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A Young Man with Anti-NMDAR Encephalitis following Guillain-Barré Syndrome.

Tojo K, Nitta K, Ishii W, Sekijima Y, Morita H, Takahashi Y, Tanaka K, Ikeda S - Case Rep Neurol (2011)

Bottom Line: Anti-N-methyl-D-aspartate receptor (NMDAR) antibodies in serum and cerebrospinal fluid were positive on the 92nd hospital day.Anti-NMDAR encephalitis usually affects young females but a small number of male cases with this disease have been reported.Our male patient was unique in having GBS, a post-infectious autoimmune disease, as a preceding disease, suggesting that anti-NMDAR encephalitis itself is caused by a parainfectious autoimmune mechanism.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.

ABSTRACT
A 19-year-old man developed rapidly progressive muscle weakness and dysesthesia in the extremities, and dyspnea after a flu-like episode. Nerve conduction studies showed reduced motor nerve conduction velocities with conduction block, and sensory nerve action potentials could not be evoked. The patient was diagnosed as having Guillain-Barré syndrome (GBS), and was treated with 2 cycles of intravenous immunoglobulin (IVIg) therapy and was assisted by mechanical ventilation. During the recovery course of the illness, he experienced several attacks of psychomotor agitation from the 37th hospital day, and generalized tonic convulsive seizures suddenly developed on the 42nd hospital day. Brain MRI showed high-intensity lesions in the bilateral thalamus and medial temporal lobes. The convulsions were controlled by continuous thiopental infusion (until the 50th hospital day) and mechanical ventilation (until the 84th hospital day). Intravenous methylprednisolone pulse therapy (1,000 mg/day) for 3 days followed by dexamethasone (16 mg/day) was added. After relief of convulsive seizures, prominent orolingual dyskinesia appeared, and on MRI marked atrophy of the bilateral medial temporal lobes was seen. Anti-N-methyl-D-aspartate receptor (NMDAR) antibodies in serum and cerebrospinal fluid were positive on the 92nd hospital day. Anti-NMDAR encephalitis usually affects young females but a small number of male cases with this disease have been reported. Our male patient was unique in having GBS, a post-infectious autoimmune disease, as a preceding disease, suggesting that anti-NMDAR encephalitis itself is caused by a parainfectious autoimmune mechanism.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemical demonstration of antibodies against NMDAR. a CSF of the patient showing positive immunoreactivity against heteromers of NR1 and NR2B subunits of NMDAR. b Anti-rabbit IgG showing positive immunoreactivity against NR1 subunit of NMDAR. c Merge image. Arrows indicate positively stained HEK cells. Immunofluorescence staining (×200).
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Figure 3: Immunohistochemical demonstration of antibodies against NMDAR. a CSF of the patient showing positive immunoreactivity against heteromers of NR1 and NR2B subunits of NMDAR. b Anti-rabbit IgG showing positive immunoreactivity against NR1 subunit of NMDAR. c Merge image. Arrows indicate positively stained HEK cells. Immunofluorescence staining (×200).

Mentions: Both serum and CSF obtained from the 92nd hospital day specifically reacted with HEK-293 cells expressing heteromers of NR1/NR2B (fig. 3).


A Young Man with Anti-NMDAR Encephalitis following Guillain-Barré Syndrome.

Tojo K, Nitta K, Ishii W, Sekijima Y, Morita H, Takahashi Y, Tanaka K, Ikeda S - Case Rep Neurol (2011)

Immunohistochemical demonstration of antibodies against NMDAR. a CSF of the patient showing positive immunoreactivity against heteromers of NR1 and NR2B subunits of NMDAR. b Anti-rabbit IgG showing positive immunoreactivity against NR1 subunit of NMDAR. c Merge image. Arrows indicate positively stained HEK cells. Immunofluorescence staining (×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3037987&req=5

Figure 3: Immunohistochemical demonstration of antibodies against NMDAR. a CSF of the patient showing positive immunoreactivity against heteromers of NR1 and NR2B subunits of NMDAR. b Anti-rabbit IgG showing positive immunoreactivity against NR1 subunit of NMDAR. c Merge image. Arrows indicate positively stained HEK cells. Immunofluorescence staining (×200).
Mentions: Both serum and CSF obtained from the 92nd hospital day specifically reacted with HEK-293 cells expressing heteromers of NR1/NR2B (fig. 3).

Bottom Line: Anti-N-methyl-D-aspartate receptor (NMDAR) antibodies in serum and cerebrospinal fluid were positive on the 92nd hospital day.Anti-NMDAR encephalitis usually affects young females but a small number of male cases with this disease have been reported.Our male patient was unique in having GBS, a post-infectious autoimmune disease, as a preceding disease, suggesting that anti-NMDAR encephalitis itself is caused by a parainfectious autoimmune mechanism.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.

ABSTRACT
A 19-year-old man developed rapidly progressive muscle weakness and dysesthesia in the extremities, and dyspnea after a flu-like episode. Nerve conduction studies showed reduced motor nerve conduction velocities with conduction block, and sensory nerve action potentials could not be evoked. The patient was diagnosed as having Guillain-Barré syndrome (GBS), and was treated with 2 cycles of intravenous immunoglobulin (IVIg) therapy and was assisted by mechanical ventilation. During the recovery course of the illness, he experienced several attacks of psychomotor agitation from the 37th hospital day, and generalized tonic convulsive seizures suddenly developed on the 42nd hospital day. Brain MRI showed high-intensity lesions in the bilateral thalamus and medial temporal lobes. The convulsions were controlled by continuous thiopental infusion (until the 50th hospital day) and mechanical ventilation (until the 84th hospital day). Intravenous methylprednisolone pulse therapy (1,000 mg/day) for 3 days followed by dexamethasone (16 mg/day) was added. After relief of convulsive seizures, prominent orolingual dyskinesia appeared, and on MRI marked atrophy of the bilateral medial temporal lobes was seen. Anti-N-methyl-D-aspartate receptor (NMDAR) antibodies in serum and cerebrospinal fluid were positive on the 92nd hospital day. Anti-NMDAR encephalitis usually affects young females but a small number of male cases with this disease have been reported. Our male patient was unique in having GBS, a post-infectious autoimmune disease, as a preceding disease, suggesting that anti-NMDAR encephalitis itself is caused by a parainfectious autoimmune mechanism.

No MeSH data available.


Related in: MedlinePlus