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Variant Plasmodium ovale isolated from a patient infected in Ghana.

Tordrup D, Virenfeldt J, Andersen FF, Petersen E - Malar. J. (2011)

Bottom Line: Recent data have found that Plasmodium ovale can be separated in two distinct species: classic and variant P. ovale based on multilocus typing of different genes.This study presents a P. ovale isolate from a patient infected in Ghana together with an analysis of the small subunit RNA, cytochrome b, cytochrome c oxidase I, cysteine protease and lactate dehydrogenase genes, which show that the sample is a variant P. ovale and identical or highly similar to variant P. ovale isolated from humans in South-East Asia and Africa, and from a chimpanzee in Cameroon.The split between the variant and classic P. ovale is estimated to have occurred 1.7 million years ago.

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Affiliation: Department of Infectious Diseases, Institute of Clinical Medicine, Aarhus University Hospital-Skejby, Aarhus N., Denmark.

ABSTRACT
Recent data have found that Plasmodium ovale can be separated in two distinct species: classic and variant P. ovale based on multilocus typing of different genes. This study presents a P. ovale isolate from a patient infected in Ghana together with an analysis of the small subunit RNA, cytochrome b, cytochrome c oxidase I, cysteine protease and lactate dehydrogenase genes, which show that the sample is a variant P. ovale and identical or highly similar to variant P. ovale isolated from humans in South-East Asia and Africa, and from a chimpanzee in Cameroon. The split between the variant and classic P. ovale is estimated to have occurred 1.7 million years ago.

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Giemsa stained, thin blood film showing P. ovale throphozoite with Schüffner dots (A and B); a P.ovale gametocyte (C); and an early schizont with two chromatin dots (D).
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Figure 1: Giemsa stained, thin blood film showing P. ovale throphozoite with Schüffner dots (A and B); a P.ovale gametocyte (C); and an early schizont with two chromatin dots (D).

Mentions: Thick and thin blood films showed a P. ovale infection with an initial parasitaemia of 0.5% and numeration of the parasite density found 11,600 parasites per μl blood (Figure 1). The second day the parasitaemia was estimated to 0.1% with a density of 1,100 parasites per μl blood. Quick-test (Binax, Bedford, UK) was negative. Chest X-ray showed pneumonia on the left side, and the patient was treated with ceftriaxone intravenously.


Variant Plasmodium ovale isolated from a patient infected in Ghana.

Tordrup D, Virenfeldt J, Andersen FF, Petersen E - Malar. J. (2011)

Giemsa stained, thin blood film showing P. ovale throphozoite with Schüffner dots (A and B); a P.ovale gametocyte (C); and an early schizont with two chromatin dots (D).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3037929&req=5

Figure 1: Giemsa stained, thin blood film showing P. ovale throphozoite with Schüffner dots (A and B); a P.ovale gametocyte (C); and an early schizont with two chromatin dots (D).
Mentions: Thick and thin blood films showed a P. ovale infection with an initial parasitaemia of 0.5% and numeration of the parasite density found 11,600 parasites per μl blood (Figure 1). The second day the parasitaemia was estimated to 0.1% with a density of 1,100 parasites per μl blood. Quick-test (Binax, Bedford, UK) was negative. Chest X-ray showed pneumonia on the left side, and the patient was treated with ceftriaxone intravenously.

Bottom Line: Recent data have found that Plasmodium ovale can be separated in two distinct species: classic and variant P. ovale based on multilocus typing of different genes.This study presents a P. ovale isolate from a patient infected in Ghana together with an analysis of the small subunit RNA, cytochrome b, cytochrome c oxidase I, cysteine protease and lactate dehydrogenase genes, which show that the sample is a variant P. ovale and identical or highly similar to variant P. ovale isolated from humans in South-East Asia and Africa, and from a chimpanzee in Cameroon.The split between the variant and classic P. ovale is estimated to have occurred 1.7 million years ago.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Infectious Diseases, Institute of Clinical Medicine, Aarhus University Hospital-Skejby, Aarhus N., Denmark.

ABSTRACT
Recent data have found that Plasmodium ovale can be separated in two distinct species: classic and variant P. ovale based on multilocus typing of different genes. This study presents a P. ovale isolate from a patient infected in Ghana together with an analysis of the small subunit RNA, cytochrome b, cytochrome c oxidase I, cysteine protease and lactate dehydrogenase genes, which show that the sample is a variant P. ovale and identical or highly similar to variant P. ovale isolated from humans in South-East Asia and Africa, and from a chimpanzee in Cameroon. The split between the variant and classic P. ovale is estimated to have occurred 1.7 million years ago.

Show MeSH