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Malondialdehyde suppresses cerebral function by breaking homeostasis between excitation and inhibition in turtle Trachemys scripta.

Li F, Yang Z, Lu Y, Wei Y, Wang J, Yin D, He R - PLoS ONE (2010)

Bottom Line: These changes were found associated with the deterioration of encoding action potentials in cortical neurons.In addition, MDA increased the ratio of γ-aminobutyric acid to glutamate in turtle's brain, as well as the sensitivity of GABAergic neurons to inputs compared to excitatory neurons.Therefore, MDA, as a metabolic product in the brain, may weaken cerebral function during carbonyl stress through breaking the homeostasis between excitatory and inhibitory neurons.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

ABSTRACT
The levels of malondialdehyde (MDA) are high in the brain during carbonyl stress, such as following daily activities and sleep deprivation. To examine our hypothesis that MDA is one of the major substances in the brain leading to fatigue, the influences of MDA on brain functions and neuronal encodings in red-eared turtle (Trachemys scripta) were studied. The intrathecal injections of MDA brought about sleep-like EEG and fatigue-like behaviors in a dose-dependent manner. These changes were found associated with the deterioration of encoding action potentials in cortical neurons. In addition, MDA increased the ratio of γ-aminobutyric acid to glutamate in turtle's brain, as well as the sensitivity of GABAergic neurons to inputs compared to excitatory neurons. Therefore, MDA, as a metabolic product in the brain, may weaken cerebral function during carbonyl stress through breaking the homeostasis between excitatory and inhibitory neurons.

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Related in: MedlinePlus

Effects of different concentrations of MDA on the EEG signals of turtles.Typical EEG spectra of turtles treated with different concentrations of MDA (0.1 ml/kg body weight) at different time intervals were as indicated. The EEG signals of turtles without MDA treatment were used as control.
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pone-0015325-g001: Effects of different concentrations of MDA on the EEG signals of turtles.Typical EEG spectra of turtles treated with different concentrations of MDA (0.1 ml/kg body weight) at different time intervals were as indicated. The EEG signals of turtles without MDA treatment were used as control.

Mentions: Before MDA treatment, the turtles' heads lifted, and their eyes opened. They occasionally moved their heads and legs, with intense muscular activities. The threshold for the reaction to stimuli was low, showing a quick retraction of heads and legs into the shell. Under this condition, the EEG was characterized by a pattern of high frequency and low amplitude (control in Fig. 1).


Malondialdehyde suppresses cerebral function by breaking homeostasis between excitation and inhibition in turtle Trachemys scripta.

Li F, Yang Z, Lu Y, Wei Y, Wang J, Yin D, He R - PLoS ONE (2010)

Effects of different concentrations of MDA on the EEG signals of turtles.Typical EEG spectra of turtles treated with different concentrations of MDA (0.1 ml/kg body weight) at different time intervals were as indicated. The EEG signals of turtles without MDA treatment were used as control.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3008675&req=5

pone-0015325-g001: Effects of different concentrations of MDA on the EEG signals of turtles.Typical EEG spectra of turtles treated with different concentrations of MDA (0.1 ml/kg body weight) at different time intervals were as indicated. The EEG signals of turtles without MDA treatment were used as control.
Mentions: Before MDA treatment, the turtles' heads lifted, and their eyes opened. They occasionally moved their heads and legs, with intense muscular activities. The threshold for the reaction to stimuli was low, showing a quick retraction of heads and legs into the shell. Under this condition, the EEG was characterized by a pattern of high frequency and low amplitude (control in Fig. 1).

Bottom Line: These changes were found associated with the deterioration of encoding action potentials in cortical neurons.In addition, MDA increased the ratio of γ-aminobutyric acid to glutamate in turtle's brain, as well as the sensitivity of GABAergic neurons to inputs compared to excitatory neurons.Therefore, MDA, as a metabolic product in the brain, may weaken cerebral function during carbonyl stress through breaking the homeostasis between excitatory and inhibitory neurons.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

ABSTRACT
The levels of malondialdehyde (MDA) are high in the brain during carbonyl stress, such as following daily activities and sleep deprivation. To examine our hypothesis that MDA is one of the major substances in the brain leading to fatigue, the influences of MDA on brain functions and neuronal encodings in red-eared turtle (Trachemys scripta) were studied. The intrathecal injections of MDA brought about sleep-like EEG and fatigue-like behaviors in a dose-dependent manner. These changes were found associated with the deterioration of encoding action potentials in cortical neurons. In addition, MDA increased the ratio of γ-aminobutyric acid to glutamate in turtle's brain, as well as the sensitivity of GABAergic neurons to inputs compared to excitatory neurons. Therefore, MDA, as a metabolic product in the brain, may weaken cerebral function during carbonyl stress through breaking the homeostasis between excitatory and inhibitory neurons.

Show MeSH
Related in: MedlinePlus