Accelerated cardiac magnetic resonance imaging in the mouse using an eight-channel array at 9.4 Tesla.
Bottom Line: Parallel imaging techniques to reduce acquisition times require coil arrays, which are technically challenging to design at ultrahigh magnetic field strengths.The results demonstrate that a threefold accelerated data acquisition is generally feasible without compromising the accuracy of the results.This strategy may eventually pave the way for routine, multiparametric phenotyping of mouse hearts in vivo within one imaging session of tolerable duration.
Affiliation: British Heart Foundation Experimental MR Unit (BMRU), Department of Cardiovascular Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom. email@example.comShow MeSH
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Mentions: Cardiac functional parameters and LV mass measurements obtained by a single blinded observer for TP3 are summarized in Table 1. There was no statistically significant difference between measurements for any of the functional parameters. Quantitative analysis was highly reproducible with low variability (overall intraobserver variability 6 ± 6% for both, birdcage coil and TGRAPPA, R = 3 datasets; intervariability assessed in three randomly selected datasets: 4.5 ± 3.2 %). Bland-Altman plots for LV mass, EDV, ESV and EF obtained from the birdcage coil compared with threefold accelerated data are shown in Fig. 5a–d. While all data points were contained within the ±2 SD range, there was a positive bias for LV mass (5.2 mg), EDV (4.7 μL) and for ESV (4.6 μL) indicating that volumes measured from the birdcage coil data were larger than those obtained from the TGRAPPA, R = 3 datasets. There was a small negative bias for EF (−3.8%).
Affiliation: British Heart Foundation Experimental MR Unit (BMRU), Department of Cardiovascular Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom. firstname.lastname@example.org