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The value of serum biomarkers (Bc1, Bc2, Bc3) in the diagnosis of early breast cancer.

Atahan K, Küpeli H, Gür S, Yiğitbaşı T, Baskın Y, Yiğit S, Deniz M, Cökmez A, Tarcan E - Int J Med Sci (2011)

Bottom Line: Bc1 was statistically significant in the malignant disease group compared to control group as well as in the benign disease group compared to control group.Bc3 was found upregulated in all malignant cases; however, it was not statistically significant compared to the benign disease group or the control group.Additional confirmation in larger and similarly-designed prospective studies is needed to consider of the efficacy of Bc1 and Bc2 in early diagnosis of the BC.

View Article: PubMed Central - PubMed

Affiliation: İzmir Atatürk Training and Research Hospital 1st Surgical Clinic, Turkey. kemalatahan@yahoo.com.tr

ABSTRACT

Background: Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF) is an approach to biomarker discovery that combines chromatography and mass spectrometry. We aimed to consider the efficacy of Bc1, Bc2, and Bc3 serum biomarkers on early detection of breast cancer (BC) in this study.

Study design: In this prospective study, 91 patients who were admitted to our hospital between January 2007 and July 2008 were included. Serum samples from 91 women were stored at -80 °C until use. The cancer group included 27 cases of BC. The benign breast disease group included 24 women with benign breast diseases and control group 37 age-matched apparently healthy women. The data obtained for these three groups of patients was worked out for each serum biomarker (Bc1, Bc2, and Bc3) by using SELDI-TOF individually and compared with each other separately and evaluated statistically.

Results: Bc2 possesses the highest individual diagnostic power. Bc2 was statistically significant in comparison between the malignant disease group, control group and benign disease group. Bc1 was statistically significant in the malignant disease group compared to control group as well as in the benign disease group compared to control group. Thus Bc1, rather than showing malignant progression, it shows tumoral progression or inflammatory process. Bc3 was found upregulated in all malignant cases; however, it was not statistically significant compared to the benign disease group or the control group.

Conclusions: It has been shown that Bc2 profiles might be useful in clinical practice to improve BC diagnosis. However none of the proteomics reach reasonable AUC values for the discrimination of the BC. Additional confirmation in larger and similarly-designed prospective studies is needed to consider of the efficacy of Bc1 and Bc2 in early diagnosis of the BC.

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Related in: MedlinePlus

Comparison of subjects in the malignant and benign groups for Bc2
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Figure 1: Comparison of subjects in the malignant and benign groups for Bc2

Mentions: Bc2 was found significantly higher in both the comparison of malignant and benign patients (Figure 1) and malignant patients versus patients in the control group (Figure 2) (p=0.002 and p=0.003, respectively) (Table 2). The AUC values did not reach at 0.70 for the Bc2 in the groups. Bc1 was statistically significantly higher in the comparison of malignant patients to those in the control groups, as well as in the comparison of benign patients and those in the control group (p=0.006 and p=0.015, respectively). The AUC values were below the 0.70 for Bc1 in all groups. Although Bc3 was high in all malignant patients, the comparison of the benign and control groups did not yield a statistically significant difference (p=0.098 and p=0.134, respectively).


The value of serum biomarkers (Bc1, Bc2, Bc3) in the diagnosis of early breast cancer.

Atahan K, Küpeli H, Gür S, Yiğitbaşı T, Baskın Y, Yiğit S, Deniz M, Cökmez A, Tarcan E - Int J Med Sci (2011)

Comparison of subjects in the malignant and benign groups for Bc2
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3039230&req=5

Figure 1: Comparison of subjects in the malignant and benign groups for Bc2
Mentions: Bc2 was found significantly higher in both the comparison of malignant and benign patients (Figure 1) and malignant patients versus patients in the control group (Figure 2) (p=0.002 and p=0.003, respectively) (Table 2). The AUC values did not reach at 0.70 for the Bc2 in the groups. Bc1 was statistically significantly higher in the comparison of malignant patients to those in the control groups, as well as in the comparison of benign patients and those in the control group (p=0.006 and p=0.015, respectively). The AUC values were below the 0.70 for Bc1 in all groups. Although Bc3 was high in all malignant patients, the comparison of the benign and control groups did not yield a statistically significant difference (p=0.098 and p=0.134, respectively).

Bottom Line: Bc1 was statistically significant in the malignant disease group compared to control group as well as in the benign disease group compared to control group.Bc3 was found upregulated in all malignant cases; however, it was not statistically significant compared to the benign disease group or the control group.Additional confirmation in larger and similarly-designed prospective studies is needed to consider of the efficacy of Bc1 and Bc2 in early diagnosis of the BC.

View Article: PubMed Central - PubMed

Affiliation: İzmir Atatürk Training and Research Hospital 1st Surgical Clinic, Turkey. kemalatahan@yahoo.com.tr

ABSTRACT

Background: Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF) is an approach to biomarker discovery that combines chromatography and mass spectrometry. We aimed to consider the efficacy of Bc1, Bc2, and Bc3 serum biomarkers on early detection of breast cancer (BC) in this study.

Study design: In this prospective study, 91 patients who were admitted to our hospital between January 2007 and July 2008 were included. Serum samples from 91 women were stored at -80 °C until use. The cancer group included 27 cases of BC. The benign breast disease group included 24 women with benign breast diseases and control group 37 age-matched apparently healthy women. The data obtained for these three groups of patients was worked out for each serum biomarker (Bc1, Bc2, and Bc3) by using SELDI-TOF individually and compared with each other separately and evaluated statistically.

Results: Bc2 possesses the highest individual diagnostic power. Bc2 was statistically significant in comparison between the malignant disease group, control group and benign disease group. Bc1 was statistically significant in the malignant disease group compared to control group as well as in the benign disease group compared to control group. Thus Bc1, rather than showing malignant progression, it shows tumoral progression or inflammatory process. Bc3 was found upregulated in all malignant cases; however, it was not statistically significant compared to the benign disease group or the control group.

Conclusions: It has been shown that Bc2 profiles might be useful in clinical practice to improve BC diagnosis. However none of the proteomics reach reasonable AUC values for the discrimination of the BC. Additional confirmation in larger and similarly-designed prospective studies is needed to consider of the efficacy of Bc1 and Bc2 in early diagnosis of the BC.

Show MeSH
Related in: MedlinePlus