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Possible role of hydrogen sulfide in insulin secretion and in development of insulin resistance.

Patel M, Shah G - J Young Pharm (2010)

Bottom Line: H2S is the gaseous K(+) ATP channel opener but it does not have channel specificity.From the result of our study, H(2)S have K(+) ATP channel opening activity on β cells.Decrease in insulin level in Zuker diabetic rat and streptozotocin-induced diabetic rat is due to high H(2)S level.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, C.K Pithawala Institute of Pharmaceutical Science and Research, Near Magdalla port, Surat, India.

ABSTRACT
H(2)S has been proposed as physiological important molecule. It is considered as first endogenous gaseous K(+) channel opener. K(+) ATP channel activity is mainly responsible for insulin secretion. K(+)ATP channel opening of β cells leads to inhibition of insulin secretion and channels closing leads to secretion. H2S is the gaseous K(+) ATP channel opener but it does not have channel specificity. So, H(2)S may have some effect on insulin secretion. H(2)S is high in Zuker diabetic fatty rats. That means H(2)S is high in insulin resistance condition. We tried to find out the role of H(2)S in insulin secretion and in development of insulin resistance. From the result of our study, H(2)S have K(+) ATP channel opening activity on β cells. H(2)S does not have any role in the development of insulin resistance. Decrease in insulin level in Zuker diabetic rat and streptozotocin-induced diabetic rat is due to high H(2)S level.

No MeSH data available.


Related in: MedlinePlus

Effect of chronic administration of H2S on oral glucose tolerance. Each value is mean±SEM, *P<0.05
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Figure 0002: Effect of chronic administration of H2S on oral glucose tolerance. Each value is mean±SEM, *P<0.05

Mentions: After chronic treatment with H2S, oral glucose tolerance test was performed along with administration of insulin 1 U/kg i.m to check the development of insulin sensitivity. Glucose level was measured after administration of glucose 5 g/kg p.o. There was no significant difference in glucose level compared to normal animals [Figure 2]. Also there was no significant difference in insulin and glucose level before and after chronic administration of H2S [Table 3].


Possible role of hydrogen sulfide in insulin secretion and in development of insulin resistance.

Patel M, Shah G - J Young Pharm (2010)

Effect of chronic administration of H2S on oral glucose tolerance. Each value is mean±SEM, *P<0.05
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3021689&req=5

Figure 0002: Effect of chronic administration of H2S on oral glucose tolerance. Each value is mean±SEM, *P<0.05
Mentions: After chronic treatment with H2S, oral glucose tolerance test was performed along with administration of insulin 1 U/kg i.m to check the development of insulin sensitivity. Glucose level was measured after administration of glucose 5 g/kg p.o. There was no significant difference in glucose level compared to normal animals [Figure 2]. Also there was no significant difference in insulin and glucose level before and after chronic administration of H2S [Table 3].

Bottom Line: H2S is the gaseous K(+) ATP channel opener but it does not have channel specificity.From the result of our study, H(2)S have K(+) ATP channel opening activity on β cells.Decrease in insulin level in Zuker diabetic rat and streptozotocin-induced diabetic rat is due to high H(2)S level.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, C.K Pithawala Institute of Pharmaceutical Science and Research, Near Magdalla port, Surat, India.

ABSTRACT
H(2)S has been proposed as physiological important molecule. It is considered as first endogenous gaseous K(+) channel opener. K(+) ATP channel activity is mainly responsible for insulin secretion. K(+)ATP channel opening of β cells leads to inhibition of insulin secretion and channels closing leads to secretion. H2S is the gaseous K(+) ATP channel opener but it does not have channel specificity. So, H(2)S may have some effect on insulin secretion. H(2)S is high in Zuker diabetic fatty rats. That means H(2)S is high in insulin resistance condition. We tried to find out the role of H(2)S in insulin secretion and in development of insulin resistance. From the result of our study, H(2)S have K(+) ATP channel opening activity on β cells. H(2)S does not have any role in the development of insulin resistance. Decrease in insulin level in Zuker diabetic rat and streptozotocin-induced diabetic rat is due to high H(2)S level.

No MeSH data available.


Related in: MedlinePlus