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Association between nasal shedding and fever that influenza A (H3N2) induces in dogs.

Song D, Moon H, Jung K, Yeom M, Kim H, Han S, An D, Oh J, Kim J, Park B, Kang B - Virol. J. (2011)

Bottom Line: Clinical signs including fever were recorded for 14 days post inoculation.The mean viral titer during fever was 2.99 log EID₅₀/ml, which was significantly higher than the viral titer detected in the non fever.The data show that contact dogs with a canine influenza infected dog shed different levels of virus in their nasal excretions and demonstrate that clinical signs, including fever, significantly correlate with the viral shedding.

View Article: PubMed Central - HTML - PubMed

Affiliation: Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-806, Korea.

ABSTRACT

Background: Avian origin canine influenza virus was reported in Korea. The dog to dog contact transmission of the avian origin canine influenza virus (CIV) H3N2 and CIV H3N8 was shown by experimental contact transmission. This study was focused on viral excretion and fever in order to elucidate the epidemiological associations which might be helpful to control the disease transmissions in CIV outbreak in dogs.

Methods: An influenza seronegative 10-week-old Beagle dog was experimentally inoculated with the canine influenza virus A/canine/01/2007, subtype H3N2. Eight hours after inoculation, the infected dog was cohoused with seven uninfected Beagle dogs. Clinical signs including fever were recorded for 14 days post inoculation.

Results: The infected dog and four of seven contact dogs in the study showed clinical signs (sneezing, nasal discharge and coughing) during the study. Viral shedding occurred in all of the animals tested and began on 1 to 6 DPI in dogs with clinical signs. Elevated body temperatures above 39.5 °C (geometric mean temperature of 39.86 °C ± 0.49) were observed in all symptomatic dogs. The mean viral titer during fever was 2.99 log EID₅₀/ml, which was significantly higher than the viral titer detected in the non fever.

Conclusions: The data show that contact dogs with a canine influenza infected dog shed different levels of virus in their nasal excretions and demonstrate that clinical signs, including fever, significantly correlate with the viral shedding.

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Related in: MedlinePlus

Levels of CIV shed in the nasal discharge of dogs with and without clinical signs. The daily levels of viral shedding are expressed as the log EID50/ml from five individual dogs with clinical signs (A) and three dogs without clinical signs (B). Body temperatures (°C) were also compared between dogs with (C) and without (D) clinical signs.
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Figure 1: Levels of CIV shed in the nasal discharge of dogs with and without clinical signs. The daily levels of viral shedding are expressed as the log EID50/ml from five individual dogs with clinical signs (A) and three dogs without clinical signs (B). Body temperatures (°C) were also compared between dogs with (C) and without (D) clinical signs.

Mentions: The infected dog and four of seven contact dogs in the study showed clinical signs (sneezing, nasal discharge and coughing) during the study, while 3 dogs lacked symptoms. All of the animals seroconverted as assessed by a CIV competitive ELISA (data not shown). Clinical signs were observed from 4 to 8 DPI, and viral shedding was detected earlier in dogs with clinical signs than those without (Figure 1).


Association between nasal shedding and fever that influenza A (H3N2) induces in dogs.

Song D, Moon H, Jung K, Yeom M, Kim H, Han S, An D, Oh J, Kim J, Park B, Kang B - Virol. J. (2011)

Levels of CIV shed in the nasal discharge of dogs with and without clinical signs. The daily levels of viral shedding are expressed as the log EID50/ml from five individual dogs with clinical signs (A) and three dogs without clinical signs (B). Body temperatures (°C) were also compared between dogs with (C) and without (D) clinical signs.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3025961&req=5

Figure 1: Levels of CIV shed in the nasal discharge of dogs with and without clinical signs. The daily levels of viral shedding are expressed as the log EID50/ml from five individual dogs with clinical signs (A) and three dogs without clinical signs (B). Body temperatures (°C) were also compared between dogs with (C) and without (D) clinical signs.
Mentions: The infected dog and four of seven contact dogs in the study showed clinical signs (sneezing, nasal discharge and coughing) during the study, while 3 dogs lacked symptoms. All of the animals seroconverted as assessed by a CIV competitive ELISA (data not shown). Clinical signs were observed from 4 to 8 DPI, and viral shedding was detected earlier in dogs with clinical signs than those without (Figure 1).

Bottom Line: Clinical signs including fever were recorded for 14 days post inoculation.The mean viral titer during fever was 2.99 log EID₅₀/ml, which was significantly higher than the viral titer detected in the non fever.The data show that contact dogs with a canine influenza infected dog shed different levels of virus in their nasal excretions and demonstrate that clinical signs, including fever, significantly correlate with the viral shedding.

View Article: PubMed Central - HTML - PubMed

Affiliation: Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-806, Korea.

ABSTRACT

Background: Avian origin canine influenza virus was reported in Korea. The dog to dog contact transmission of the avian origin canine influenza virus (CIV) H3N2 and CIV H3N8 was shown by experimental contact transmission. This study was focused on viral excretion and fever in order to elucidate the epidemiological associations which might be helpful to control the disease transmissions in CIV outbreak in dogs.

Methods: An influenza seronegative 10-week-old Beagle dog was experimentally inoculated with the canine influenza virus A/canine/01/2007, subtype H3N2. Eight hours after inoculation, the infected dog was cohoused with seven uninfected Beagle dogs. Clinical signs including fever were recorded for 14 days post inoculation.

Results: The infected dog and four of seven contact dogs in the study showed clinical signs (sneezing, nasal discharge and coughing) during the study. Viral shedding occurred in all of the animals tested and began on 1 to 6 DPI in dogs with clinical signs. Elevated body temperatures above 39.5 °C (geometric mean temperature of 39.86 °C ± 0.49) were observed in all symptomatic dogs. The mean viral titer during fever was 2.99 log EID₅₀/ml, which was significantly higher than the viral titer detected in the non fever.

Conclusions: The data show that contact dogs with a canine influenza infected dog shed different levels of virus in their nasal excretions and demonstrate that clinical signs, including fever, significantly correlate with the viral shedding.

Show MeSH
Related in: MedlinePlus