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Incidence of hepatitis-C among HIV infected men who have sex with men (MSM) attending a sexual health service: a cohort study.

Gamage DG, Read TR, Bradshaw CS, Hocking JS, Howley K, Chen MY, Fairley CK - BMC Infect. Dis. (2011)

Bottom Line: The overall incidence of HCV among HIV-infected MSM was 0.9/100 PY (95% CI 0.6-1.2).The incidence among HIV-infected IDU was 4.7/100 PY (95% CI 2.7-7.5) while the incidence among HIV-infected non-IDU was 0.6/100 PY (95% CI 0.4-0.8) (hazard ratio of 8.7 and 95% CI 4.6-16.6, P < 0.001).The majority (78%) were tested for HCV because they developed abnormal liver transaminases (n = 31) or hepatitis symptoms (n = 2), while others (n = 7) were identified through routine HCV testing.A considerable proportion of HIV-positive MSM who did not inject drugs contracted HCV, presumably via sexual transmission and the main trigger for investigation was abnormal liver transaminases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia.

ABSTRACT

Background: We aimed to determine the incidence of Hepatitis C (HCV) infection among HIV-infected men who have sex with men (MSM) attending a Sexual Health Centre.

Methods: A retrospective cohort study was carried out among HIV-infected MSM seen at least once between February 2002 and March 2010. The analysis was restricted to MSM who had had a negative HCV antibody test at least 6 months after their diagnosis for HIV. Duration of follow up was taken from the date of HIV diagnosis to the first positive or last negative HCV antibody test.

Results: During the time 1445 HIV-infected men attended the clinic of whom 1065 (74%) were MSM. Of these, 869 (82%) were tested for HCV at any time after HIV diagnosis. Of these 869, 69% (620) tested HCV negative at least 6 months after their HIV diagnosis. These 620 men had a mean age of 34 years (range 17-72) at HIV diagnosis and a total of 4,359 person years (PY) of follow up. There were 40 incident cases of HCV, of which 16 were in injecting drug users (IDU) and 24 in non-IDU. The overall incidence of HCV among HIV-infected MSM was 0.9/100 PY (95% CI 0.6-1.2). The incidence among HIV-infected IDU was 4.7/100 PY (95% CI 2.7-7.5) while the incidence among HIV-infected non-IDU was 0.6/100 PY (95% CI 0.4-0.8) (hazard ratio of 8.7 and 95% CI 4.6-16.6, P < 0.001).The majority (78%) were tested for HCV because they developed abnormal liver transaminases (n = 31) or hepatitis symptoms (n = 2), while others (n = 7) were identified through routine HCV testing.

Conclusion: A considerable proportion of HIV-positive MSM who did not inject drugs contracted HCV, presumably via sexual transmission and the main trigger for investigation was abnormal liver transaminases.

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Cohort of HIV positive MSM in identifying hepatitis C incident cases.
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Figure 1: Cohort of HIV positive MSM in identifying hepatitis C incident cases.

Mentions: There were 1445 HIV infected males seen at least once at MSHC during the eight year period. Of these 1065 (74%) were MSM and of these 869 (82%) were tested for HCV at any time after HIV diagnosis. Of these 869, we excluded 180 HCV-negatives because their last HCV test was less than 6 months after their first HIV positive test (figure 1). We also excluded 69 HCV positive cases (41 non-IDU and 28 IDU) because they had HCV at the time of or before their HIV diagnosis (n = 47) or they did not have a negative HCV test before their first positive HCV test (n = 22). Therefore 620 MSM with a HCV antibody negative test more than 6 months after their HIV diagnosis were included in this cohort.


Incidence of hepatitis-C among HIV infected men who have sex with men (MSM) attending a sexual health service: a cohort study.

Gamage DG, Read TR, Bradshaw CS, Hocking JS, Howley K, Chen MY, Fairley CK - BMC Infect. Dis. (2011)

Cohort of HIV positive MSM in identifying hepatitis C incident cases.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3040713&req=5

Figure 1: Cohort of HIV positive MSM in identifying hepatitis C incident cases.
Mentions: There were 1445 HIV infected males seen at least once at MSHC during the eight year period. Of these 1065 (74%) were MSM and of these 869 (82%) were tested for HCV at any time after HIV diagnosis. Of these 869, we excluded 180 HCV-negatives because their last HCV test was less than 6 months after their first HIV positive test (figure 1). We also excluded 69 HCV positive cases (41 non-IDU and 28 IDU) because they had HCV at the time of or before their HIV diagnosis (n = 47) or they did not have a negative HCV test before their first positive HCV test (n = 22). Therefore 620 MSM with a HCV antibody negative test more than 6 months after their HIV diagnosis were included in this cohort.

Bottom Line: The overall incidence of HCV among HIV-infected MSM was 0.9/100 PY (95% CI 0.6-1.2).The incidence among HIV-infected IDU was 4.7/100 PY (95% CI 2.7-7.5) while the incidence among HIV-infected non-IDU was 0.6/100 PY (95% CI 0.4-0.8) (hazard ratio of 8.7 and 95% CI 4.6-16.6, P < 0.001).The majority (78%) were tested for HCV because they developed abnormal liver transaminases (n = 31) or hepatitis symptoms (n = 2), while others (n = 7) were identified through routine HCV testing.A considerable proportion of HIV-positive MSM who did not inject drugs contracted HCV, presumably via sexual transmission and the main trigger for investigation was abnormal liver transaminases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia.

ABSTRACT

Background: We aimed to determine the incidence of Hepatitis C (HCV) infection among HIV-infected men who have sex with men (MSM) attending a Sexual Health Centre.

Methods: A retrospective cohort study was carried out among HIV-infected MSM seen at least once between February 2002 and March 2010. The analysis was restricted to MSM who had had a negative HCV antibody test at least 6 months after their diagnosis for HIV. Duration of follow up was taken from the date of HIV diagnosis to the first positive or last negative HCV antibody test.

Results: During the time 1445 HIV-infected men attended the clinic of whom 1065 (74%) were MSM. Of these, 869 (82%) were tested for HCV at any time after HIV diagnosis. Of these 869, 69% (620) tested HCV negative at least 6 months after their HIV diagnosis. These 620 men had a mean age of 34 years (range 17-72) at HIV diagnosis and a total of 4,359 person years (PY) of follow up. There were 40 incident cases of HCV, of which 16 were in injecting drug users (IDU) and 24 in non-IDU. The overall incidence of HCV among HIV-infected MSM was 0.9/100 PY (95% CI 0.6-1.2). The incidence among HIV-infected IDU was 4.7/100 PY (95% CI 2.7-7.5) while the incidence among HIV-infected non-IDU was 0.6/100 PY (95% CI 0.4-0.8) (hazard ratio of 8.7 and 95% CI 4.6-16.6, P < 0.001).The majority (78%) were tested for HCV because they developed abnormal liver transaminases (n = 31) or hepatitis symptoms (n = 2), while others (n = 7) were identified through routine HCV testing.

Conclusion: A considerable proportion of HIV-positive MSM who did not inject drugs contracted HCV, presumably via sexual transmission and the main trigger for investigation was abnormal liver transaminases.

Show MeSH
Related in: MedlinePlus