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Scintigraphic features of Morquio's syndrome: a case report.

Kitzing B, Allman KC - J Med Case Rep (2011)

Bottom Line: A 46-year-old Caucasian man with Morquio's syndrome presented with lower back pain six weeks after a left total hip replacement.A whole body bone scan demonstrated an anthropomorphic skeletal pattern consistent with a mucopolysaccharide storage disease, thereby showing the cause of the patient's pain.We present our case report to add to the knowledge we have of this rare disease.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Missenden Road, Sydney, New South Wales, Australia. bkitzing@gmail.com.

ABSTRACT

Introduction: To the best of our knowledge, we present for the first time the bone scintigraphy findings of a patient with Morquio's syndrome.

Case presentation: A 46-year-old Caucasian man with Morquio's syndrome presented with lower back pain six weeks after a left total hip replacement. A whole body bone scan demonstrated an anthropomorphic skeletal pattern consistent with a mucopolysaccharide storage disease, thereby showing the cause of the patient's pain.

Conclusions: To the best of our knowledge, the bone scintigraphy findings of a case of Morquio's syndrome have never before been published. We present our case report to add to the knowledge we have of this rare disease.

No MeSH data available.


Related in: MedlinePlus

Anterior and posterior whole body bone scan views of a 46-year-old Caucasian man with Morquio's syndrome complaining of lower back pain. The anthropomorphic skeletal uptake pattern is consistent with a mucopolysaccharide storage disease.
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Figure 1: Anterior and posterior whole body bone scan views of a 46-year-old Caucasian man with Morquio's syndrome complaining of lower back pain. The anthropomorphic skeletal uptake pattern is consistent with a mucopolysaccharide storage disease.

Mentions: A 46-year-old Caucasian man with Morquio's syndrome presented to our nuclear medicine department for a whole body bone scan. He had been complaining of lower back pain for six weeks following a left total hip replacement. He had been referred to our facility for bone imaging by his general practitioner. Whole body anterior and posterior static views were obtained three hours after an injection of 800MBq Tc-99m methylene diphosphonate, demonstrating an anthropomorphic skeletal uptake pattern consistent with Morquio's syndrome. The known radiological features of Morquio's syndrome include short-trunk dwarfism, a shortened neck with the head appearing sunken into the chest, broad flat ilia, widespread degenerative disease and skeletal dysplasia [2]. These features were confirmed on the bone scintigraphy (Figures 1, 2, 3). The scan also showed that he had had both hips replaced. The unusual tracer uptake in the proximal part of both tibias was due to previous shorteningand straightening procedures. There was increased peri-prosthetic uptake in his left hip in keeping with a recent hip replacement (Figure 2). Focal increased uptake was observed in his right sacroiliac joint and sacral body, consistent with fractures, and this was the most likely cause of his pain (Figure 3). There was also increased linear uptake in his lower thoracic spine consistent with an old crush fracture. The bone scan report was sent to the general practitioner with whom our patient had a follow-up appointment.


Scintigraphic features of Morquio's syndrome: a case report.

Kitzing B, Allman KC - J Med Case Rep (2011)

Anterior and posterior whole body bone scan views of a 46-year-old Caucasian man with Morquio's syndrome complaining of lower back pain. The anthropomorphic skeletal uptake pattern is consistent with a mucopolysaccharide storage disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3037887&req=5

Figure 1: Anterior and posterior whole body bone scan views of a 46-year-old Caucasian man with Morquio's syndrome complaining of lower back pain. The anthropomorphic skeletal uptake pattern is consistent with a mucopolysaccharide storage disease.
Mentions: A 46-year-old Caucasian man with Morquio's syndrome presented to our nuclear medicine department for a whole body bone scan. He had been complaining of lower back pain for six weeks following a left total hip replacement. He had been referred to our facility for bone imaging by his general practitioner. Whole body anterior and posterior static views were obtained three hours after an injection of 800MBq Tc-99m methylene diphosphonate, demonstrating an anthropomorphic skeletal uptake pattern consistent with Morquio's syndrome. The known radiological features of Morquio's syndrome include short-trunk dwarfism, a shortened neck with the head appearing sunken into the chest, broad flat ilia, widespread degenerative disease and skeletal dysplasia [2]. These features were confirmed on the bone scintigraphy (Figures 1, 2, 3). The scan also showed that he had had both hips replaced. The unusual tracer uptake in the proximal part of both tibias was due to previous shorteningand straightening procedures. There was increased peri-prosthetic uptake in his left hip in keeping with a recent hip replacement (Figure 2). Focal increased uptake was observed in his right sacroiliac joint and sacral body, consistent with fractures, and this was the most likely cause of his pain (Figure 3). There was also increased linear uptake in his lower thoracic spine consistent with an old crush fracture. The bone scan report was sent to the general practitioner with whom our patient had a follow-up appointment.

Bottom Line: A 46-year-old Caucasian man with Morquio's syndrome presented with lower back pain six weeks after a left total hip replacement.A whole body bone scan demonstrated an anthropomorphic skeletal pattern consistent with a mucopolysaccharide storage disease, thereby showing the cause of the patient's pain.We present our case report to add to the knowledge we have of this rare disease.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Missenden Road, Sydney, New South Wales, Australia. bkitzing@gmail.com.

ABSTRACT

Introduction: To the best of our knowledge, we present for the first time the bone scintigraphy findings of a patient with Morquio's syndrome.

Case presentation: A 46-year-old Caucasian man with Morquio's syndrome presented with lower back pain six weeks after a left total hip replacement. A whole body bone scan demonstrated an anthropomorphic skeletal pattern consistent with a mucopolysaccharide storage disease, thereby showing the cause of the patient's pain.

Conclusions: To the best of our knowledge, the bone scintigraphy findings of a case of Morquio's syndrome have never before been published. We present our case report to add to the knowledge we have of this rare disease.

No MeSH data available.


Related in: MedlinePlus