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Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children.

Wu L, Xi B, Zhang M, Shen Y, Zhao X, Cheng H, Hou D, Sun D, Ott J, Wang X, Mi J - Diabetes (2010)

Bottom Line: Childhood obesity strongly predisposes to some adult diseases.A total of 3,503 children participated in the study, including 1,229 obese, 655 overweight, and 1,619 normal-weight children (diagnosed by the Chinese age- and sex-specific BMI cutoffs).The SNPs rs17782313 and rs10938397 were also significantly associated with waist circumference, waist-to-height ratio, and fat mass percentage.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.

ABSTRACT

Objective: Childhood obesity strongly predisposes to some adult diseases. Recently, genome-wide association (GWA) studies in Caucasians identified multiple single nucleotide polymorphisms (SNPs) associated with BMI and obesity. The associations of those SNPs with BMI and obesity among other ethnicities are not fully described, especially in children. Among those previously identified SNPs, we selected six (rs7138803, rs1805081, rs6499640, rs17782313, rs6265, and rs10938397, in or near obesity-related genes FAIM2, NPC1, FTO, MC4R, BDNF, and GNPDA2, respectively) because of the relatively high minor allele frequencies in Chinese individuals and tested the associations of the SNPs with BMI and obesity in Chinese children.

Research design and methods: We investigated the associations of these SNPs with BMI and obesity in school-aged children. A total of 3,503 children participated in the study, including 1,229 obese, 655 overweight, and 1,619 normal-weight children (diagnosed by the Chinese age- and sex-specific BMI cutoffs).

Results: After age and sex adjustment and correction for multiple testing, the SNPs rs17782313, rs6265, and rs10938397 were associated with BMI (P = 1.0 × 10⁻⁵, 0.038, and 0.00093, respectively) and also obesity (P = 5.0 × 10⁻⁶, 0.043, and 0.00085, respectively) in the Chinese children. The SNPs rs17782313 and rs10938397 were also significantly associated with waist circumference, waist-to-height ratio, and fat mass percentage.

Conclusions: Results of this study support obesity-related genes in adults as important genes for BMI variation in children and suggest that some SNPs identified by GWA studies in Caucasians also confer risk for obesity in Chinese children.

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Frequency distribution of the number of effect alleles in normal-weight, overweight, and obese groups.
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Figure 1: Frequency distribution of the number of effect alleles in normal-weight, overweight, and obese groups.

Mentions: Figure 1 shows the frequency distribution of the number of effect alleles of the six SNPs in normal-weight, overweight, and obese groups. The associations of the number of effect alleles with overweight and obesity are shown in supplementary Table 7. Most subjects of each group carry four to six effect alleles. In the obese group, compared with subjects that carry three or fewer effect alleles, the risk of obesity of the subjects that carry four to six and greater than seven effect alleles was 1.54 (one-sided 95% CI >1.31; one-sided P = 5.9 × 10−6) and 2.50 (one-sided 95% CI >1.97; one-sided P = 1.3 × 10−10), respectively. There were significant associations of the number of effect alleles with anthropometric indexes (except birth weight) including BMI, waist circumference, WHtR, and FMP (supplementary Table 8).


Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children.

Wu L, Xi B, Zhang M, Shen Y, Zhao X, Cheng H, Hou D, Sun D, Ott J, Wang X, Mi J - Diabetes (2010)

Frequency distribution of the number of effect alleles in normal-weight, overweight, and obese groups.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2992769&req=5

Figure 1: Frequency distribution of the number of effect alleles in normal-weight, overweight, and obese groups.
Mentions: Figure 1 shows the frequency distribution of the number of effect alleles of the six SNPs in normal-weight, overweight, and obese groups. The associations of the number of effect alleles with overweight and obesity are shown in supplementary Table 7. Most subjects of each group carry four to six effect alleles. In the obese group, compared with subjects that carry three or fewer effect alleles, the risk of obesity of the subjects that carry four to six and greater than seven effect alleles was 1.54 (one-sided 95% CI >1.31; one-sided P = 5.9 × 10−6) and 2.50 (one-sided 95% CI >1.97; one-sided P = 1.3 × 10−10), respectively. There were significant associations of the number of effect alleles with anthropometric indexes (except birth weight) including BMI, waist circumference, WHtR, and FMP (supplementary Table 8).

Bottom Line: Childhood obesity strongly predisposes to some adult diseases.A total of 3,503 children participated in the study, including 1,229 obese, 655 overweight, and 1,619 normal-weight children (diagnosed by the Chinese age- and sex-specific BMI cutoffs).The SNPs rs17782313 and rs10938397 were also significantly associated with waist circumference, waist-to-height ratio, and fat mass percentage.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.

ABSTRACT

Objective: Childhood obesity strongly predisposes to some adult diseases. Recently, genome-wide association (GWA) studies in Caucasians identified multiple single nucleotide polymorphisms (SNPs) associated with BMI and obesity. The associations of those SNPs with BMI and obesity among other ethnicities are not fully described, especially in children. Among those previously identified SNPs, we selected six (rs7138803, rs1805081, rs6499640, rs17782313, rs6265, and rs10938397, in or near obesity-related genes FAIM2, NPC1, FTO, MC4R, BDNF, and GNPDA2, respectively) because of the relatively high minor allele frequencies in Chinese individuals and tested the associations of the SNPs with BMI and obesity in Chinese children.

Research design and methods: We investigated the associations of these SNPs with BMI and obesity in school-aged children. A total of 3,503 children participated in the study, including 1,229 obese, 655 overweight, and 1,619 normal-weight children (diagnosed by the Chinese age- and sex-specific BMI cutoffs).

Results: After age and sex adjustment and correction for multiple testing, the SNPs rs17782313, rs6265, and rs10938397 were associated with BMI (P = 1.0 × 10⁻⁵, 0.038, and 0.00093, respectively) and also obesity (P = 5.0 × 10⁻⁶, 0.043, and 0.00085, respectively) in the Chinese children. The SNPs rs17782313 and rs10938397 were also significantly associated with waist circumference, waist-to-height ratio, and fat mass percentage.

Conclusions: Results of this study support obesity-related genes in adults as important genes for BMI variation in children and suggest that some SNPs identified by GWA studies in Caucasians also confer risk for obesity in Chinese children.

Show MeSH
Related in: MedlinePlus