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Quality assurance in the HIV/AIDS laboratory network of China.

Jiang Y, Qiu M, Zhang G, Xing W, Xiao Y, Pan P, Yao J, Ou CY, Su X - Int J Epidemiol (2010)

Bottom Line: The NARL and provincial laboratories provide quality assurance through technical, bio-safety and managerial training; periodic proficiency testing; on-site supervisory inspections; and commercial serologic kit evaluations.China has made significant progress in establishing a well-coordinated HIV laboratory network and QA systems.However, the coverage and intensity of HIV testing and quality assurance programmes need to be strengthened so as to ensure that more infected persons are diagnosed and that they receive timely prevention and treatment services.

View Article: PubMed Central - PubMed

Affiliation: Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China. jiangyan03@263.net

ABSTRACT

Background: In 2009, there were 8273 local screening laboratories, 254 confirmatory laboratories, 35 provincial confirmatory central laboratories and 1 National AIDS Reference Laboratory (NARL) in China. These laboratories were located in Center for Disease Control and Prevention (CDC) facilities, hospitals, blood donation clinics, maternal and child health (MCH) hospitals and border health quarantine health-care facilities.

Methods: The NARL and provincial laboratories provide quality assurance through technical, bio-safety and managerial training; periodic proficiency testing; on-site supervisory inspections; and commercial serologic kit evaluations.

Results: From 2002 to 2009, more than 220 million HIV antibody tests were performed at screening laboratories, and all reactive and indeterminate samples were confirmed at confirmatory laboratories. The use of highly technically complex tests, including CD4 cell enumeration, viral load, dried blood spot (DBS)-based early infant diagnosis (EID), drug resistance (DR) genotyping, HIV-1 subtyping and incidence assays, have increased in recent years and their performance quality is closely monitored.

Conclusion: China has made significant progress in establishing a well-coordinated HIV laboratory network and QA systems. However, the coverage and intensity of HIV testing and quality assurance programmes need to be strengthened so as to ensure that more infected persons are diagnosed and that they receive timely prevention and treatment services.

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Related in: MedlinePlus

The yearly increase of screening (A) and confirmatory and confirmatory central laboratories (B) and the respective tests performed in China between 1992 and 2009. Diamonds: numbers of laboratories; squares: numbers of tests performed
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Figure 1: The yearly increase of screening (A) and confirmatory and confirmatory central laboratories (B) and the respective tests performed in China between 1992 and 2009. Diamonds: numbers of laboratories; squares: numbers of tests performed

Mentions: The second stage of laboratory development occurred from 1989 to 2002. Initially, the role of the national reference laboratory was played by the Institute of Virology at the Chinese Academy of Preventive Medicine. In 1998, the National AIDS Reference Laboratory (NARL) was established in the National Center for AIDS Prevention and Control of Chinese Center for Disease Control and Prevention (China CDC). By 2002, 44 confirmatory laboratories and 1870 screening laboratories were operational, which conducted more than 22 000 confirmatory and 12.3 million screening tests (Figure 1).Figure 1


Quality assurance in the HIV/AIDS laboratory network of China.

Jiang Y, Qiu M, Zhang G, Xing W, Xiao Y, Pan P, Yao J, Ou CY, Su X - Int J Epidemiol (2010)

The yearly increase of screening (A) and confirmatory and confirmatory central laboratories (B) and the respective tests performed in China between 1992 and 2009. Diamonds: numbers of laboratories; squares: numbers of tests performed
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2992624&req=5

Figure 1: The yearly increase of screening (A) and confirmatory and confirmatory central laboratories (B) and the respective tests performed in China between 1992 and 2009. Diamonds: numbers of laboratories; squares: numbers of tests performed
Mentions: The second stage of laboratory development occurred from 1989 to 2002. Initially, the role of the national reference laboratory was played by the Institute of Virology at the Chinese Academy of Preventive Medicine. In 1998, the National AIDS Reference Laboratory (NARL) was established in the National Center for AIDS Prevention and Control of Chinese Center for Disease Control and Prevention (China CDC). By 2002, 44 confirmatory laboratories and 1870 screening laboratories were operational, which conducted more than 22 000 confirmatory and 12.3 million screening tests (Figure 1).Figure 1

Bottom Line: The NARL and provincial laboratories provide quality assurance through technical, bio-safety and managerial training; periodic proficiency testing; on-site supervisory inspections; and commercial serologic kit evaluations.China has made significant progress in establishing a well-coordinated HIV laboratory network and QA systems.However, the coverage and intensity of HIV testing and quality assurance programmes need to be strengthened so as to ensure that more infected persons are diagnosed and that they receive timely prevention and treatment services.

View Article: PubMed Central - PubMed

Affiliation: Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China. jiangyan03@263.net

ABSTRACT

Background: In 2009, there were 8273 local screening laboratories, 254 confirmatory laboratories, 35 provincial confirmatory central laboratories and 1 National AIDS Reference Laboratory (NARL) in China. These laboratories were located in Center for Disease Control and Prevention (CDC) facilities, hospitals, blood donation clinics, maternal and child health (MCH) hospitals and border health quarantine health-care facilities.

Methods: The NARL and provincial laboratories provide quality assurance through technical, bio-safety and managerial training; periodic proficiency testing; on-site supervisory inspections; and commercial serologic kit evaluations.

Results: From 2002 to 2009, more than 220 million HIV antibody tests were performed at screening laboratories, and all reactive and indeterminate samples were confirmed at confirmatory laboratories. The use of highly technically complex tests, including CD4 cell enumeration, viral load, dried blood spot (DBS)-based early infant diagnosis (EID), drug resistance (DR) genotyping, HIV-1 subtyping and incidence assays, have increased in recent years and their performance quality is closely monitored.

Conclusion: China has made significant progress in establishing a well-coordinated HIV laboratory network and QA systems. However, the coverage and intensity of HIV testing and quality assurance programmes need to be strengthened so as to ensure that more infected persons are diagnosed and that they receive timely prevention and treatment services.

Show MeSH
Related in: MedlinePlus