Activation of the central serotonergic system in response to delayed but not omitted rewards.
Bottom Line: The forebrain serotonergic system is a crucial component in the control of impulsive behaviours.By contrast, during the intermittent reward condition, in which food was given on only about one-third of the site visits, the level of dopamine was lower than that during the immediate reward condition, whereas the level of serotonin did not change significantly.This is the first direct evidence that activation of the serotonergic system occurs specifically in relation to waiting for a delayed reward.
Affiliation: Neural Computation Unit, Okinawa Institute of Science and Technology, Onna, Okinawa, Japan. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: The average baseline levels of 5-HT and DA (corrected for in vitro probe recovery) (mean ± SEM) in the DRN were 7.6 ± 2.0 pg/10 μL (n=10) and 2.3 ± 0.4 pg/10 μL (n=8), respectively. An example of the time courses of 5-HT and DA efflux sampled every 5 min, and the corresponding behavioural measures, can be seen in Fig. 4. Both 5-HT and DA levels increased during the three reward conditions compared with the rest period. The 5-HT efflux was markedly higher in the delayed reward condition than in the immediate and intermittent reward conditions (Fig. 4A). However, the DA level was markedly lower in the intermittent reward condition than in the other two conditions (Fig. 4B), resembling the temporal profile of the number of food pellets acquired (Fig. 4C).
Affiliation: Neural Computation Unit, Okinawa Institute of Science and Technology, Onna, Okinawa, Japan. email@example.com