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Formulation and evaluation of extended-release solid dispersion of metformin hydrochloride.

Patil S, Kuchekar B, Chabukswar A, Jagdale S - J Young Pharm (2010)

Bottom Line: The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method.The optimized formulation was subjected to accelerated stability testing as per ICH guidelines.SD with 1:4 and 1:5 ratio of drug to polymer obtained by solvent evaporation and cogrinding were selected as the best candidates suitable for prolonged-release oral dosage form of metformin.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, MAEER's Maharashtra Institute of Pharmacy, Pune - 411 038, Maharashtra, India.

ABSTRACT
The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calorimetry and X-ray powder diffractometry. The optimized formulation was subjected to accelerated stability testing as per ICH guidelines. Release data were examined kinetically. SD with 1:4 and 1:5 ratio of drug to polymer obtained by solvent evaporation and cogrinding were selected as the best candidates suitable for prolonged-release oral dosage form of metformin.

No MeSH data available.


FTIR spectra of metformin hydrochloride, methocel K100M, physical mixtures and solid dispersions by the cogrinding method
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Figure 0004: FTIR spectra of metformin hydrochloride, methocel K100M, physical mixtures and solid dispersions by the cogrinding method

Mentions: The FTIR spectrum of pure MET showed two typical bands at 3369 cm-1 and 3294 cm-1 relative to the N–H primary stretching vibration and a band at 3155 cm-1 due to the N– secondary stretching, and characteristic bands at 1626 cm-1 and 1567 cm-1, assigned to C-N stretching. IR spectra of HPMC shows typical bands at 3451 cm-1 due to O-H stretching, 1644 cm-1 due to sugar ring and 1064 cm-1 due to C-O (etheric) stretching. The physical mixture spectrum [Figures 3 and 4] can be considered as the sum of pure MET and HPMC spectra. The absolute zero changes of the peak shift in case of physical mixture observed as subtraction of HPMC spectra from PM spectra revealed the pure MET spectra.


Formulation and evaluation of extended-release solid dispersion of metformin hydrochloride.

Patil S, Kuchekar B, Chabukswar A, Jagdale S - J Young Pharm (2010)

FTIR spectra of metformin hydrochloride, methocel K100M, physical mixtures and solid dispersions by the cogrinding method
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3021685&req=5

Figure 0004: FTIR spectra of metformin hydrochloride, methocel K100M, physical mixtures and solid dispersions by the cogrinding method
Mentions: The FTIR spectrum of pure MET showed two typical bands at 3369 cm-1 and 3294 cm-1 relative to the N–H primary stretching vibration and a band at 3155 cm-1 due to the N– secondary stretching, and characteristic bands at 1626 cm-1 and 1567 cm-1, assigned to C-N stretching. IR spectra of HPMC shows typical bands at 3451 cm-1 due to O-H stretching, 1644 cm-1 due to sugar ring and 1064 cm-1 due to C-O (etheric) stretching. The physical mixture spectrum [Figures 3 and 4] can be considered as the sum of pure MET and HPMC spectra. The absolute zero changes of the peak shift in case of physical mixture observed as subtraction of HPMC spectra from PM spectra revealed the pure MET spectra.

Bottom Line: The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method.The optimized formulation was subjected to accelerated stability testing as per ICH guidelines.SD with 1:4 and 1:5 ratio of drug to polymer obtained by solvent evaporation and cogrinding were selected as the best candidates suitable for prolonged-release oral dosage form of metformin.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, MAEER's Maharashtra Institute of Pharmacy, Pune - 411 038, Maharashtra, India.

ABSTRACT
The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calorimetry and X-ray powder diffractometry. The optimized formulation was subjected to accelerated stability testing as per ICH guidelines. Release data were examined kinetically. SD with 1:4 and 1:5 ratio of drug to polymer obtained by solvent evaporation and cogrinding were selected as the best candidates suitable for prolonged-release oral dosage form of metformin.

No MeSH data available.