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Molecular mechanisms of glucocorticoids action: implications for treatment of rhinosinusitis and nasal polyposis.

Grzanka A, Misiołek M, Golusiński W, Jarząb J - Eur Arch Otorhinolaryngol (2010)

Bottom Line: Their effectiveness depends on many factors and not all of them have been well recognized so far.The authors present the basic information on molecular mechanisms of glucocorticoid action, direct and indirect effects of glucocorticoids on transcription of genes encoding inflammatory mediators.They focus on recently proved nongenomic mechanisms which appear quickly, from several seconds to minutes after glucocorticoid administration and discuss clinical implications resulting from this knowledge.

View Article: PubMed Central - PubMed

Affiliation: Clinical Department of Internal Diseases, Dermatology and Allergology, Zabrze, Medical University of Silesia, M.C.Skłodowskiej 10, 41-800 Katowice, Poland. alicjag@mp.pl

ABSTRACT
Intra-nasal glucocorticoids are the most effective drugs available for rhinosinusitis and nasal polyposis treatment. Their effectiveness depends on many factors and not all of them have been well recognized so far. The authors present the basic information on molecular mechanisms of glucocorticoid action, direct and indirect effects of glucocorticoids on transcription of genes encoding inflammatory mediators. They focus on recently proved nongenomic mechanisms which appear quickly, from several seconds to minutes after glucocorticoid administration and discuss clinical implications resulting from this knowledge. Discovery of nongenomic glucocorticoid actions allows for better use of these drugs in clinical practice.

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Related in: MedlinePlus

Intracellular localization of glucocorticoid receptor (plasma membrane, cytoplasm and nucleus) and nongenomic and genomic mechanism of glucocorticoids actions
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Fig1: Intracellular localization of glucocorticoid receptor (plasma membrane, cytoplasm and nucleus) and nongenomic and genomic mechanism of glucocorticoids actions

Mentions: The unusually wide range of GC actions can be explained by GCR presence in three cell compartments: nucleus, cytoplasm, and plasma membrane (Fig. 1).Fig. 1


Molecular mechanisms of glucocorticoids action: implications for treatment of rhinosinusitis and nasal polyposis.

Grzanka A, Misiołek M, Golusiński W, Jarząb J - Eur Arch Otorhinolaryngol (2010)

Intracellular localization of glucocorticoid receptor (plasma membrane, cytoplasm and nucleus) and nongenomic and genomic mechanism of glucocorticoids actions
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3021186&req=5

Fig1: Intracellular localization of glucocorticoid receptor (plasma membrane, cytoplasm and nucleus) and nongenomic and genomic mechanism of glucocorticoids actions
Mentions: The unusually wide range of GC actions can be explained by GCR presence in three cell compartments: nucleus, cytoplasm, and plasma membrane (Fig. 1).Fig. 1

Bottom Line: Their effectiveness depends on many factors and not all of them have been well recognized so far.The authors present the basic information on molecular mechanisms of glucocorticoid action, direct and indirect effects of glucocorticoids on transcription of genes encoding inflammatory mediators.They focus on recently proved nongenomic mechanisms which appear quickly, from several seconds to minutes after glucocorticoid administration and discuss clinical implications resulting from this knowledge.

View Article: PubMed Central - PubMed

Affiliation: Clinical Department of Internal Diseases, Dermatology and Allergology, Zabrze, Medical University of Silesia, M.C.Skłodowskiej 10, 41-800 Katowice, Poland. alicjag@mp.pl

ABSTRACT
Intra-nasal glucocorticoids are the most effective drugs available for rhinosinusitis and nasal polyposis treatment. Their effectiveness depends on many factors and not all of them have been well recognized so far. The authors present the basic information on molecular mechanisms of glucocorticoid action, direct and indirect effects of glucocorticoids on transcription of genes encoding inflammatory mediators. They focus on recently proved nongenomic mechanisms which appear quickly, from several seconds to minutes after glucocorticoid administration and discuss clinical implications resulting from this knowledge. Discovery of nongenomic glucocorticoid actions allows for better use of these drugs in clinical practice.

Show MeSH
Related in: MedlinePlus