Limits...
Marine antitumor drugs: status, shortfalls and strategies.

Bhatnagar I, Kim SK - Mar Drugs (2010)

Bottom Line: However, the marine environment has been less explored for the production of safe and novel antitumor compounds.The reason is a number of shortfalls in this field.In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Pukyong National University, Busan 608-737, Korea. ibhatnagar@gmail.com

ABSTRACT
Cancer is considered as one of the deadliest diseases in the medical field. Apart from the preventive therapies, it is important to find a curative measure which holds no loopholes and acts accurately and precisely to curb cancer. Over the past few decades, there have been advances in this field and there are many antitumor compounds available on the market, which are of natural as well as synthetic origin. Marine chemotherapy is well recognized nowadays and profound development has been achieved by researchers to deal with different molecular pathways of tumors. However, the marine environment has been less explored for the production of safe and novel antitumor compounds. The reason is a number of shortfalls in this field. Though ample reviews cover the importance and applications of various anticancerous compounds from marine natural products, in the present review, we have tried to bring the current status of antitumor research based on marine inhibitors of cancer signaling pathways. In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

Show MeSH

Related in: MedlinePlus

Role of TNF-α induced NF-κB in carcinogenesis. During inflammation, TNF-α induced NF-κB acts on proliferating cells thereby causing their malfunction and leading to cancer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC2993001&req=5

f2-marinedrugs-08-02702: Role of TNF-α induced NF-κB in carcinogenesis. During inflammation, TNF-α induced NF-κB acts on proliferating cells thereby causing their malfunction and leading to cancer.

Mentions: Nuclear factor-κB (NF-κB) is a ubiquitous transcription factor, a dimer of proteins of the Rel family including NF-κB1 (p50), NF-κB2 (p52), RelA (p65), RelB and c-Rel [46], whose deregulated expression may lead to cancer (Figure 2). NF-κB is activated by various stimuli, including TNF-α (tumor necrosis factor-α), interleukin-1 and lipopolysaccharide [47]. Certain fungal metabolites show promising potential as novel anti-cancer agents as they modulate the activity of NF-κB. Folmer et al. (2008) divided NF-κB inhibitors into four categories: (a) compounds targeting the IKK-dependent degradation of IkB, (b) compounds specifically interfering with the proteolytic activity of the 26S proteasome, (c) compounds interfering with the binding of NF-κB to its DNA binding site, and (d) compounds with unknown mechanisms of action [48]. Marizomib (Salinosporamide A; NPI-0052), a proteasome inhibitor isolated from a marine bacterium Salinispora tropica, has a great potential as an anticancer drug [49]. A study published last year reported three new cyclohexadepsipeptides, Arenamides (A-C) from the fermentation broth of a marine bacterial strain Salinispora arenicola. They studied the effect of Arenamides A and B on NF-κB activity with stably transfected 293/NF-κB-Luc human embryonic kidney cells induced by treatment with tumor necrosis factor (TNF). It was observed that Arenamides A and B blocked TNF-induced activation of NF-κB in a dose- and time-dependent manner [50].


Marine antitumor drugs: status, shortfalls and strategies.

Bhatnagar I, Kim SK - Mar Drugs (2010)

Role of TNF-α induced NF-κB in carcinogenesis. During inflammation, TNF-α induced NF-κB acts on proliferating cells thereby causing their malfunction and leading to cancer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2993001&req=5

f2-marinedrugs-08-02702: Role of TNF-α induced NF-κB in carcinogenesis. During inflammation, TNF-α induced NF-κB acts on proliferating cells thereby causing their malfunction and leading to cancer.
Mentions: Nuclear factor-κB (NF-κB) is a ubiquitous transcription factor, a dimer of proteins of the Rel family including NF-κB1 (p50), NF-κB2 (p52), RelA (p65), RelB and c-Rel [46], whose deregulated expression may lead to cancer (Figure 2). NF-κB is activated by various stimuli, including TNF-α (tumor necrosis factor-α), interleukin-1 and lipopolysaccharide [47]. Certain fungal metabolites show promising potential as novel anti-cancer agents as they modulate the activity of NF-κB. Folmer et al. (2008) divided NF-κB inhibitors into four categories: (a) compounds targeting the IKK-dependent degradation of IkB, (b) compounds specifically interfering with the proteolytic activity of the 26S proteasome, (c) compounds interfering with the binding of NF-κB to its DNA binding site, and (d) compounds with unknown mechanisms of action [48]. Marizomib (Salinosporamide A; NPI-0052), a proteasome inhibitor isolated from a marine bacterium Salinispora tropica, has a great potential as an anticancer drug [49]. A study published last year reported three new cyclohexadepsipeptides, Arenamides (A-C) from the fermentation broth of a marine bacterial strain Salinispora arenicola. They studied the effect of Arenamides A and B on NF-κB activity with stably transfected 293/NF-κB-Luc human embryonic kidney cells induced by treatment with tumor necrosis factor (TNF). It was observed that Arenamides A and B blocked TNF-induced activation of NF-κB in a dose- and time-dependent manner [50].

Bottom Line: However, the marine environment has been less explored for the production of safe and novel antitumor compounds.The reason is a number of shortfalls in this field.In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Pukyong National University, Busan 608-737, Korea. ibhatnagar@gmail.com

ABSTRACT
Cancer is considered as one of the deadliest diseases in the medical field. Apart from the preventive therapies, it is important to find a curative measure which holds no loopholes and acts accurately and precisely to curb cancer. Over the past few decades, there have been advances in this field and there are many antitumor compounds available on the market, which are of natural as well as synthetic origin. Marine chemotherapy is well recognized nowadays and profound development has been achieved by researchers to deal with different molecular pathways of tumors. However, the marine environment has been less explored for the production of safe and novel antitumor compounds. The reason is a number of shortfalls in this field. Though ample reviews cover the importance and applications of various anticancerous compounds from marine natural products, in the present review, we have tried to bring the current status of antitumor research based on marine inhibitors of cancer signaling pathways. In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

Show MeSH
Related in: MedlinePlus