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PROlocalizer: integrated web service for protein subcellular localization prediction.

Laurila K, Vihinen M - Amino Acids (2010)

Bottom Line: Subcellular localization is an important protein property, which is related to function, interactions and other features.As experimental determination of the localization can be tedious, especially for large numbers of proteins, a number of prediction tools have been developed.We developed the PROlocalizer service that integrates 11 individual methods to predict altogether 12 localizations for animal proteins.

View Article: PubMed Central - PubMed

Affiliation: Department of Signal Processing, Tampere University of Technology, Tampere, Finland.

ABSTRACT
Subcellular localization is an important protein property, which is related to function, interactions and other features. As experimental determination of the localization can be tedious, especially for large numbers of proteins, a number of prediction tools have been developed. We developed the PROlocalizer service that integrates 11 individual methods to predict altogether 12 localizations for animal proteins. The method allows the submission of a number of proteins and mutations and generates a detailed informative document of the prediction and obtained results. PROlocalizer is available at http://bioinf.uta.fi/PROlocalizer/ .

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PROlocalizer home page and example of a prediction. Top PROlocalizer home page, Bottom example of the output for a prediction. Only part of the report is shown
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Fig2: PROlocalizer home page and example of a prediction. Top PROlocalizer home page, Bottom example of the output for a prediction. Only part of the report is shown

Mentions: PROlocalizer has a user-friendly graphic interface (Fig. 2). The user needs to provide only protein sequence(s) in fasta format. Submission can be done via a file or pasting the information to the submission form. PROlocalizer can also efficiently predict the subcellular localization for relatively large protein datasets. Furthermore, effects of one or more missense mutations per protein can be predicted by PROlocalizer just by providing the wild type sequence and the original and mutated residues along with position information.Fig. 2


PROlocalizer: integrated web service for protein subcellular localization prediction.

Laurila K, Vihinen M - Amino Acids (2010)

PROlocalizer home page and example of a prediction. Top PROlocalizer home page, Bottom example of the output for a prediction. Only part of the report is shown
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3040813&req=5

Fig2: PROlocalizer home page and example of a prediction. Top PROlocalizer home page, Bottom example of the output for a prediction. Only part of the report is shown
Mentions: PROlocalizer has a user-friendly graphic interface (Fig. 2). The user needs to provide only protein sequence(s) in fasta format. Submission can be done via a file or pasting the information to the submission form. PROlocalizer can also efficiently predict the subcellular localization for relatively large protein datasets. Furthermore, effects of one or more missense mutations per protein can be predicted by PROlocalizer just by providing the wild type sequence and the original and mutated residues along with position information.Fig. 2

Bottom Line: Subcellular localization is an important protein property, which is related to function, interactions and other features.As experimental determination of the localization can be tedious, especially for large numbers of proteins, a number of prediction tools have been developed.We developed the PROlocalizer service that integrates 11 individual methods to predict altogether 12 localizations for animal proteins.

View Article: PubMed Central - PubMed

Affiliation: Department of Signal Processing, Tampere University of Technology, Tampere, Finland.

ABSTRACT
Subcellular localization is an important protein property, which is related to function, interactions and other features. As experimental determination of the localization can be tedious, especially for large numbers of proteins, a number of prediction tools have been developed. We developed the PROlocalizer service that integrates 11 individual methods to predict altogether 12 localizations for animal proteins. The method allows the submission of a number of proteins and mutations and generates a detailed informative document of the prediction and obtained results. PROlocalizer is available at http://bioinf.uta.fi/PROlocalizer/ .

Show MeSH