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Marine antitumor drugs: status, shortfalls and strategies.

Bhatnagar I, Kim SK - Mar Drugs (2010)

Bottom Line: However, the marine environment has been less explored for the production of safe and novel antitumor compounds.The reason is a number of shortfalls in this field.In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Pukyong National University, Busan 608-737, Korea. ibhatnagar@gmail.com

ABSTRACT
Cancer is considered as one of the deadliest diseases in the medical field. Apart from the preventive therapies, it is important to find a curative measure which holds no loopholes and acts accurately and precisely to curb cancer. Over the past few decades, there have been advances in this field and there are many antitumor compounds available on the market, which are of natural as well as synthetic origin. Marine chemotherapy is well recognized nowadays and profound development has been achieved by researchers to deal with different molecular pathways of tumors. However, the marine environment has been less explored for the production of safe and novel antitumor compounds. The reason is a number of shortfalls in this field. Though ample reviews cover the importance and applications of various anticancerous compounds from marine natural products, in the present review, we have tried to bring the current status of antitumor research based on marine inhibitors of cancer signaling pathways. In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

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Related in: MedlinePlus

Chemical structures of some marine derived antitumor compounds. The corresponding references have been superscripted after the compound name [11–25].
© Copyright Policy - open-access
Related In: Results  -  Collection

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f1-marinedrugs-08-02702: Chemical structures of some marine derived antitumor compounds. The corresponding references have been superscripted after the compound name [11–25].

Mentions: This research was supported by Marine Bioprocess Research Center of the Marine Bio 21 center funded by the ‘Ministry of Land, Transport and Maritime’, Republic of Korea. The authors are thankful to Jayachandran Venkatesan for redrawing the chemical structures in the Figure 1.


Marine antitumor drugs: status, shortfalls and strategies.

Bhatnagar I, Kim SK - Mar Drugs (2010)

Chemical structures of some marine derived antitumor compounds. The corresponding references have been superscripted after the compound name [11–25].
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2993001&req=5

f1-marinedrugs-08-02702: Chemical structures of some marine derived antitumor compounds. The corresponding references have been superscripted after the compound name [11–25].
Mentions: This research was supported by Marine Bioprocess Research Center of the Marine Bio 21 center funded by the ‘Ministry of Land, Transport and Maritime’, Republic of Korea. The authors are thankful to Jayachandran Venkatesan for redrawing the chemical structures in the Figure 1.

Bottom Line: However, the marine environment has been less explored for the production of safe and novel antitumor compounds.The reason is a number of shortfalls in this field.In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Pukyong National University, Busan 608-737, Korea. ibhatnagar@gmail.com

ABSTRACT
Cancer is considered as one of the deadliest diseases in the medical field. Apart from the preventive therapies, it is important to find a curative measure which holds no loopholes and acts accurately and precisely to curb cancer. Over the past few decades, there have been advances in this field and there are many antitumor compounds available on the market, which are of natural as well as synthetic origin. Marine chemotherapy is well recognized nowadays and profound development has been achieved by researchers to deal with different molecular pathways of tumors. However, the marine environment has been less explored for the production of safe and novel antitumor compounds. The reason is a number of shortfalls in this field. Though ample reviews cover the importance and applications of various anticancerous compounds from marine natural products, in the present review, we have tried to bring the current status of antitumor research based on marine inhibitors of cancer signaling pathways. In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.

Show MeSH
Related in: MedlinePlus