Limits...
Photodynamic therapy of early stage oral cavity and oropharynx neoplasms: an outcome analysis of 170 patients.

Karakullukcu B, van Oudenaarde K, Copper MP, Klop WM, van Veen R, Wildeman M, Bing Tan I - Eur Arch Otorhinolaryngol (2010)

Bottom Line: Subgroup analysis identified oral tongue, floor of mouth sites with more favorable outcome.PDT has more favorable results with certain subsites and with previously untreated lesions.However, PDT can find its place for treating lesions in previously treated areas with acceptable results.

View Article: PubMed Central - PubMed

Affiliation: Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. b.karakullukcu@nki.nl

ABSTRACT
The indications of photodynamic therapy (PDT) of oral cavity and oropharynx neoplasms are not well defined. The main reason is that the success rates are not well established. The current paper analyzes our institutional experience of early stage oral cavity and oropharynx neoplasms (Tis-T2) to identify the success rates for each subgroup according to T stage, primary or non-primary treatment and subsites. In total, 170 patients with 226 lesions are treated with PDT. From these lesions, 95 are primary neoplasms, 131 were non-primaries (recurrences and multiple primaries). The overall response rate is 90.7% with a complete response rate of 70.8%. Subgroup analysis identified oral tongue, floor of mouth sites with more favorable outcome. PDT has more favorable results with certain subsites and with previously untreated lesions. However, PDT can find its place for treating lesions in previously treated areas with acceptable results.

Show MeSH

Related in: MedlinePlus

Local disease-free interval per T stage of neoplasms
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3021196&req=5

Fig1: Local disease-free interval per T stage of neoplasms

Mentions: Tis lesions have an OR rate of 94.5% (95% CI 86.6–98.5%), with a CR rate of 79.5% (95% CI 68.4–88.0%); T1 neoplasms have an OR rate of 90.9% (95% CI 84.3–95.4%) with a CR rate of 68.6% (95% CI 59.5–76.7%); and for the T2 neoplasms, the OR rate is 81.3% (95% CI 63.6–92.8%) with a CR of 59.4% (95% CI 40.7–76.3%). The variations in tumor response between the stages are only statistically significant for Tis versus T2 stage tumors (P < 0.05). The mean local disease-free interval is 65.7 months (95% CI 49.3–82.2 months) for the Tis group, 109.1 months (95% CI 93.1–125.0 months) for T1 and 113.4 months (95% CI 81.9–144.9 months) for T2 (Fig. 1). The mean survival time is 92.2 months (95% CI 79.3–105.0 months) for dys/CIS, 98.4 months (95% CI 84.6–112.2 months) for T1 and 78.7 months (95% CI 54.2–103.2 months) for T2 tumors.Fig. 1


Photodynamic therapy of early stage oral cavity and oropharynx neoplasms: an outcome analysis of 170 patients.

Karakullukcu B, van Oudenaarde K, Copper MP, Klop WM, van Veen R, Wildeman M, Bing Tan I - Eur Arch Otorhinolaryngol (2010)

Local disease-free interval per T stage of neoplasms
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3021196&req=5

Fig1: Local disease-free interval per T stage of neoplasms
Mentions: Tis lesions have an OR rate of 94.5% (95% CI 86.6–98.5%), with a CR rate of 79.5% (95% CI 68.4–88.0%); T1 neoplasms have an OR rate of 90.9% (95% CI 84.3–95.4%) with a CR rate of 68.6% (95% CI 59.5–76.7%); and for the T2 neoplasms, the OR rate is 81.3% (95% CI 63.6–92.8%) with a CR of 59.4% (95% CI 40.7–76.3%). The variations in tumor response between the stages are only statistically significant for Tis versus T2 stage tumors (P < 0.05). The mean local disease-free interval is 65.7 months (95% CI 49.3–82.2 months) for the Tis group, 109.1 months (95% CI 93.1–125.0 months) for T1 and 113.4 months (95% CI 81.9–144.9 months) for T2 (Fig. 1). The mean survival time is 92.2 months (95% CI 79.3–105.0 months) for dys/CIS, 98.4 months (95% CI 84.6–112.2 months) for T1 and 78.7 months (95% CI 54.2–103.2 months) for T2 tumors.Fig. 1

Bottom Line: Subgroup analysis identified oral tongue, floor of mouth sites with more favorable outcome.PDT has more favorable results with certain subsites and with previously untreated lesions.However, PDT can find its place for treating lesions in previously treated areas with acceptable results.

View Article: PubMed Central - PubMed

Affiliation: Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. b.karakullukcu@nki.nl

ABSTRACT
The indications of photodynamic therapy (PDT) of oral cavity and oropharynx neoplasms are not well defined. The main reason is that the success rates are not well established. The current paper analyzes our institutional experience of early stage oral cavity and oropharynx neoplasms (Tis-T2) to identify the success rates for each subgroup according to T stage, primary or non-primary treatment and subsites. In total, 170 patients with 226 lesions are treated with PDT. From these lesions, 95 are primary neoplasms, 131 were non-primaries (recurrences and multiple primaries). The overall response rate is 90.7% with a complete response rate of 70.8%. Subgroup analysis identified oral tongue, floor of mouth sites with more favorable outcome. PDT has more favorable results with certain subsites and with previously untreated lesions. However, PDT can find its place for treating lesions in previously treated areas with acceptable results.

Show MeSH
Related in: MedlinePlus