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Formulation and evaluation of extended-release solid dispersion of metformin hydrochloride.

Patil S, Kuchekar B, Chabukswar A, Jagdale S - J Young Pharm (2010)

Bottom Line: The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method.The optimized formulation was subjected to accelerated stability testing as per ICH guidelines.SD with 1:4 and 1:5 ratio of drug to polymer obtained by solvent evaporation and cogrinding were selected as the best candidates suitable for prolonged-release oral dosage form of metformin.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, MAEER's Maharashtra Institute of Pharmacy, Pune - 411 038, Maharashtra, India.

ABSTRACT
The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calorimetry and X-ray powder diffractometry. The optimized formulation was subjected to accelerated stability testing as per ICH guidelines. Release data were examined kinetically. SD with 1:4 and 1:5 ratio of drug to polymer obtained by solvent evaporation and cogrinding were selected as the best candidates suitable for prolonged-release oral dosage form of metformin.

No MeSH data available.


Dissolution profile of metformin hydrochloride, physical mixture and solid dispersions by the cogrinding method
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Figure 0002: Dissolution profile of metformin hydrochloride, physical mixture and solid dispersions by the cogrinding method

Mentions: The dissolution profiles of MET SDs along with physical mixture in DDW are shown in Figures 1 and 2 for solvent evaporation and cogrinding, respectively. MET completely dissolved within a few minutes, reflecting its high aqueous solubility. The dissolution from the physical mixture showed approximately the same behavior of pure MET, with only a very slight initial slowing down of the drug dissolution rate due to the presence of the hydrophilic HPMC, which reduces the drug wettability.


Formulation and evaluation of extended-release solid dispersion of metformin hydrochloride.

Patil S, Kuchekar B, Chabukswar A, Jagdale S - J Young Pharm (2010)

Dissolution profile of metformin hydrochloride, physical mixture and solid dispersions by the cogrinding method
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3021685&req=5

Figure 0002: Dissolution profile of metformin hydrochloride, physical mixture and solid dispersions by the cogrinding method
Mentions: The dissolution profiles of MET SDs along with physical mixture in DDW are shown in Figures 1 and 2 for solvent evaporation and cogrinding, respectively. MET completely dissolved within a few minutes, reflecting its high aqueous solubility. The dissolution from the physical mixture showed approximately the same behavior of pure MET, with only a very slight initial slowing down of the drug dissolution rate due to the presence of the hydrophilic HPMC, which reduces the drug wettability.

Bottom Line: The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method.The optimized formulation was subjected to accelerated stability testing as per ICH guidelines.SD with 1:4 and 1:5 ratio of drug to polymer obtained by solvent evaporation and cogrinding were selected as the best candidates suitable for prolonged-release oral dosage form of metformin.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, MAEER's Maharashtra Institute of Pharmacy, Pune - 411 038, Maharashtra, India.

ABSTRACT
The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calorimetry and X-ray powder diffractometry. The optimized formulation was subjected to accelerated stability testing as per ICH guidelines. Release data were examined kinetically. SD with 1:4 and 1:5 ratio of drug to polymer obtained by solvent evaporation and cogrinding were selected as the best candidates suitable for prolonged-release oral dosage form of metformin.

No MeSH data available.