Limits...
Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors.

Soto-De Leon S, Camargo M, Sanchez R, Munoz M, Perez-Prados A, Purroy A, Patarroyo ME, Patarroyo MA - PLoS ONE (2011)

Bottom Line: The negative binomial distribution model used in this study showed differences between the observed and expected values within some risk factor categories analyzed.Data analysis according to a negative binomial regression showed an increase in the risk of acquiring more HPV types in women who were of indigenous ethnicity (+37.8%), while this risk decreased in women who had given birth more than 4 times (-31.1%), or were of mestizo (-24.6%) or black (-40.9%) ethnicity.Taking into account that this study showed a higher HPV coinfection rate in the indigenous ethnicity, the role of underlying factors should be assessed in detail in future studies.

View Article: PubMed Central - PubMed

Affiliation: Molecular Biology Department, Fundacion Instituto de Inmunologia de Colombia, Bogota, Cundinamarca, Colombia.

ABSTRACT

Background: Infection with multiple types of human papillomavirus (HPV) is one of the main risk factors associated with the development of cervical lesions. In this study, cervical samples collected from 1,810 women with diverse sociocultural backgrounds, who attended to their cervical screening program in different geographical regions of Colombia, were examined for the presence of cervical lesions and HPV by Papanicolau testing and DNA PCR detection, respectively.

Principal findings: The negative binomial distribution model used in this study showed differences between the observed and expected values within some risk factor categories analyzed. Particularly in the case of single infection and coinfection with more than 4 HPV types, observed frequencies were smaller than expected, while the number of women infected with 2 to 4 viral types were higher than expected. Data analysis according to a negative binomial regression showed an increase in the risk of acquiring more HPV types in women who were of indigenous ethnicity (+37.8%), while this risk decreased in women who had given birth more than 4 times (-31.1%), or were of mestizo (-24.6%) or black (-40.9%) ethnicity.

Conclusions: According to a theoretical probability distribution, the observed number of women having either a single infection or more than 4 viral types was smaller than expected, while for those infected with 2-4 HPV types it was larger than expected. Taking into account that this study showed a higher HPV coinfection rate in the indigenous ethnicity, the role of underlying factors should be assessed in detail in future studies.

Show MeSH

Related in: MedlinePlus

Geographic localization of the five populations included in this study (modified from [49]).
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3040737&req=5

pone-0014705-g001: Geographic localization of the five populations included in this study (modified from [49]).

Mentions: The present study involved 5 regions with different socio-cultural and geographical characteristics, whose CC mortality rates ranged between 3.12 and 5.67/100,000 inhabitants. These regions are: Bogota, the country's capital, with an urban population, which have access to adequate health facilities. Leticia, localized in the department of Amazonas, which is a tropical region inside the colombian jungle characterized by its proximity to Peru and Brazil, favored by high migration rates and an important ethnical diversity with a predominant indigenous background. Chaparral, located in the department of Tolima, is mainly constituted by mestizos with a sedentary life style. Another region participating in this study was Girardot, located in the department of Cundinamarca which due to its favorable weather and great proximity to Bogota has become a preferred touristic destination. It is worth noting that most of the afore-mentioned regions display a predominantly mestizo population, whereas the fifth region considered in this study, Tumaco, which is a Pacific coastal region, represents most of the black population enrolled for this work (Figure 1).


Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors.

Soto-De Leon S, Camargo M, Sanchez R, Munoz M, Perez-Prados A, Purroy A, Patarroyo ME, Patarroyo MA - PLoS ONE (2011)

Geographic localization of the five populations included in this study (modified from [49]).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3040737&req=5

pone-0014705-g001: Geographic localization of the five populations included in this study (modified from [49]).
Mentions: The present study involved 5 regions with different socio-cultural and geographical characteristics, whose CC mortality rates ranged between 3.12 and 5.67/100,000 inhabitants. These regions are: Bogota, the country's capital, with an urban population, which have access to adequate health facilities. Leticia, localized in the department of Amazonas, which is a tropical region inside the colombian jungle characterized by its proximity to Peru and Brazil, favored by high migration rates and an important ethnical diversity with a predominant indigenous background. Chaparral, located in the department of Tolima, is mainly constituted by mestizos with a sedentary life style. Another region participating in this study was Girardot, located in the department of Cundinamarca which due to its favorable weather and great proximity to Bogota has become a preferred touristic destination. It is worth noting that most of the afore-mentioned regions display a predominantly mestizo population, whereas the fifth region considered in this study, Tumaco, which is a Pacific coastal region, represents most of the black population enrolled for this work (Figure 1).

Bottom Line: The negative binomial distribution model used in this study showed differences between the observed and expected values within some risk factor categories analyzed.Data analysis according to a negative binomial regression showed an increase in the risk of acquiring more HPV types in women who were of indigenous ethnicity (+37.8%), while this risk decreased in women who had given birth more than 4 times (-31.1%), or were of mestizo (-24.6%) or black (-40.9%) ethnicity.Taking into account that this study showed a higher HPV coinfection rate in the indigenous ethnicity, the role of underlying factors should be assessed in detail in future studies.

View Article: PubMed Central - PubMed

Affiliation: Molecular Biology Department, Fundacion Instituto de Inmunologia de Colombia, Bogota, Cundinamarca, Colombia.

ABSTRACT

Background: Infection with multiple types of human papillomavirus (HPV) is one of the main risk factors associated with the development of cervical lesions. In this study, cervical samples collected from 1,810 women with diverse sociocultural backgrounds, who attended to their cervical screening program in different geographical regions of Colombia, were examined for the presence of cervical lesions and HPV by Papanicolau testing and DNA PCR detection, respectively.

Principal findings: The negative binomial distribution model used in this study showed differences between the observed and expected values within some risk factor categories analyzed. Particularly in the case of single infection and coinfection with more than 4 HPV types, observed frequencies were smaller than expected, while the number of women infected with 2 to 4 viral types were higher than expected. Data analysis according to a negative binomial regression showed an increase in the risk of acquiring more HPV types in women who were of indigenous ethnicity (+37.8%), while this risk decreased in women who had given birth more than 4 times (-31.1%), or were of mestizo (-24.6%) or black (-40.9%) ethnicity.

Conclusions: According to a theoretical probability distribution, the observed number of women having either a single infection or more than 4 viral types was smaller than expected, while for those infected with 2-4 HPV types it was larger than expected. Taking into account that this study showed a higher HPV coinfection rate in the indigenous ethnicity, the role of underlying factors should be assessed in detail in future studies.

Show MeSH
Related in: MedlinePlus