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Corynebacterium mucifaciens in an immunocompetent patient with cavitary pneumonia.

Djossou F, Bézian MC, Moynet D, Le Flèche-Matéos A, Malvy D - BMC Infect. Dis. (2010)

Bottom Line: Corynebacterium mucifaciens has been mainly isolated from skin, blood and from other normally-sterile body fluids.It has rarely been described as a human pathogen since its description.C. mucifaciens should be considered as important human pathogen in patients with severe illness and compatible history of exposure even in individuals with no clearly identified immunosuppression.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Tropical Medicine and Imported Diseases, Department of Internal Medicine and Tropical Diseases, Hôpital St-André, University Hospital Center, 1 Rue Jean-Burguet, Bordeaux F-33075, France.

ABSTRACT

Background: Corynebacterium mucifaciens has been mainly isolated from skin, blood and from other normally-sterile body fluids. It has rarely been described as a human pathogen since its description.

Case presentation: We herein report the first case of cavitary pneumonia due to C. mucifaciens in an immunocompetent man returning from Maghreb.

Conclusion: C. mucifaciens should be considered as important human pathogen in patients with severe illness and compatible history of exposure even in individuals with no clearly identified immunosuppression.

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Related in: MedlinePlus

Phylogenetic tree of 16 S rRNA gene sequences of isolate 001199 and representative Corynebacterium species, constructed by using the Neighbour-joining method. Genbank accession numbers are given in parentheses.
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Figure 3: Phylogenetic tree of 16 S rRNA gene sequences of isolate 001199 and representative Corynebacterium species, constructed by using the Neighbour-joining method. Genbank accession numbers are given in parentheses.

Mentions: On this behalf, the numerical code 001199 was given to the isolate and complete sequence analysis of the 16 S rRNA gene from the isolate was carried out as described previously [4,5]. A total of 1,208 continuous nucleotides were determined. Sequence of isolate 001199 (GenBank accession no. HQ337895) was compared to all bacterial sequences available from the GenBank database by using the BLAST program http://www.ncbi.nlm.nih.gov/blast/Blast.cgi and the MegAlign module of the Lasergene software (DNASTAR). A phylogenetic tree was generated by using the neighbour-joining algorithm [6] (Figure 3). Our isolate was found to 0.8% of divergence with the type strains of C. mucifaciens. Thus, isolate 001199 was definitely identified to belong to the species Corynebacterium mucifaciens.


Corynebacterium mucifaciens in an immunocompetent patient with cavitary pneumonia.

Djossou F, Bézian MC, Moynet D, Le Flèche-Matéos A, Malvy D - BMC Infect. Dis. (2010)

Phylogenetic tree of 16 S rRNA gene sequences of isolate 001199 and representative Corynebacterium species, constructed by using the Neighbour-joining method. Genbank accession numbers are given in parentheses.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3009641&req=5

Figure 3: Phylogenetic tree of 16 S rRNA gene sequences of isolate 001199 and representative Corynebacterium species, constructed by using the Neighbour-joining method. Genbank accession numbers are given in parentheses.
Mentions: On this behalf, the numerical code 001199 was given to the isolate and complete sequence analysis of the 16 S rRNA gene from the isolate was carried out as described previously [4,5]. A total of 1,208 continuous nucleotides were determined. Sequence of isolate 001199 (GenBank accession no. HQ337895) was compared to all bacterial sequences available from the GenBank database by using the BLAST program http://www.ncbi.nlm.nih.gov/blast/Blast.cgi and the MegAlign module of the Lasergene software (DNASTAR). A phylogenetic tree was generated by using the neighbour-joining algorithm [6] (Figure 3). Our isolate was found to 0.8% of divergence with the type strains of C. mucifaciens. Thus, isolate 001199 was definitely identified to belong to the species Corynebacterium mucifaciens.

Bottom Line: Corynebacterium mucifaciens has been mainly isolated from skin, blood and from other normally-sterile body fluids.It has rarely been described as a human pathogen since its description.C. mucifaciens should be considered as important human pathogen in patients with severe illness and compatible history of exposure even in individuals with no clearly identified immunosuppression.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Tropical Medicine and Imported Diseases, Department of Internal Medicine and Tropical Diseases, Hôpital St-André, University Hospital Center, 1 Rue Jean-Burguet, Bordeaux F-33075, France.

ABSTRACT

Background: Corynebacterium mucifaciens has been mainly isolated from skin, blood and from other normally-sterile body fluids. It has rarely been described as a human pathogen since its description.

Case presentation: We herein report the first case of cavitary pneumonia due to C. mucifaciens in an immunocompetent man returning from Maghreb.

Conclusion: C. mucifaciens should be considered as important human pathogen in patients with severe illness and compatible history of exposure even in individuals with no clearly identified immunosuppression.

Show MeSH
Related in: MedlinePlus