level A correlation (R(2)>0.99) with 39.24 % relative bioavailability compared to immediate release tablet of ketoprofen.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh-281001, India.

ABSTRACT
A dry process induced phase transited, non disintegrating, controlled release, in situ formed asymmetric membrane capsular system for poorly water soluble drug, ketoprofen, was developed and evaluated both in vitro and in vivo for osmotic and controlled release of the drug. In situ formed asymmetric membrane capsules were prepared using fabricated glass capsule holders via dry, phase inversion process. Effect of varying osmotic pressure of the dissolution medium on drug release was studied. Membrane characterization by scanning electron microscopy showed an outer dense region with less pores and an inner porous region for the prepared asymmetric membrane. In vitro release studies and statistical test for all the prepared and marketed formulation were done at P >0.05. The drug release was found to be independent of the pH, but dependent on the osmotic pressure of the dissolution medium. In vivo pharmacokinetic studies showed a level A correlation (R(2)>0.99) with 39.24 % relative bioavailability compared to immediate release tablet of ketoprofen. Excellent correlation achieved suggested that the in vivo performance of the phase transited in situ formed AMCs could be accurately predicted from their in vitro release profiles and could a means for controlled delivery of drugs with varying solubility.

No MeSH data available.


Related in: MedlinePlus

Level A in vitro in vivo correlationIn vitro in vivo correlation of in situ formed asymmetric membrane capsule delivering ketoprofen.
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Figure 0007: Level A in vitro in vivo correlationIn vitro in vivo correlation of in situ formed asymmetric membrane capsule delivering ketoprofen.

Mentions: The results of IVIVC (fig. 7) demonstrated that a good level A correlation (R2 = 0.9927) could be achieved with the fabricated in situ formed phase transited AMCs between the fraction of drug release from the dosage units and the fraction of drug absorbed. Therefore, the in vitro release profile of ketoprofen from the fabricated asymmetric membrane capsules could be used to accurately predict their in vivo performance.


In situ formed phase transited drug delivery system of ketoprofen for achieving osmotic, controlled and level a in vitro in vivo correlation.

Philip AK, Pathak K - Indian J Pharm Sci (2008)

Level A in vitro in vivo correlationIn vitro in vivo correlation of in situ formed asymmetric membrane capsule delivering ketoprofen.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3040868&req=5

Figure 0007: Level A in vitro in vivo correlationIn vitro in vivo correlation of in situ formed asymmetric membrane capsule delivering ketoprofen.
Mentions: The results of IVIVC (fig. 7) demonstrated that a good level A correlation (R2 = 0.9927) could be achieved with the fabricated in situ formed phase transited AMCs between the fraction of drug release from the dosage units and the fraction of drug absorbed. Therefore, the in vitro release profile of ketoprofen from the fabricated asymmetric membrane capsules could be used to accurately predict their in vivo performance.

Bottom Line: In vitro release studies and statistical test for all the prepared and marketed formulation were done at P >0.05.The drug release was found to be independent of the pH, but dependent on the osmotic pressure of the dissolution medium.In vivo pharmacokinetic studies showed a level A correlation (R(2)>0.99) with 39.24 % relative bioavailability compared to immediate release tablet of ketoprofen.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh-281001, India.

ABSTRACT
A dry process induced phase transited, non disintegrating, controlled release, in situ formed asymmetric membrane capsular system for poorly water soluble drug, ketoprofen, was developed and evaluated both in vitro and in vivo for osmotic and controlled release of the drug. In situ formed asymmetric membrane capsules were prepared using fabricated glass capsule holders via dry, phase inversion process. Effect of varying osmotic pressure of the dissolution medium on drug release was studied. Membrane characterization by scanning electron microscopy showed an outer dense region with less pores and an inner porous region for the prepared asymmetric membrane. In vitro release studies and statistical test for all the prepared and marketed formulation were done at P >0.05. The drug release was found to be independent of the pH, but dependent on the osmotic pressure of the dissolution medium. In vivo pharmacokinetic studies showed a level A correlation (R(2)>0.99) with 39.24 % relative bioavailability compared to immediate release tablet of ketoprofen. Excellent correlation achieved suggested that the in vivo performance of the phase transited in situ formed AMCs could be accurately predicted from their in vitro release profiles and could a means for controlled delivery of drugs with varying solubility.

No MeSH data available.


Related in: MedlinePlus