Limits...
Marine antitumor drugs: status, shortfalls and strategies.

Bhatnagar I, Kim SK - Mar Drugs (2010)

Bottom Line: However, the marine environment has been less explored for the production of safe and novel antitumor compounds.The reason is a number of shortfalls in this field.In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Pukyong National University, Busan 608-737, Korea. ibhatnagar@gmail.com

ABSTRACT
Cancer is considered as one of the deadliest diseases in the medical field. Apart from the preventive therapies, it is important to find a curative measure which holds no loopholes and acts accurately and precisely to curb cancer. Over the past few decades, there have been advances in this field and there are many antitumor compounds available on the market, which are of natural as well as synthetic origin. Marine chemotherapy is well recognized nowadays and profound development has been achieved by researchers to deal with different molecular pathways of tumors. However, the marine environment has been less explored for the production of safe and novel antitumor compounds. The reason is a number of shortfalls in this field. Though ample reviews cover the importance and applications of various anticancerous compounds from marine natural products, in the present review, we have tried to bring the current status of antitumor research based on marine inhibitors of cancer signaling pathways. In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

Show MeSH

Related in: MedlinePlus

Schematic representation of the mode of action of Topoisomerase inhibitors by (A) preventing covalent bond formation or (B) preventing DNA resealing. Here,  represents Topoisomerase enzyme and  represents Topoisomerase inhibitor.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC2993001&req=5

f3-marinedrugs-08-02702: Schematic representation of the mode of action of Topoisomerase inhibitors by (A) preventing covalent bond formation or (B) preventing DNA resealing. Here, represents Topoisomerase enzyme and represents Topoisomerase inhibitor.

Mentions: Topoisomerases play a major role in maintaining the integrity of the DNA helix during replication, transcription, and chromosome condensation in mitosis [53] and thus are important for cell proliferation. They are now being targeted for anticancer therapy. Over the past three decades, numerous topoisomerase inhibitors have been isolated from various natural sources, in order to find an effective anticancer drug. These agents either prevent the formation of covalent bonds between topoisomerase and DNA or stabilize the intermediate topoisomerase-DNA covalent binary complex thus preventing DNA relegation. They preclude DNA replication and transcription, and thereby lead to the death of cells attempting to undergo these processes (Figure 3).


Marine antitumor drugs: status, shortfalls and strategies.

Bhatnagar I, Kim SK - Mar Drugs (2010)

Schematic representation of the mode of action of Topoisomerase inhibitors by (A) preventing covalent bond formation or (B) preventing DNA resealing. Here,  represents Topoisomerase enzyme and  represents Topoisomerase inhibitor.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2993001&req=5

f3-marinedrugs-08-02702: Schematic representation of the mode of action of Topoisomerase inhibitors by (A) preventing covalent bond formation or (B) preventing DNA resealing. Here, represents Topoisomerase enzyme and represents Topoisomerase inhibitor.
Mentions: Topoisomerases play a major role in maintaining the integrity of the DNA helix during replication, transcription, and chromosome condensation in mitosis [53] and thus are important for cell proliferation. They are now being targeted for anticancer therapy. Over the past three decades, numerous topoisomerase inhibitors have been isolated from various natural sources, in order to find an effective anticancer drug. These agents either prevent the formation of covalent bonds between topoisomerase and DNA or stabilize the intermediate topoisomerase-DNA covalent binary complex thus preventing DNA relegation. They preclude DNA replication and transcription, and thereby lead to the death of cells attempting to undergo these processes (Figure 3).

Bottom Line: However, the marine environment has been less explored for the production of safe and novel antitumor compounds.The reason is a number of shortfalls in this field.In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Pukyong National University, Busan 608-737, Korea. ibhatnagar@gmail.com

ABSTRACT
Cancer is considered as one of the deadliest diseases in the medical field. Apart from the preventive therapies, it is important to find a curative measure which holds no loopholes and acts accurately and precisely to curb cancer. Over the past few decades, there have been advances in this field and there are many antitumor compounds available on the market, which are of natural as well as synthetic origin. Marine chemotherapy is well recognized nowadays and profound development has been achieved by researchers to deal with different molecular pathways of tumors. However, the marine environment has been less explored for the production of safe and novel antitumor compounds. The reason is a number of shortfalls in this field. Though ample reviews cover the importance and applications of various anticancerous compounds from marine natural products, in the present review, we have tried to bring the current status of antitumor research based on marine inhibitors of cancer signaling pathways. In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

Show MeSH
Related in: MedlinePlus