Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines.
Bottom Line: Of the receptors, transcript expression of CCR1, CCR2, CCR3, CCR5, CCR7, CCXR2, and CCXR3 was not detected, and CCR6, CXCR1, and CXCR4 expression was restricted to few tumor cells.Radiation caused up- and down-regulation with respect to chemokine expressions, while for chemokine receptor expressions down-regulations were prevailing.CXCL1 and CXCL12 protein expression corresponded well with the mRNA expression.
Affiliation: Department of Radiotherapy and Radiation Oncology, Universitätsmedizin Göttingen, Göttingen, Germany.Show MeSH
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Mentions: Normal cells, as represented by dermal fibroblasts and HaCat-keratinocytes, showed comparable expression patterns, namely the expression of a variety of chemokines and no chemokine receptors. The transcript expression data for normal cells are integrated in Figs. 1, 2, 3, 4.Fig. 1
Affiliation: Department of Radiotherapy and Radiation Oncology, Universitätsmedizin Göttingen, Göttingen, Germany.