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Activation of the central serotonergic system in response to delayed but not omitted rewards.

Miyazaki KW, Miyazaki K, Doya K - Eur. J. Neurosci. (2010)

Bottom Line: The forebrain serotonergic system is a crucial component in the control of impulsive behaviours.By contrast, during the intermittent reward condition, in which food was given on only about one-third of the site visits, the level of dopamine was lower than that during the immediate reward condition, whereas the level of serotonin did not change significantly.This is the first direct evidence that activation of the serotonergic system occurs specifically in relation to waiting for a delayed reward.

View Article: PubMed Central - PubMed

Affiliation: Neural Computation Unit, Okinawa Institute of Science and Technology, Onna, Okinawa, Japan. kmiyazaki@oist.jp

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Related in: MedlinePlus

Changes in 5-HT and DA efflux in the DRN during a task sequence. A typical example of 5-HT (A) and DA (B) efflux and behavioural measures during task sequence 2. (C) Number of food pellets acquired and (D) distance moved every 5 min during rest and task periods are plotted corresponding to 5-HT and DA efflux levels. Grey areas indicate the rest period, and dark grey areas are the rest periods used as the baseline.
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fig04: Changes in 5-HT and DA efflux in the DRN during a task sequence. A typical example of 5-HT (A) and DA (B) efflux and behavioural measures during task sequence 2. (C) Number of food pellets acquired and (D) distance moved every 5 min during rest and task periods are plotted corresponding to 5-HT and DA efflux levels. Grey areas indicate the rest period, and dark grey areas are the rest periods used as the baseline.

Mentions: The average baseline levels of 5-HT and DA (corrected for in vitro probe recovery) (mean ± SEM) in the DRN were 7.6 ± 2.0 pg/10 μL (n=10) and 2.3 ± 0.4 pg/10 μL (n=8), respectively. An example of the time courses of 5-HT and DA efflux sampled every 5 min, and the corresponding behavioural measures, can be seen in Fig. 4. Both 5-HT and DA levels increased during the three reward conditions compared with the rest period. The 5-HT efflux was markedly higher in the delayed reward condition than in the immediate and intermittent reward conditions (Fig. 4A). However, the DA level was markedly lower in the intermittent reward condition than in the other two conditions (Fig. 4B), resembling the temporal profile of the number of food pellets acquired (Fig. 4C).


Activation of the central serotonergic system in response to delayed but not omitted rewards.

Miyazaki KW, Miyazaki K, Doya K - Eur. J. Neurosci. (2010)

Changes in 5-HT and DA efflux in the DRN during a task sequence. A typical example of 5-HT (A) and DA (B) efflux and behavioural measures during task sequence 2. (C) Number of food pellets acquired and (D) distance moved every 5 min during rest and task periods are plotted corresponding to 5-HT and DA efflux levels. Grey areas indicate the rest period, and dark grey areas are the rest periods used as the baseline.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3040841&req=5

fig04: Changes in 5-HT and DA efflux in the DRN during a task sequence. A typical example of 5-HT (A) and DA (B) efflux and behavioural measures during task sequence 2. (C) Number of food pellets acquired and (D) distance moved every 5 min during rest and task periods are plotted corresponding to 5-HT and DA efflux levels. Grey areas indicate the rest period, and dark grey areas are the rest periods used as the baseline.
Mentions: The average baseline levels of 5-HT and DA (corrected for in vitro probe recovery) (mean ± SEM) in the DRN were 7.6 ± 2.0 pg/10 μL (n=10) and 2.3 ± 0.4 pg/10 μL (n=8), respectively. An example of the time courses of 5-HT and DA efflux sampled every 5 min, and the corresponding behavioural measures, can be seen in Fig. 4. Both 5-HT and DA levels increased during the three reward conditions compared with the rest period. The 5-HT efflux was markedly higher in the delayed reward condition than in the immediate and intermittent reward conditions (Fig. 4A). However, the DA level was markedly lower in the intermittent reward condition than in the other two conditions (Fig. 4B), resembling the temporal profile of the number of food pellets acquired (Fig. 4C).

Bottom Line: The forebrain serotonergic system is a crucial component in the control of impulsive behaviours.By contrast, during the intermittent reward condition, in which food was given on only about one-third of the site visits, the level of dopamine was lower than that during the immediate reward condition, whereas the level of serotonin did not change significantly.This is the first direct evidence that activation of the serotonergic system occurs specifically in relation to waiting for a delayed reward.

View Article: PubMed Central - PubMed

Affiliation: Neural Computation Unit, Okinawa Institute of Science and Technology, Onna, Okinawa, Japan. kmiyazaki@oist.jp

Show MeSH
Related in: MedlinePlus