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Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling.

Packer L, Cadenas E - J Clin Biochem Nutr (2010)

Bottom Line: The diversity of beneficial effects of lipoic acid in a variety of tissues can be mechanistically viewed in terms of thiol/disulfide exchange reactions that modulate the environment's redox and energy status.Lipoic acid-driven thiol/disulfide exchange reactions appear critical for the modulation of proteins involved in cell signaling and transcription factors.This review emphasizes the effects of lipoic acid on PI3K and AMPK signaling and related transcriptional pathways that are integrated by PGC-1α, a critical regulator of energy homoestasis.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.

ABSTRACT
The role of R-α-lipoic acid as a cofactor (lipoyllysine) in mitochondrial energy metabolism is well established. Lipoic acid non-covalently bound and exogenously administered to cells or supplemented in the diet is a potent modulator of the cell's redox status. The diversity of beneficial effects of lipoic acid in a variety of tissues can be mechanistically viewed in terms of thiol/disulfide exchange reactions that modulate the environment's redox and energy status. Lipoic acid-driven thiol/disulfide exchange reactions appear critical for the modulation of proteins involved in cell signaling and transcription factors. This review emphasizes the effects of lipoic acid on PI3K and AMPK signaling and related transcriptional pathways that are integrated by PGC-1α, a critical regulator of energy homoestasis. The effects of lipoic acid on the neuronal energy-redox axis are largely reviewed in terms of their outcomes for aging and age-related neurodegenerative diseases.

No MeSH data available.


Related in: MedlinePlus

The insulin-like effect of lipoic acid and Akt-dependent stimulation of mitochondrial function.
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Related In: Results  -  Collection


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Figure 4: The insulin-like effect of lipoic acid and Akt-dependent stimulation of mitochondrial function.

Mentions: Full activation of Akt is a complex process entailing different pathways;(41) Akt activation affects mitochondrial bioenergetics by at least two pathways (Fig. 4).


Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling.

Packer L, Cadenas E - J Clin Biochem Nutr (2010)

The insulin-like effect of lipoic acid and Akt-dependent stimulation of mitochondrial function.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3022059&req=5

Figure 4: The insulin-like effect of lipoic acid and Akt-dependent stimulation of mitochondrial function.
Mentions: Full activation of Akt is a complex process entailing different pathways;(41) Akt activation affects mitochondrial bioenergetics by at least two pathways (Fig. 4).

Bottom Line: The diversity of beneficial effects of lipoic acid in a variety of tissues can be mechanistically viewed in terms of thiol/disulfide exchange reactions that modulate the environment's redox and energy status.Lipoic acid-driven thiol/disulfide exchange reactions appear critical for the modulation of proteins involved in cell signaling and transcription factors.This review emphasizes the effects of lipoic acid on PI3K and AMPK signaling and related transcriptional pathways that are integrated by PGC-1α, a critical regulator of energy homoestasis.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.

ABSTRACT
The role of R-α-lipoic acid as a cofactor (lipoyllysine) in mitochondrial energy metabolism is well established. Lipoic acid non-covalently bound and exogenously administered to cells or supplemented in the diet is a potent modulator of the cell's redox status. The diversity of beneficial effects of lipoic acid in a variety of tissues can be mechanistically viewed in terms of thiol/disulfide exchange reactions that modulate the environment's redox and energy status. Lipoic acid-driven thiol/disulfide exchange reactions appear critical for the modulation of proteins involved in cell signaling and transcription factors. This review emphasizes the effects of lipoic acid on PI3K and AMPK signaling and related transcriptional pathways that are integrated by PGC-1α, a critical regulator of energy homoestasis. The effects of lipoic acid on the neuronal energy-redox axis are largely reviewed in terms of their outcomes for aging and age-related neurodegenerative diseases.

No MeSH data available.


Related in: MedlinePlus