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Pharmacological evaluation of Bioactive Principle of Turnera aphrodisiaca.

Kumar S, Madaan R, Sharma A - Indian J Pharm Sci (2008)

Bottom Line: Apigenin significantly increased head dipping in hole board test.At a higher dose (about 12 fold the anxiolytic dose), apigenin showed mild sedative activity in actophotometer as it decreased activity scores.It (2, 5 or 10 mg/kg) was found to be devoid of anticonvulsant, antidepressant and antistress activity in MES-induced convulsion test, despair swim test and cold swimming endurance test, respectively.

View Article: PubMed Central - PubMed

Affiliation: S. D. College of Pharmacy, Barnala-148 101, Punjab, India.

ABSTRACT
In the present investigation, pharmacological evaluation of apigenin, a bioactive principle of Turnera aphrodisiaca Ward (Turneraceae) was carried out. Apigenin was evaluated for antianxiety activity at a dose of 2 mg/kg using well established models of anxiety, the hole board test, light/dark test and mirrored chamber test. Apigenin significantly increased head dipping in hole board test. Further, apigenin increased latency to leave light zone and the time spent in light compartment of light/dark model of anxiety. Apigenin also decreased the latency time to enter the mirrored chamber, and increased the total time spent/number of entries in the mirrored chamber with respect to control. All these observations confirmed the anxiolytic activity of apigenin. At a higher dose (about 12 fold the anxiolytic dose), apigenin showed mild sedative activity in actophotometer as it decreased activity scores. It (2, 5 or 10 mg/kg) was found to be devoid of anticonvulsant, antidepressant and antistress activity in MES-induced convulsion test, despair swim test and cold swimming endurance test, respectively. In tail immersion test for six hours, apigenin exhibited excellent dose dependent analgesic activity, which was comparable to that of morphine sulphate (5 mg/kg). Maximum activity was observed 30 min after the administration of 10 mg/kg dose of apigenin.

No MeSH data available.


Related in: MedlinePlus

Analgesic activity of apigenin in tail immersion testThe data is expressed as Mean±SEM of n=5 observations; *P<0.05 vs. control; ANOVA followed by Studentized Tukey's test. 30 min; 60 min; 120 min; 240 min; 360 min
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Figure 0005: Analgesic activity of apigenin in tail immersion testThe data is expressed as Mean±SEM of n=5 observations; *P<0.05 vs. control; ANOVA followed by Studentized Tukey's test. 30 min; 60 min; 120 min; 240 min; 360 min

Mentions: Apigenin was evaluated for analgesic activity using tail immersion test at doses of 2, 5 or 10 mg/kg, and results have been shown in fig. 5. In tail immersion test for 6 h, apigenin exhibited excellent analgesic activity, which was comparable to that of morphine sulphate (5 mg/kg). Apigenin (2, 5 or 10 mg/kg) showed dose-dependent analgesic activity. Maximum activity was observed 30 min after the administration of 10 mg/kg dose of apigenin. The activity remained significant up to the 4th h of study in a manner similar to that shown by morphine sulphate. At 6th h, analgesic activity decreased which might be due to the metabolism of apigenin.


Pharmacological evaluation of Bioactive Principle of Turnera aphrodisiaca.

Kumar S, Madaan R, Sharma A - Indian J Pharm Sci (2008)

Analgesic activity of apigenin in tail immersion testThe data is expressed as Mean±SEM of n=5 observations; *P<0.05 vs. control; ANOVA followed by Studentized Tukey's test. 30 min; 60 min; 120 min; 240 min; 360 min
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3040867&req=5

Figure 0005: Analgesic activity of apigenin in tail immersion testThe data is expressed as Mean±SEM of n=5 observations; *P<0.05 vs. control; ANOVA followed by Studentized Tukey's test. 30 min; 60 min; 120 min; 240 min; 360 min
Mentions: Apigenin was evaluated for analgesic activity using tail immersion test at doses of 2, 5 or 10 mg/kg, and results have been shown in fig. 5. In tail immersion test for 6 h, apigenin exhibited excellent analgesic activity, which was comparable to that of morphine sulphate (5 mg/kg). Apigenin (2, 5 or 10 mg/kg) showed dose-dependent analgesic activity. Maximum activity was observed 30 min after the administration of 10 mg/kg dose of apigenin. The activity remained significant up to the 4th h of study in a manner similar to that shown by morphine sulphate. At 6th h, analgesic activity decreased which might be due to the metabolism of apigenin.

Bottom Line: Apigenin significantly increased head dipping in hole board test.At a higher dose (about 12 fold the anxiolytic dose), apigenin showed mild sedative activity in actophotometer as it decreased activity scores.It (2, 5 or 10 mg/kg) was found to be devoid of anticonvulsant, antidepressant and antistress activity in MES-induced convulsion test, despair swim test and cold swimming endurance test, respectively.

View Article: PubMed Central - PubMed

Affiliation: S. D. College of Pharmacy, Barnala-148 101, Punjab, India.

ABSTRACT
In the present investigation, pharmacological evaluation of apigenin, a bioactive principle of Turnera aphrodisiaca Ward (Turneraceae) was carried out. Apigenin was evaluated for antianxiety activity at a dose of 2 mg/kg using well established models of anxiety, the hole board test, light/dark test and mirrored chamber test. Apigenin significantly increased head dipping in hole board test. Further, apigenin increased latency to leave light zone and the time spent in light compartment of light/dark model of anxiety. Apigenin also decreased the latency time to enter the mirrored chamber, and increased the total time spent/number of entries in the mirrored chamber with respect to control. All these observations confirmed the anxiolytic activity of apigenin. At a higher dose (about 12 fold the anxiolytic dose), apigenin showed mild sedative activity in actophotometer as it decreased activity scores. It (2, 5 or 10 mg/kg) was found to be devoid of anticonvulsant, antidepressant and antistress activity in MES-induced convulsion test, despair swim test and cold swimming endurance test, respectively. In tail immersion test for six hours, apigenin exhibited excellent dose dependent analgesic activity, which was comparable to that of morphine sulphate (5 mg/kg). Maximum activity was observed 30 min after the administration of 10 mg/kg dose of apigenin.

No MeSH data available.


Related in: MedlinePlus