A porcine model of acute, haematogenous, localized osteomyelitis due to Staphylococcus aureus: a pathomorphological study.
Bottom Line: Often, bone lesions resulted in trabecular osteonecrosis.The present localized model of acute haematogenous osteomyelitis revealed a pattern of development and presence of lesions similar to the situation in children.Therefore, this model should be reliably applied in studies of this disease with respect to e.g. pathophysiology and pathomorphology.
Affiliation: Department of Veterinary Disease Biology, University of Copenhagen, Frederiksberg, Denmark. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: Intra-arterial inoculation into a. brachialis dexter of pigs with S. aureus results in the development of osteomyelitis lesions in different bones supplied by the artery, whereas lesions were not observed in the control animals (Table 1). Bacteria and accompanied inflammatory reaction were localized deep in the metaphysis, next to the cartilage of the growth plate, or next to the resting zone of the growth plate, i.e. in the epiphysis (Fig. 2A–C). HO is most common in prepubertal children where the lesions typically initiate adjacent to the growth plate (1, 9). Occasionally, children with HO show acute signs of infection including fever, irritability, lethargy and local signs of inflammation (2). These clinical manifestations of paediatric osteomyelitis parallel the pattern in the present porcine model of acute stages of HO as five pigs were killed on day five or eight because of lameness of the infected leg (Table 1). Pigs killed 5 days after challenge displayed clinical signs of inflammation characterized by fever, i.e. a rectal temperature above 39.5 °C, and by oedema, redness and heat of the infected leg. Wound infections with phlegmon formation were apparent in three of the pigs (Table 1). Both pigs in the control group remained healthy throughout the trial.
Affiliation: Department of Veterinary Disease Biology, University of Copenhagen, Frederiksberg, Denmark. firstname.lastname@example.org