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Antimicrobial peptides in gastrointestinal inflammation.

Jäger S, Stange EF, Wehkamp J - Int J Inflam (2010)

Bottom Line: The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigated thoroughly over the recent years, and their involvement in various disease states is expanded ever more.In this paper, we focus on the role of antimicrobial peptides in inflammatory processes along the gastrointestinal tract, while considering the resident and pathogenic flora encountered at the specific sites.The role of antimicrobial peptides in the primary events of inflammatory bowel diseases receives special attention.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine I, Robert Bosch Hospital, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany.

ABSTRACT
Acute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigated thoroughly over the recent years, and their involvement in various disease states is expanded ever more. Especially in the intestines, a critical balance between luminal bacteria and the antimicrobial peptides is essential, and a breakdown in barrier function by impaired production of defensins is already implicated in Crohn's disease. In this paper, we focus on the role of antimicrobial peptides in inflammatory processes along the gastrointestinal tract, while considering the resident and pathogenic flora encountered at the specific sites. The role of antimicrobial peptides in the primary events of inflammatory bowel diseases receives special attention.

No MeSH data available.


Related in: MedlinePlus

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Mentions: Fittingly, despite a high expression of numerous antimicrobial peptides, assays with oesophageal tissue showed a weakened potency to kill C. albicans [30], a fact which could help explain the susceptibility of esophageal tissues to infections with this yeast. Kiehne et al. [31] observed that Candida colonization induced a high expression of a subset of antimicrobial peptides, especially hBD-2 (shown in Figure 1) and hBD-3. In a subsequent mechanistic study the group showed that polymorphonuclear leukocytes (PMNs) reinforce the defensin expression in the epithelium. The authors speculate that individuals suffering from neutropenia lack this stimulus for the expression of epithelial antimicrobial peptides and thus, a pathophysiologic explanation for the high incidence of Candida esophagitis and Candida-related deaths in neutropenic patients can be proposed [32]. Furthermore, even in esophageal reflux disease, an induction of β-defensin expression (hBD-2 and hBD-3) could be found, although to a minor degree [31].


Antimicrobial peptides in gastrointestinal inflammation.

Jäger S, Stange EF, Wehkamp J - Int J Inflam (2010)

© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2992817&req=5

Mentions: Fittingly, despite a high expression of numerous antimicrobial peptides, assays with oesophageal tissue showed a weakened potency to kill C. albicans [30], a fact which could help explain the susceptibility of esophageal tissues to infections with this yeast. Kiehne et al. [31] observed that Candida colonization induced a high expression of a subset of antimicrobial peptides, especially hBD-2 (shown in Figure 1) and hBD-3. In a subsequent mechanistic study the group showed that polymorphonuclear leukocytes (PMNs) reinforce the defensin expression in the epithelium. The authors speculate that individuals suffering from neutropenia lack this stimulus for the expression of epithelial antimicrobial peptides and thus, a pathophysiologic explanation for the high incidence of Candida esophagitis and Candida-related deaths in neutropenic patients can be proposed [32]. Furthermore, even in esophageal reflux disease, an induction of β-defensin expression (hBD-2 and hBD-3) could be found, although to a minor degree [31].

Bottom Line: The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigated thoroughly over the recent years, and their involvement in various disease states is expanded ever more.In this paper, we focus on the role of antimicrobial peptides in inflammatory processes along the gastrointestinal tract, while considering the resident and pathogenic flora encountered at the specific sites.The role of antimicrobial peptides in the primary events of inflammatory bowel diseases receives special attention.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine I, Robert Bosch Hospital, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany.

ABSTRACT
Acute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigated thoroughly over the recent years, and their involvement in various disease states is expanded ever more. Especially in the intestines, a critical balance between luminal bacteria and the antimicrobial peptides is essential, and a breakdown in barrier function by impaired production of defensins is already implicated in Crohn's disease. In this paper, we focus on the role of antimicrobial peptides in inflammatory processes along the gastrointestinal tract, while considering the resident and pathogenic flora encountered at the specific sites. The role of antimicrobial peptides in the primary events of inflammatory bowel diseases receives special attention.

No MeSH data available.


Related in: MedlinePlus