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An unusual case of localised hypertrichosis.

McCourt C, Hoey S - Ulster Med J (2010)

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It is well reported that transcutaneous absorption of testosterone may lead to hirsuitism and virilisation., We report an interesting case of localised hypertrichosis on the forearm of a female patient and postulate that this was the result of accidental transfer of testosterone gel from the patients' husband... A 66-year old lady presented with a one-year history of localised hair growth on the right forearm... This was applied daily for hypoandrogenism, secondary to radiation therapy for multiple myeloma... On examination she had localised hypertrichosis on the right forearm, sparing the right dorsal hand, associated with an eczematous eruption. (Fig.1) There were no other relevant clinical findings... This was felt to be secondary to transfer of testosterone gel from her partner during contact, because her hair growth and testosterone levels returned to normal after her partner switched to injectable testosterone... Not all cases are associated with hyperandrogenism however... In one case series of two females applying testosterone gel for treatment of lichen sclerosus et atrophicus, both developed hirsuitism two months later... Hormonal profiles were normal in both cases, however, the gel had been discontinued several weeks before presentation... Localised hypertrichosis is another known side effect of topical testosterone gel... In a recently published study looking at the effect of transdermal testosterone in female patients, the investigators found that the commonest side effect was dose-related hypertrichosis, predominatly at the delivery site... Regarding the onset of hirsuitism and virilisation with testosterone, time to development varies between reports, most cases presenting between 8-72 months of use and resolving within 2-12 months... This interesting case highlights the importance of a thorough history in a patient presenting with hirsuitism, hypertrichosis or virilisation, particularly when the pattern of hair growth is unusual in the presence of normal hormonal investigations.

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Mentions: On examination she had localised hypertrichosis on the right forearm, sparing the right dorsal hand, associated with an eczematous eruption. (Fig.1) There were no other relevant clinical findings. Hormone profile including free testosterone was normal. In view of the temporal relationship between application of the gel and the findings of localised hypertrichosis with a normal hormone profile, we feel that the intermittent application of testogel ® was the causative factor.


An unusual case of localised hypertrichosis.

McCourt C, Hoey S - Ulster Med J (2010)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2993147&req=5

Mentions: On examination she had localised hypertrichosis on the right forearm, sparing the right dorsal hand, associated with an eczematous eruption. (Fig.1) There were no other relevant clinical findings. Hormone profile including free testosterone was normal. In view of the temporal relationship between application of the gel and the findings of localised hypertrichosis with a normal hormone profile, we feel that the intermittent application of testogel ® was the causative factor.

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

It is well reported that transcutaneous absorption of testosterone may lead to hirsuitism and virilisation., We report an interesting case of localised hypertrichosis on the forearm of a female patient and postulate that this was the result of accidental transfer of testosterone gel from the patients' husband... A 66-year old lady presented with a one-year history of localised hair growth on the right forearm... This was applied daily for hypoandrogenism, secondary to radiation therapy for multiple myeloma... On examination she had localised hypertrichosis on the right forearm, sparing the right dorsal hand, associated with an eczematous eruption. (Fig.1) There were no other relevant clinical findings... This was felt to be secondary to transfer of testosterone gel from her partner during contact, because her hair growth and testosterone levels returned to normal after her partner switched to injectable testosterone... Not all cases are associated with hyperandrogenism however... In one case series of two females applying testosterone gel for treatment of lichen sclerosus et atrophicus, both developed hirsuitism two months later... Hormonal profiles were normal in both cases, however, the gel had been discontinued several weeks before presentation... Localised hypertrichosis is another known side effect of topical testosterone gel... In a recently published study looking at the effect of transdermal testosterone in female patients, the investigators found that the commonest side effect was dose-related hypertrichosis, predominatly at the delivery site... Regarding the onset of hirsuitism and virilisation with testosterone, time to development varies between reports, most cases presenting between 8-72 months of use and resolving within 2-12 months... This interesting case highlights the importance of a thorough history in a patient presenting with hirsuitism, hypertrichosis or virilisation, particularly when the pattern of hair growth is unusual in the presence of normal hormonal investigations.

Show MeSH