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Pyramidal cells in prefrontal cortex of primates: marked differences in neuronal structure among species.

Elston GN, Benavides-Piccione R, Elston A, Manger PR, Defelipe J - Front Neuroanat (2011)

Bottom Line: Here we undertook a survey of pyramidal cells in the dorsolateral, medial, and orbital gPFC of cercopithecid primates.We found marked heterogeneity in pyramidal cell structure within and between these regions.Moreover, trends for gradients in neuronal complexity varied among species.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cognitive Neuroscience Sunshine Coast, QLD, Australia.

ABSTRACT
The most ubiquitous neuron in the cerebral cortex, the pyramidal cell, is characterized by markedly different dendritic structure among different cortical areas. The complex pyramidal cell phenotype in granular prefrontal cortex (gPFC) of higher primates endows specific biophysical properties and patterns of connectivity, which differ from those in other cortical regions. However, within the gPFC, data have been sampled from only a select few cortical areas. The gPFC of species such as human and macaque monkey includes more than 10 cortical areas. It remains unknown as to what degree pyramidal cell structure may vary among these cortical areas. Here we undertook a survey of pyramidal cells in the dorsolateral, medial, and orbital gPFC of cercopithecid primates. We found marked heterogeneity in pyramidal cell structure within and between these regions. Moreover, trends for gradients in neuronal complexity varied among species. As the structure of neurons determines their computational abilities, memory storage capacity and connectivity, we propose that these specializations in the pyramidal cell phenotype are an important determinant of species-specific executive cortical functions in primates.

No MeSH data available.


Frequency histograms and plots of the (A) size, (B) branching patterns, (C) spine density of the basal dendritic trees, and (D) cell body size, of layer III pyramidal neurons sampled in granular prefrontal cortex of the macaque monkey (M1 and M2), vervet monkey (VM1 and VM2) and baboon (B1 and B2). Error bars =  standard errors.
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Figure 5: Frequency histograms and plots of the (A) size, (B) branching patterns, (C) spine density of the basal dendritic trees, and (D) cell body size, of layer III pyramidal neurons sampled in granular prefrontal cortex of the macaque monkey (M1 and M2), vervet monkey (VM1 and VM2) and baboon (B1 and B2). Error bars =  standard errors.

Mentions: Qualitative observation revealed variation in the size of the dendritic trees of pyramidal cells among prefrontal areas 9d, 10, 12vl, 13, and 46vr in both MF1 and MF2 (Figure 5A; Table 1). Statistical analysis (one-way ANOVAs) revealed these differences to be significant (p < 0.05) in both MF1 (F(4) = 8.92) and MF2 (F(4) = 15.33). Post hoc Scheffe tests revealed 3 of 10 possible between-area comparisons to be significantly different in MF1 and 4 of 10 in MF2 (Table 2).


Pyramidal cells in prefrontal cortex of primates: marked differences in neuronal structure among species.

Elston GN, Benavides-Piccione R, Elston A, Manger PR, Defelipe J - Front Neuroanat (2011)

Frequency histograms and plots of the (A) size, (B) branching patterns, (C) spine density of the basal dendritic trees, and (D) cell body size, of layer III pyramidal neurons sampled in granular prefrontal cortex of the macaque monkey (M1 and M2), vervet monkey (VM1 and VM2) and baboon (B1 and B2). Error bars =  standard errors.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3039119&req=5

Figure 5: Frequency histograms and plots of the (A) size, (B) branching patterns, (C) spine density of the basal dendritic trees, and (D) cell body size, of layer III pyramidal neurons sampled in granular prefrontal cortex of the macaque monkey (M1 and M2), vervet monkey (VM1 and VM2) and baboon (B1 and B2). Error bars =  standard errors.
Mentions: Qualitative observation revealed variation in the size of the dendritic trees of pyramidal cells among prefrontal areas 9d, 10, 12vl, 13, and 46vr in both MF1 and MF2 (Figure 5A; Table 1). Statistical analysis (one-way ANOVAs) revealed these differences to be significant (p < 0.05) in both MF1 (F(4) = 8.92) and MF2 (F(4) = 15.33). Post hoc Scheffe tests revealed 3 of 10 possible between-area comparisons to be significantly different in MF1 and 4 of 10 in MF2 (Table 2).

Bottom Line: Here we undertook a survey of pyramidal cells in the dorsolateral, medial, and orbital gPFC of cercopithecid primates.We found marked heterogeneity in pyramidal cell structure within and between these regions.Moreover, trends for gradients in neuronal complexity varied among species.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cognitive Neuroscience Sunshine Coast, QLD, Australia.

ABSTRACT
The most ubiquitous neuron in the cerebral cortex, the pyramidal cell, is characterized by markedly different dendritic structure among different cortical areas. The complex pyramidal cell phenotype in granular prefrontal cortex (gPFC) of higher primates endows specific biophysical properties and patterns of connectivity, which differ from those in other cortical regions. However, within the gPFC, data have been sampled from only a select few cortical areas. The gPFC of species such as human and macaque monkey includes more than 10 cortical areas. It remains unknown as to what degree pyramidal cell structure may vary among these cortical areas. Here we undertook a survey of pyramidal cells in the dorsolateral, medial, and orbital gPFC of cercopithecid primates. We found marked heterogeneity in pyramidal cell structure within and between these regions. Moreover, trends for gradients in neuronal complexity varied among species. As the structure of neurons determines their computational abilities, memory storage capacity and connectivity, we propose that these specializations in the pyramidal cell phenotype are an important determinant of species-specific executive cortical functions in primates.

No MeSH data available.