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The effect of Helicobacter pylori treatment on remission of idiopathic central serous chorioretinopathy.

Rahbani-Nobar MB, Javadzadeh A, Ghojazadeh L, Rafeey M, Ghorbanihaghjo A - Mol. Vis. (2011)

Bottom Line: The difference between mean visual acuity at the end of 16 weeks and the time of subretinal fluid reabsorption was compared between the two groups.After 16 weeks, mean visual acuity improved to 0.003±0.01 (logMAR) in the treatment group and 0.004±0.02 (logMAR) in the control group.This improvement did not represent a statistically significant difference (p=0.97).

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tabriz University of Medical Sciences, Tabriz, Iran.

ABSTRACT

Purpose: The aim of this study was to evaluate the effect of Helicobacter pylori (H. pylori) treatment on remission of idiopathic central serous chorioretinopathy.

Methods: Twenty-five patients with idiopathic central serous chorioretinopathy (ICSCR) who were infected with H. pylori were treated with an anti-H. pylori treatment; another twenty-five patients with the same clinical presentations served as the control. Baseline examination and follow up visits at 2, 4, 6, 8, 12, and 16 weeks after the onset of treatment included visual acuity testing and subretinal fluid measurement. The difference between mean visual acuity at the end of 16 weeks and the time of subretinal fluid reabsorption was compared between the two groups.

Results: Subretinal fluid reabsorption time was 9.28±3.20 weeks in the treatment group and 11.63±3.18 weeks in the control group, which was statistically significant (p=0.015). After 16 weeks, mean visual acuity improved to 0.003±0.01 (logMAR) in the treatment group and 0.004±0.02 (logMAR) in the control group. This improvement did not represent a statistically significant difference (p=0.97).

Conclusions: An anti-H. pylori treatment regimen is effective in the treatment of idiopathic central serous chorioretinopathy patients and anti-H. pylori treatment can provoke the faster reabsorption of subretinal fluid.

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Related in: MedlinePlus

The trend of subretinal fluid reduction measured by optical coherence tomography at baseline and follow up visits at 2, 4, 6, 8, 12, and 16 weeks after the onset of treatment. The sample size was 25 cases for treatment group and 25 cases for control group throughout the study.
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f1: The trend of subretinal fluid reduction measured by optical coherence tomography at baseline and follow up visits at 2, 4, 6, 8, 12, and 16 weeks after the onset of treatment. The sample size was 25 cases for treatment group and 25 cases for control group throughout the study.

Mentions: Average neuroretinal and/or pigment epithelial detachment at baseline was 305.45±161.48 µm in the treatment group and 290.00±164.38 µm in the control group. The differences at baseline were not statistically significant (p=0.73); the subretinal fluid reduction trend is presented in Figure 1 and Table 1. The subretinal fluid reabsorption time was 9.28±3.20 weeks in the treatment group and 11.63±3.18 weeks in the control group, which was statistically significant (p=0.015). The Weibull survival model showed that the time of response to medication was statistically different between the two groups (p=0.04); in the treatment group, subretinal fluid reached zero earlier than the control group. Laser therapy was performed due to persistent subretinal fluid in 3 control group patients and 1 treatment group patient (Table 2).


The effect of Helicobacter pylori treatment on remission of idiopathic central serous chorioretinopathy.

Rahbani-Nobar MB, Javadzadeh A, Ghojazadeh L, Rafeey M, Ghorbanihaghjo A - Mol. Vis. (2011)

The trend of subretinal fluid reduction measured by optical coherence tomography at baseline and follow up visits at 2, 4, 6, 8, 12, and 16 weeks after the onset of treatment. The sample size was 25 cases for treatment group and 25 cases for control group throughout the study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3021578&req=5

f1: The trend of subretinal fluid reduction measured by optical coherence tomography at baseline and follow up visits at 2, 4, 6, 8, 12, and 16 weeks after the onset of treatment. The sample size was 25 cases for treatment group and 25 cases for control group throughout the study.
Mentions: Average neuroretinal and/or pigment epithelial detachment at baseline was 305.45±161.48 µm in the treatment group and 290.00±164.38 µm in the control group. The differences at baseline were not statistically significant (p=0.73); the subretinal fluid reduction trend is presented in Figure 1 and Table 1. The subretinal fluid reabsorption time was 9.28±3.20 weeks in the treatment group and 11.63±3.18 weeks in the control group, which was statistically significant (p=0.015). The Weibull survival model showed that the time of response to medication was statistically different between the two groups (p=0.04); in the treatment group, subretinal fluid reached zero earlier than the control group. Laser therapy was performed due to persistent subretinal fluid in 3 control group patients and 1 treatment group patient (Table 2).

Bottom Line: The difference between mean visual acuity at the end of 16 weeks and the time of subretinal fluid reabsorption was compared between the two groups.After 16 weeks, mean visual acuity improved to 0.003±0.01 (logMAR) in the treatment group and 0.004±0.02 (logMAR) in the control group.This improvement did not represent a statistically significant difference (p=0.97).

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tabriz University of Medical Sciences, Tabriz, Iran.

ABSTRACT

Purpose: The aim of this study was to evaluate the effect of Helicobacter pylori (H. pylori) treatment on remission of idiopathic central serous chorioretinopathy.

Methods: Twenty-five patients with idiopathic central serous chorioretinopathy (ICSCR) who were infected with H. pylori were treated with an anti-H. pylori treatment; another twenty-five patients with the same clinical presentations served as the control. Baseline examination and follow up visits at 2, 4, 6, 8, 12, and 16 weeks after the onset of treatment included visual acuity testing and subretinal fluid measurement. The difference between mean visual acuity at the end of 16 weeks and the time of subretinal fluid reabsorption was compared between the two groups.

Results: Subretinal fluid reabsorption time was 9.28±3.20 weeks in the treatment group and 11.63±3.18 weeks in the control group, which was statistically significant (p=0.015). After 16 weeks, mean visual acuity improved to 0.003±0.01 (logMAR) in the treatment group and 0.004±0.02 (logMAR) in the control group. This improvement did not represent a statistically significant difference (p=0.97).

Conclusions: An anti-H. pylori treatment regimen is effective in the treatment of idiopathic central serous chorioretinopathy patients and anti-H. pylori treatment can provoke the faster reabsorption of subretinal fluid.

Show MeSH
Related in: MedlinePlus