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Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines.

Wolff HA, Rolke D, Rave-Fränk M, Schirmer M, Eicheler W, Doerfler A, Hille A, Hess CF, Matthias C, Rödel RM, Christiansen H - Radiat Environ Biophys (2010)

Bottom Line: Of the receptors, transcript expression of CCR1, CCR2, CCR3, CCR5, CCR7, CCXR2, and CCXR3 was not detected, and CCR6, CXCR1, and CXCR4 expression was restricted to few tumor cells.Radiation caused up- and down-regulation with respect to chemokine expressions, while for chemokine receptor expressions down-regulations were prevailing.CXCL1 and CXCL12 protein expression corresponded well with the mRNA expression.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiotherapy and Radiation Oncology, Universitätsmedizin Göttingen, Göttingen, Germany.

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Chemokine receptor transcript expression relative to housekeeping genes in tumor and normal cell lines; a CCR6, b CXCR1, c CXCR4. Greater than twofold expression changes were regarded as significant and are marked by asterisks
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Fig4: Chemokine receptor transcript expression relative to housekeeping genes in tumor and normal cell lines; a CCR6, b CXCR1, c CXCR4. Greater than twofold expression changes were regarded as significant and are marked by asterisks

Mentions: Of the receptors, transcript expression of CCR1, CCR2, CCR3, CCR5, CCR7, CCXR2, CCXR3 was not detected, and CCR6 expression was restricted to BHY, KOSC2, SKN3, GR-145-I, and HK-147 tumor cells (Fig. 4a). The CXC-chemokine receptors were expressed in different cell lines; CXCR1 was expressed in HaCat, CAL33, HSC4, and XF354 (Fig. 4b), and CXCR4 was expressed in HO 1u1, FaDu, BW-225, and ZMK-1 (Fig. 4c). Radiation caused up- and down-regulation with respect to chemokine expressions, while for chemokine receptor expressions down-regulations were prevailing. Greater than twofold radiation-related changes were regarded as significant and are marked by asterisks in the respective figures.Fig. 4


Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines.

Wolff HA, Rolke D, Rave-Fränk M, Schirmer M, Eicheler W, Doerfler A, Hille A, Hess CF, Matthias C, Rödel RM, Christiansen H - Radiat Environ Biophys (2010)

Chemokine receptor transcript expression relative to housekeeping genes in tumor and normal cell lines; a CCR6, b CXCR1, c CXCR4. Greater than twofold expression changes were regarded as significant and are marked by asterisks
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3040826&req=5

Fig4: Chemokine receptor transcript expression relative to housekeeping genes in tumor and normal cell lines; a CCR6, b CXCR1, c CXCR4. Greater than twofold expression changes were regarded as significant and are marked by asterisks
Mentions: Of the receptors, transcript expression of CCR1, CCR2, CCR3, CCR5, CCR7, CCXR2, CCXR3 was not detected, and CCR6 expression was restricted to BHY, KOSC2, SKN3, GR-145-I, and HK-147 tumor cells (Fig. 4a). The CXC-chemokine receptors were expressed in different cell lines; CXCR1 was expressed in HaCat, CAL33, HSC4, and XF354 (Fig. 4b), and CXCR4 was expressed in HO 1u1, FaDu, BW-225, and ZMK-1 (Fig. 4c). Radiation caused up- and down-regulation with respect to chemokine expressions, while for chemokine receptor expressions down-regulations were prevailing. Greater than twofold radiation-related changes were regarded as significant and are marked by asterisks in the respective figures.Fig. 4

Bottom Line: Of the receptors, transcript expression of CCR1, CCR2, CCR3, CCR5, CCR7, CCXR2, and CCXR3 was not detected, and CCR6, CXCR1, and CXCR4 expression was restricted to few tumor cells.Radiation caused up- and down-regulation with respect to chemokine expressions, while for chemokine receptor expressions down-regulations were prevailing.CXCL1 and CXCL12 protein expression corresponded well with the mRNA expression.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiotherapy and Radiation Oncology, Universitätsmedizin Göttingen, Göttingen, Germany.

Show MeSH
Related in: MedlinePlus