Limits...
Relationship between obesity and N-terminal brain natriuretic Peptide level as a prognostic value after acute myocardial infarction.

Choi SG, Jeong MH, Ahn Y, Cho JG, Kang JC, Chae SC, Hur SH, Hong TJ, Kim YJ, Seong IW, Chae JK, Rhew JY, Chae IH, Cho MC, Bae JH, Rha SW, Kim CJ, Choi D, Jang YS, Yoon J, Chung WS, Seung KB, Park SJ, Other Korea Acute Myocardial Infarction Registry Investigato - Korean Circ J (2010)

Bottom Line: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study.These patients were divided into men (n=1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs.Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yeosu Chonnam Hospital, Yeosu, Korea.

ABSTRACT

Background and objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients.

Subjects and methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n=1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated.

Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01).

Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.

No MeSH data available.


Related in: MedlinePlus

Box-plot of NT-proBNP in patients with and without MACE. NT-proBNP was lower in patients without MACE (group I) than in patient with MACE (group II) (1,519±3,088 pg/mL vs. 2,548±4,469 pg/mL, p=0.001). NT-proBNP: N-terminal brain natriuretic peptide, MACE: major adverse cardiac events.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3008826&req=5

Figure 2: Box-plot of NT-proBNP in patients with and without MACE. NT-proBNP was lower in patients without MACE (group I) than in patient with MACE (group II) (1,519±3,088 pg/mL vs. 2,548±4,469 pg/mL, p=0.001). NT-proBNP: N-terminal brain natriuretic peptide, MACE: major adverse cardiac events.

Mentions: As analyzed by multiple regression (Table 2), significantly influencing factors of NT-proBNP were sex, creatinine level, creatine kinase-MB level, Killip clsass, MACE, age, and BMI. Table 2 demonstrates that NT-proBNP was higher in men, in older patients, with elevated creatinine levels and with lower BMIs (p<0.001 in each case). Fig. 1 shows a box-plot of NT-proBNP and Killip class. NT-proBNP was higher in the Killip class II, III, IV groups than in the Killip class I group (3,353±5,329 pg/mL vs. 1,174±2,240 pg/mL, p<0.001). Fig. 2 shows a box-plot of NT-proBNP in patients with (group II) and without (group I) MACE. NT-proBNP was higher in group II than in group I (2,548±4,469 pg/mL vs. 1,530±3,088 pg/mL, p=0.001).


Relationship between obesity and N-terminal brain natriuretic Peptide level as a prognostic value after acute myocardial infarction.

Choi SG, Jeong MH, Ahn Y, Cho JG, Kang JC, Chae SC, Hur SH, Hong TJ, Kim YJ, Seong IW, Chae JK, Rhew JY, Chae IH, Cho MC, Bae JH, Rha SW, Kim CJ, Choi D, Jang YS, Yoon J, Chung WS, Seung KB, Park SJ, Other Korea Acute Myocardial Infarction Registry Investigato - Korean Circ J (2010)

Box-plot of NT-proBNP in patients with and without MACE. NT-proBNP was lower in patients without MACE (group I) than in patient with MACE (group II) (1,519±3,088 pg/mL vs. 2,548±4,469 pg/mL, p=0.001). NT-proBNP: N-terminal brain natriuretic peptide, MACE: major adverse cardiac events.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3008826&req=5

Figure 2: Box-plot of NT-proBNP in patients with and without MACE. NT-proBNP was lower in patients without MACE (group I) than in patient with MACE (group II) (1,519±3,088 pg/mL vs. 2,548±4,469 pg/mL, p=0.001). NT-proBNP: N-terminal brain natriuretic peptide, MACE: major adverse cardiac events.
Mentions: As analyzed by multiple regression (Table 2), significantly influencing factors of NT-proBNP were sex, creatinine level, creatine kinase-MB level, Killip clsass, MACE, age, and BMI. Table 2 demonstrates that NT-proBNP was higher in men, in older patients, with elevated creatinine levels and with lower BMIs (p<0.001 in each case). Fig. 1 shows a box-plot of NT-proBNP and Killip class. NT-proBNP was higher in the Killip class II, III, IV groups than in the Killip class I group (3,353±5,329 pg/mL vs. 1,174±2,240 pg/mL, p<0.001). Fig. 2 shows a box-plot of NT-proBNP in patients with (group II) and without (group I) MACE. NT-proBNP was higher in group II than in group I (2,548±4,469 pg/mL vs. 1,530±3,088 pg/mL, p=0.001).

Bottom Line: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study.These patients were divided into men (n=1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs.Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yeosu Chonnam Hospital, Yeosu, Korea.

ABSTRACT

Background and objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients.

Subjects and methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n=1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated.

Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01).

Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.

No MeSH data available.


Related in: MedlinePlus