Limits...
Synthesis and Activity Evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles.

Kumaraswamy MN, Chandrashekhar C, Shivakumar H, Prathima Mathias DA, Mahadevan KM, Vaidya VP - Indian J Pharm Sci (2008)

Bottom Line: The reaction of naphtho[2,1-b]furan-2-carbohydrazide (3) with chalcones (6a-6o) in presence of acetic acid as catalyst in dioxane produces 1-(naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles (7a-o).The structures of newly synthesized compounds have been established by elemental analysis and spectral studies.The compounds 7a-o have been evaluated for their antimicrobial activity and some selected compounds evaluated for antiinflammatory, analgesic, anthelmintic, diuretic and antipyretic activities.

View Article: PubMed Central - PubMed

Affiliation: Department of PG Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, India.

ABSTRACT
Ethyl naphtho[2,1-b]furan-2-carboxylate (2) on reaction with hydrazine hydrate in presence of acid catalyst in ethanol medium affords naphtho[2,1-b]furan-2-carbohydrazide (3). The reaction of substituted acetophenones (4a-c) with aromatic aldehydes (5a-e) produces chalcones (6a-o) via the Claisen condensation. The reaction of naphtho[2,1-b]furan-2-carbohydrazide (3) with chalcones (6a-6o) in presence of acetic acid as catalyst in dioxane produces 1-(naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles (7a-o). The structures of newly synthesized compounds have been established by elemental analysis and spectral studies. The compounds 7a-o have been evaluated for their antimicrobial activity and some selected compounds evaluated for antiinflammatory, analgesic, anthelmintic, diuretic and antipyretic activities.

No MeSH data available.


Related in: MedlinePlus

Synthetic route for the synthesis of 6a-o a- Reaction carried out in ethanol solution of sodium hydroxide at 25°
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3040863&req=5

Figure 0002: Synthetic route for the synthesis of 6a-o a- Reaction carried out in ethanol solution of sodium hydroxide at 25°

Mentions: The chalcones (6a-o) were synthesized by Claisen condensation between substituted acetophenones (4a-c) and different aromatic aldehydes27 (5a-e). The selection of substituted acetophenones and substituted aromatic aldehydes was based on presence of electron withdrawing and electron releasing groups which would assist in later studies, on structure activity relationship. The synthetic route shown in Scheme 2.


Synthesis and Activity Evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles.

Kumaraswamy MN, Chandrashekhar C, Shivakumar H, Prathima Mathias DA, Mahadevan KM, Vaidya VP - Indian J Pharm Sci (2008)

Synthetic route for the synthesis of 6a-o a- Reaction carried out in ethanol solution of sodium hydroxide at 25°
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3040863&req=5

Figure 0002: Synthetic route for the synthesis of 6a-o a- Reaction carried out in ethanol solution of sodium hydroxide at 25°
Mentions: The chalcones (6a-o) were synthesized by Claisen condensation between substituted acetophenones (4a-c) and different aromatic aldehydes27 (5a-e). The selection of substituted acetophenones and substituted aromatic aldehydes was based on presence of electron withdrawing and electron releasing groups which would assist in later studies, on structure activity relationship. The synthetic route shown in Scheme 2.

Bottom Line: The reaction of naphtho[2,1-b]furan-2-carbohydrazide (3) with chalcones (6a-6o) in presence of acetic acid as catalyst in dioxane produces 1-(naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles (7a-o).The structures of newly synthesized compounds have been established by elemental analysis and spectral studies.The compounds 7a-o have been evaluated for their antimicrobial activity and some selected compounds evaluated for antiinflammatory, analgesic, anthelmintic, diuretic and antipyretic activities.

View Article: PubMed Central - PubMed

Affiliation: Department of PG Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, India.

ABSTRACT
Ethyl naphtho[2,1-b]furan-2-carboxylate (2) on reaction with hydrazine hydrate in presence of acid catalyst in ethanol medium affords naphtho[2,1-b]furan-2-carbohydrazide (3). The reaction of substituted acetophenones (4a-c) with aromatic aldehydes (5a-e) produces chalcones (6a-o) via the Claisen condensation. The reaction of naphtho[2,1-b]furan-2-carbohydrazide (3) with chalcones (6a-6o) in presence of acetic acid as catalyst in dioxane produces 1-(naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles (7a-o). The structures of newly synthesized compounds have been established by elemental analysis and spectral studies. The compounds 7a-o have been evaluated for their antimicrobial activity and some selected compounds evaluated for antiinflammatory, analgesic, anthelmintic, diuretic and antipyretic activities.

No MeSH data available.


Related in: MedlinePlus