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Antiviral lead compounds from marine sponges.

Sagar S, Kaur M, Minneman KP - Mar Drugs (2010)

Bottom Line: Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment.They are usually produced by functional enzyme clusters in sponges and/or their associated symbiotic microorganisms.Natural product lead compounds from sponges have often been found to be promising pharmaceutical agents.

View Article: PubMed Central - PubMed

Affiliation: Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Jeddah, Saudi Arabia. sunil.sagar@kaust.edu.sa

ABSTRACT
Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme clusters in sponges and/or their associated symbiotic microorganisms. Natural product lead compounds from sponges have often been found to be promising pharmaceutical agents. Several of them have successfully been approved as antiviral agents for clinical use or have been advanced to the late stages of clinical trials. Most of these drugs are used for the treatment of human immunodeficiency virus (HIV) and herpes simplex virus (HSV). The most important antiviral lead of marine origin reported thus far is nucleoside Ara-A (vidarabine) isolated from sponge Tethya crypta. It inhibits viral DNA polymerase and DNA synthesis of herpes, vaccinica and varicella zoster viruses. However due to the discovery of new types of viruses and emergence of drug resistant strains, it is necessary to develop new antiviral lead compounds continuously. Several sponge derived antiviral lead compounds which are hoped to be developed as future drugs are discussed in this review. Supply problems are usually the major bottleneck to the development of these compounds as drugs during clinical trials. However advances in the field of metagenomics and high throughput microbial cultivation has raised the possibility that these techniques could lead to the cost-effective large scale production of such compounds. Perspectives on biotechnological methods with respect to marine drug development are also discussed.

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Structures of Papuamide A, B, C and D.
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f4-marinedrugs-08-02619: Structures of Papuamide A, B, C and D.

Mentions: The anti-HIV and cytotoxic cyclic depsipeptides, papuamides, were isolated from the sponges Theonella mirabilis and Theonella swinhoei that were collected along the north coast of Papua New Guinea [53]. Two groups from the National Cancer Institute and the University of British Columbia independently reported the isolation of papuamides A and B from T. mirabilis and papuamides A, B, C, and D from T. swinhoei, respectively (Figure 4).


Antiviral lead compounds from marine sponges.

Sagar S, Kaur M, Minneman KP - Mar Drugs (2010)

Structures of Papuamide A, B, C and D.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2992996&req=5

f4-marinedrugs-08-02619: Structures of Papuamide A, B, C and D.
Mentions: The anti-HIV and cytotoxic cyclic depsipeptides, papuamides, were isolated from the sponges Theonella mirabilis and Theonella swinhoei that were collected along the north coast of Papua New Guinea [53]. Two groups from the National Cancer Institute and the University of British Columbia independently reported the isolation of papuamides A and B from T. mirabilis and papuamides A, B, C, and D from T. swinhoei, respectively (Figure 4).

Bottom Line: Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment.They are usually produced by functional enzyme clusters in sponges and/or their associated symbiotic microorganisms.Natural product lead compounds from sponges have often been found to be promising pharmaceutical agents.

View Article: PubMed Central - PubMed

Affiliation: Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Jeddah, Saudi Arabia. sunil.sagar@kaust.edu.sa

ABSTRACT
Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme clusters in sponges and/or their associated symbiotic microorganisms. Natural product lead compounds from sponges have often been found to be promising pharmaceutical agents. Several of them have successfully been approved as antiviral agents for clinical use or have been advanced to the late stages of clinical trials. Most of these drugs are used for the treatment of human immunodeficiency virus (HIV) and herpes simplex virus (HSV). The most important antiviral lead of marine origin reported thus far is nucleoside Ara-A (vidarabine) isolated from sponge Tethya crypta. It inhibits viral DNA polymerase and DNA synthesis of herpes, vaccinica and varicella zoster viruses. However due to the discovery of new types of viruses and emergence of drug resistant strains, it is necessary to develop new antiviral lead compounds continuously. Several sponge derived antiviral lead compounds which are hoped to be developed as future drugs are discussed in this review. Supply problems are usually the major bottleneck to the development of these compounds as drugs during clinical trials. However advances in the field of metagenomics and high throughput microbial cultivation has raised the possibility that these techniques could lead to the cost-effective large scale production of such compounds. Perspectives on biotechnological methods with respect to marine drug development are also discussed.

Show MeSH
Related in: MedlinePlus