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Cortical modulation of the transient visual response at thalamic level: a TMS study.

Espinosa N, Mariño J, de Labra C, Cudeiro J - PLoS ONE (2011)

Bottom Line: The results show that rTMS@1Hz modulates the firing mode of Y cells, inducing an increase in burst spikes and a decrease in tonic firing.On the other hand, rTMS@1Hz modifies the spatiotemporal characteristics of receptive fields of X cells, inducing a delay and a decrease of the peak response, and a change of the surround/center amplitude ratio of RF profiles.These results indicate that V1 controls the activity of the visual thalamus in a different way in the X and Y pathways, and that this feedback control is consistent with functional roles associated with each cell type.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience and Motor Control Group (NEUROcom) and Biomedical Institute of A Coruña (INIBIC), University of A Coruña, A Coruña, Spain.

ABSTRACT
The transient visual response of feline dorsal lateral geniculate nucleus (dLGN) cells was studied under control conditions and during the application of repetitive transcranial magnetic stimulation at 1 Hz (rTMS@1Hz) on the primary visual cortex (V1). The results show that rTMS@1Hz modulates the firing mode of Y cells, inducing an increase in burst spikes and a decrease in tonic firing. On the other hand, rTMS@1Hz modifies the spatiotemporal characteristics of receptive fields of X cells, inducing a delay and a decrease of the peak response, and a change of the surround/center amplitude ratio of RF profiles. These results indicate that V1 controls the activity of the visual thalamus in a different way in the X and Y pathways, and that this feedback control is consistent with functional roles associated with each cell type.

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Analysis of Y dLGN cells whose percentage of response in burst was less than 40–50%.rTMS@1Hz increased the percentage of spikes in burst (A) and consequently decreased tonic spikes (B). Changes in response mode were reflected, as well, in the number of bursts (C). D–F, rTMS@1Hz did not alter the response mode of Y dLGN cells whose percentage of response in burst was more than 40–50%. G, An example of a Y dLGN cell response whose percentage of spikes in burst during control condition (black line) was 29%. rTMS@1Hz increased spikes in burst to 38% (gray line, bin = 2 ms). Vertical error bars represent the standard error of the mean.
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pone-0017041-g003: Analysis of Y dLGN cells whose percentage of response in burst was less than 40–50%.rTMS@1Hz increased the percentage of spikes in burst (A) and consequently decreased tonic spikes (B). Changes in response mode were reflected, as well, in the number of bursts (C). D–F, rTMS@1Hz did not alter the response mode of Y dLGN cells whose percentage of response in burst was more than 40–50%. G, An example of a Y dLGN cell response whose percentage of spikes in burst during control condition (black line) was 29%. rTMS@1Hz increased spikes in burst to 38% (gray line, bin = 2 ms). Vertical error bars represent the standard error of the mean.

Mentions: Neurons with a low percentage of bursts, i.e. the proportion of spikes in bursts was below 40–50% (n = 18), showed a significant increase in the percentage of spikes in bursts when rTMS@1Hz was applied, as it is shown in Figure 3A (21.1±2.2% to 24.0±2.2%, P<0.05, paired t-test) and therefore a decrease in the percentage of tonic spikes (78.9±2.2% to 76.0±2.2%, P<0.05, paired t-test, Figure 3B). Considering each burst as an event, rTMS@1Hz application induced an 11.0% increase in the number of bursts (from 143.2±17.7 to 162.5±19.0, P<0.05, paired t-test, Figure 3C).


Cortical modulation of the transient visual response at thalamic level: a TMS study.

Espinosa N, Mariño J, de Labra C, Cudeiro J - PLoS ONE (2011)

Analysis of Y dLGN cells whose percentage of response in burst was less than 40–50%.rTMS@1Hz increased the percentage of spikes in burst (A) and consequently decreased tonic spikes (B). Changes in response mode were reflected, as well, in the number of bursts (C). D–F, rTMS@1Hz did not alter the response mode of Y dLGN cells whose percentage of response in burst was more than 40–50%. G, An example of a Y dLGN cell response whose percentage of spikes in burst during control condition (black line) was 29%. rTMS@1Hz increased spikes in burst to 38% (gray line, bin = 2 ms). Vertical error bars represent the standard error of the mean.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3037393&req=5

pone-0017041-g003: Analysis of Y dLGN cells whose percentage of response in burst was less than 40–50%.rTMS@1Hz increased the percentage of spikes in burst (A) and consequently decreased tonic spikes (B). Changes in response mode were reflected, as well, in the number of bursts (C). D–F, rTMS@1Hz did not alter the response mode of Y dLGN cells whose percentage of response in burst was more than 40–50%. G, An example of a Y dLGN cell response whose percentage of spikes in burst during control condition (black line) was 29%. rTMS@1Hz increased spikes in burst to 38% (gray line, bin = 2 ms). Vertical error bars represent the standard error of the mean.
Mentions: Neurons with a low percentage of bursts, i.e. the proportion of spikes in bursts was below 40–50% (n = 18), showed a significant increase in the percentage of spikes in bursts when rTMS@1Hz was applied, as it is shown in Figure 3A (21.1±2.2% to 24.0±2.2%, P<0.05, paired t-test) and therefore a decrease in the percentage of tonic spikes (78.9±2.2% to 76.0±2.2%, P<0.05, paired t-test, Figure 3B). Considering each burst as an event, rTMS@1Hz application induced an 11.0% increase in the number of bursts (from 143.2±17.7 to 162.5±19.0, P<0.05, paired t-test, Figure 3C).

Bottom Line: The results show that rTMS@1Hz modulates the firing mode of Y cells, inducing an increase in burst spikes and a decrease in tonic firing.On the other hand, rTMS@1Hz modifies the spatiotemporal characteristics of receptive fields of X cells, inducing a delay and a decrease of the peak response, and a change of the surround/center amplitude ratio of RF profiles.These results indicate that V1 controls the activity of the visual thalamus in a different way in the X and Y pathways, and that this feedback control is consistent with functional roles associated with each cell type.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience and Motor Control Group (NEUROcom) and Biomedical Institute of A Coruña (INIBIC), University of A Coruña, A Coruña, Spain.

ABSTRACT
The transient visual response of feline dorsal lateral geniculate nucleus (dLGN) cells was studied under control conditions and during the application of repetitive transcranial magnetic stimulation at 1 Hz (rTMS@1Hz) on the primary visual cortex (V1). The results show that rTMS@1Hz modulates the firing mode of Y cells, inducing an increase in burst spikes and a decrease in tonic firing. On the other hand, rTMS@1Hz modifies the spatiotemporal characteristics of receptive fields of X cells, inducing a delay and a decrease of the peak response, and a change of the surround/center amplitude ratio of RF profiles. These results indicate that V1 controls the activity of the visual thalamus in a different way in the X and Y pathways, and that this feedback control is consistent with functional roles associated with each cell type.

Show MeSH