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Gait and cognition in older adults: Insights from the Bronx and Kerala.

Ambrose AF, Noone ML, Pradeep VG, Johnson B, Salam KA, Verghese J - Ann Indian Acad Neurol (2010)

Bottom Line: Literature review of gait and cognition studies conducted in Bronx County, USA as well as preliminary results from the Kerala-Einstein study (Kozhikode city, Kerala).A strong association between gait and cognition is seen in seniors in USA as well as Kerala.A better understanding of the relationship between gait and cognition may help improve current diagnostic and therapeutic approaches globally.

View Article: PubMed Central - PubMed

Affiliation: Department of Rehabilitation Medicine, Mt Sinai Medical Center, New York, NY, USA.

ABSTRACT

Background: Recent reports indicate that gait dysfunction can occur early in the course of cognitive decline suggesting that motor and cognitive functions in older adults may share common underlying brain substrates, pathological processes, and risk factors.

Objective: This study was designed to report the association between gait and cognition in older adults in USA and the southern Indian state of Kerala.

Materials and methods: Literature review of gait and cognition studies conducted in Bronx County, USA as well as preliminary results from the Kerala-Einstein study (Kozhikode city, Kerala).

Results: Review of published studies based in the Bronx shows that both clinical and quantitative gait dysfunction are common in older adults with cognitive impairment. Furthermore, clinical and quantitative gait dysfunction in cognitively normal older adults was a strong predictor of future cognitive decline and dementia. Our preliminary study in Kozhikode city shows that timed gait is slower in older adults diagnosed with dementia and mild cognitive impairment syndrome compared to healthy older controls.

Conclusions: A strong association between gait and cognition is seen in seniors in USA as well as Kerala. A better understanding of the relationship between gait and cognition may help improve current diagnostic and therapeutic approaches globally.

No MeSH data available.


Related in: MedlinePlus

Boxplots depicting walking time over the 10-foot course at usual pace in subjects with dementia, MCI, and normal controls in the Kerala-Einstein study. Higher times indicate worse performance. The line in the middle of the box represents the median value. The ends of the box represent the 25th and 75th quartile values. The bars show the range of scores and black dots are outliers.
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Figure 0002: Boxplots depicting walking time over the 10-foot course at usual pace in subjects with dementia, MCI, and normal controls in the Kerala-Einstein study. Higher times indicate worse performance. The line in the middle of the box represents the median value. The ends of the box represent the 25th and 75th quartile values. The bars show the range of scores and black dots are outliers.

Mentions: Subjects were timed with a stopwatch while walking a 10-foot course at their usual pace as well as at a fast pace. Six out of the 52 subjects with dementia and two out of the normal controls were unable to walk, and were not included in this analysis. An additional subject with dementia walked the course at usual pace, but not at fast pace. The remaining 46 subjects with dementia (median 15 s, P < 0.001) and 19 MCI subjects (median, 16 s, P < 0.001) walked slower at their usual pace over the 10-foot course compared to the 144 normal controls (median, 11 s). A similar pattern was seen comparing the 45 ambulatory subjects with dementia (median, 12 s, P < 0.001) and the 19 MCI subjects (median 11 s, P < 0.001) to the 144 controls (median, 8 s) when they walked at a fast pace over the same distance. Figures 2 and 3 present the time to walk 10 feet (longer times worse) at usual pace as well as at fast pace by diagnostic groups.


Gait and cognition in older adults: Insights from the Bronx and Kerala.

Ambrose AF, Noone ML, Pradeep VG, Johnson B, Salam KA, Verghese J - Ann Indian Acad Neurol (2010)

Boxplots depicting walking time over the 10-foot course at usual pace in subjects with dementia, MCI, and normal controls in the Kerala-Einstein study. Higher times indicate worse performance. The line in the middle of the box represents the median value. The ends of the box represent the 25th and 75th quartile values. The bars show the range of scores and black dots are outliers.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3039166&req=5

Figure 0002: Boxplots depicting walking time over the 10-foot course at usual pace in subjects with dementia, MCI, and normal controls in the Kerala-Einstein study. Higher times indicate worse performance. The line in the middle of the box represents the median value. The ends of the box represent the 25th and 75th quartile values. The bars show the range of scores and black dots are outliers.
Mentions: Subjects were timed with a stopwatch while walking a 10-foot course at their usual pace as well as at a fast pace. Six out of the 52 subjects with dementia and two out of the normal controls were unable to walk, and were not included in this analysis. An additional subject with dementia walked the course at usual pace, but not at fast pace. The remaining 46 subjects with dementia (median 15 s, P < 0.001) and 19 MCI subjects (median, 16 s, P < 0.001) walked slower at their usual pace over the 10-foot course compared to the 144 normal controls (median, 11 s). A similar pattern was seen comparing the 45 ambulatory subjects with dementia (median, 12 s, P < 0.001) and the 19 MCI subjects (median 11 s, P < 0.001) to the 144 controls (median, 8 s) when they walked at a fast pace over the same distance. Figures 2 and 3 present the time to walk 10 feet (longer times worse) at usual pace as well as at fast pace by diagnostic groups.

Bottom Line: Literature review of gait and cognition studies conducted in Bronx County, USA as well as preliminary results from the Kerala-Einstein study (Kozhikode city, Kerala).A strong association between gait and cognition is seen in seniors in USA as well as Kerala.A better understanding of the relationship between gait and cognition may help improve current diagnostic and therapeutic approaches globally.

View Article: PubMed Central - PubMed

Affiliation: Department of Rehabilitation Medicine, Mt Sinai Medical Center, New York, NY, USA.

ABSTRACT

Background: Recent reports indicate that gait dysfunction can occur early in the course of cognitive decline suggesting that motor and cognitive functions in older adults may share common underlying brain substrates, pathological processes, and risk factors.

Objective: This study was designed to report the association between gait and cognition in older adults in USA and the southern Indian state of Kerala.

Materials and methods: Literature review of gait and cognition studies conducted in Bronx County, USA as well as preliminary results from the Kerala-Einstein study (Kozhikode city, Kerala).

Results: Review of published studies based in the Bronx shows that both clinical and quantitative gait dysfunction are common in older adults with cognitive impairment. Furthermore, clinical and quantitative gait dysfunction in cognitively normal older adults was a strong predictor of future cognitive decline and dementia. Our preliminary study in Kozhikode city shows that timed gait is slower in older adults diagnosed with dementia and mild cognitive impairment syndrome compared to healthy older controls.

Conclusions: A strong association between gait and cognition is seen in seniors in USA as well as Kerala. A better understanding of the relationship between gait and cognition may help improve current diagnostic and therapeutic approaches globally.

No MeSH data available.


Related in: MedlinePlus