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Colletotrichum graminicola keratitis: first case report from India.

Yegneswaran PP, Pai V, Bairy I, Bhandary S - Indian J Ophthalmol (2010 Sep-Oct)

Bottom Line: Colletotrichum graminicola is a medically important fungus belonging to the order Melanconiales under the class Coelomycetes.In the past few decades, they are progressively being implicated as etiological agents of subcutaneous hyalohyphomycoses and keratomycoses.The patient was treated with a combination of oral ketoconazole and topical fluconazole and natamycin.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, Kasturba Medical College, Manipal University, Manipal, India.

ABSTRACT
Colletotrichum graminicola is a medically important fungus belonging to the order Melanconiales under the class Coelomycetes. The members of the genus Colletotrichum are primarily plant pathogens which cause anthracnoses (fungal infection in plants). In the past few decades, they are progressively being implicated as etiological agents of subcutaneous hyalohyphomycoses and keratomycoses. Of the five medically important members in the genus Colletotrichum, keratitis due to Colletotrichum graminicola is rare. We diagnosed Colletotrichum graminicola keratitis in a 44-year-old man who presented with a non-healing corneal ulcer since three weeks. Positive smears and cultures from the corneal scrapings established the causative organism as C. graminicola. The patient was treated with a combination of oral ketoconazole and topical fluconazole and natamycin. Infection resolved over 10 weeks and antimicrobials were stopped. We describe the clinical presentation and treatment outcome of Colletotrichum graminicola keratitis.

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Healed ulcer with scarring at 21 weeks
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Figure 0005: Healed ulcer with scarring at 21 weeks

Mentions: Treatment was started with oral ketoconazole 200 mg twice daily (liver functions were normal) which was continued for two weeks. Fluconazole 0.3% eye drops, natamycin 5% eye drops were given hourly and atropine 1% eye drops was used thrice a day. Epithelial defect healed by six weeks and the infiltrates fully resolved by eight weeks [Fig. 5]. After 10 weeks, all medications were tapered and stopped. At 21 weeks, patient had a corneal opacity and the unaided corrected visual acuity was 20/30 and N6.


Colletotrichum graminicola keratitis: first case report from India.

Yegneswaran PP, Pai V, Bairy I, Bhandary S - Indian J Ophthalmol (2010 Sep-Oct)

Healed ulcer with scarring at 21 weeks
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2992917&req=5

Figure 0005: Healed ulcer with scarring at 21 weeks
Mentions: Treatment was started with oral ketoconazole 200 mg twice daily (liver functions were normal) which was continued for two weeks. Fluconazole 0.3% eye drops, natamycin 5% eye drops were given hourly and atropine 1% eye drops was used thrice a day. Epithelial defect healed by six weeks and the infiltrates fully resolved by eight weeks [Fig. 5]. After 10 weeks, all medications were tapered and stopped. At 21 weeks, patient had a corneal opacity and the unaided corrected visual acuity was 20/30 and N6.

Bottom Line: Colletotrichum graminicola is a medically important fungus belonging to the order Melanconiales under the class Coelomycetes.In the past few decades, they are progressively being implicated as etiological agents of subcutaneous hyalohyphomycoses and keratomycoses.The patient was treated with a combination of oral ketoconazole and topical fluconazole and natamycin.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, Kasturba Medical College, Manipal University, Manipal, India.

ABSTRACT
Colletotrichum graminicola is a medically important fungus belonging to the order Melanconiales under the class Coelomycetes. The members of the genus Colletotrichum are primarily plant pathogens which cause anthracnoses (fungal infection in plants). In the past few decades, they are progressively being implicated as etiological agents of subcutaneous hyalohyphomycoses and keratomycoses. Of the five medically important members in the genus Colletotrichum, keratitis due to Colletotrichum graminicola is rare. We diagnosed Colletotrichum graminicola keratitis in a 44-year-old man who presented with a non-healing corneal ulcer since three weeks. Positive smears and cultures from the corneal scrapings established the causative organism as C. graminicola. The patient was treated with a combination of oral ketoconazole and topical fluconazole and natamycin. Infection resolved over 10 weeks and antimicrobials were stopped. We describe the clinical presentation and treatment outcome of Colletotrichum graminicola keratitis.

Show MeSH
Related in: MedlinePlus